JCPT  Vol.4 No.3 , July 2014
Synthesis and X-Ray Structure of New Anticancer Nucleosides Based on 1-((2-Hydroxyethoxy)methyl)-5-(phenylthio)-1H-1,2,4-triazole-3-carboxamide
Abstract: A pair of new anticancer nucleosides based on 1,2,4-triazole nucleosides and 1-((2-hydroxyethoxy) methyl)-5-(phenylthio)-1H-1,2,4-triazole-3-carboxamide have been synthesized, and have given the corresponding products in excellent yields. Its structures and conformations were confirmed by single crystal X-ray diffraction.
Cite this paper: Lei, Y. , Zhang, D. , Liu, Y. , Tian, G. and Ge, H. (2014) Synthesis and X-Ray Structure of New Anticancer Nucleosides Based on 1-((2-Hydroxyethoxy)methyl)-5-(phenylthio)-1H-1,2,4-triazole-3-carboxamide. Journal of Crystallization Process and Technology, 4, 135-139. doi: 10.4236/jcpt.2014.43017.

[1]   Claire, S. (2001) Nucleoside Mimetics: Their Chemistry and Biological Properties (Advanced Chemistry Texts). Gordon and Beach Science, UK.

[2]   Herdewijn, P., Ed. (2008) Modified Nucleosides in Biochemistry, Biotechnology and Medicine. Wiley-VCH, Weinheim.

[3]   Xia, Y., Liu, Y., Wan, J.Q., Wang, M.H., Rocchi, P., Qu, F.Q., Iovanna, J.L. and Peng, L. (2009) Novel Triazole Ribonucleoside Down-Regulates Heat Shock Protein 27 and Induces Potent Anticancer Activity on Drug-Resistant Pancreatic Cancer. Journal of Medicinal Chemistry, 52, 6083-6096.

[4]   Wan, J.Q., Xia, Y., Liu, Y., Wang, M.H., Rocchi, P., Yao, J.H., Qu, F.Q., Neyts, J., Iovanna, J.L. and Peng, L. (2009) Discovery of Novel Arylethynyltriazole Ribonucleosides with Selective and Effective Antiviral and Antiproliferative Activity. Journal of Medicinal Chemistry, 52, 1144-1155.

[5]   Rivera, F., López-Tarruella, S., Vega-Villegas, M.E. and Salcedo, M. (2009) Treatment of Advanced Pancreatic Cancer: From Gemcitabine Single Agent to Combinations and Targeted Therapy. Cancer Treatment Review, 35, 335-339.

[6]   Pierantoni, C., Pagliacci, A., Scartozzi, M., Berardi, R., Bianconi, M. and Cascinu, S. (2008) Pancreatic Cancer: Progress in Cancer Therapy. Critical Reviews in Oncology/Hematology, 67, 27-38.

[7]   Wong, H.H. and Lemoine, N.R. (2009) Pancreatic Cancer: Molecular Pathogenesis and New Therapeutic Targets. Nature Reviews Gastroenterology and Hepatology, 6, 412-422.

[8]   Liu, Y., Xia, Y., Li, W., Maggiani, A., Leyssen, P., Qu, F.Q., Neyts, J. and Peng, L. (2010) S-Aryltriazole Acyclonuc-leosides: Synthesis and Biological Evaluation against Hepatitis C Virus. Bioorganic & Medicinal Chemistry Letters, 20, 3610-3613.

[9]   Narik, S.R., Witkowski, J.T. and Robins, R.K. (1974) Synthesis of Nucleosides of 5-Substituted-1,2,4-triazole-3-carboxamides. Journal of Heterocyclic Chemistry, 11, 57-61.