OJMC  Vol.4 No.2 , June 2014
Experience of Using the Recombinant Human Superoxide Dismutase Drug in Neurological and Ophthalmological Practice
Abstract: Recsod? has been used for treating epilepsy and ophthalmological disease. Oxidative stress has been demonstrated to be a pathogenic chain of these diseases. Parameters of pro- and antioxidant systems were studied in all the patients treated. Recsod? drug was shown to produce positive effect in all the patients. Improvement of patients’ clinical condition correlated with an increase in antioxidant activities. Antioxidants, in particular, the recombinant human SOD drug, proved to be effective in treatment of some neurological and ophthalmological diseases.
Cite this paper: Dubinina, E. , Churilova, I. , Lipatova, L. and Zhuravleva, L. (2014) Experience of Using the Recombinant Human Superoxide Dismutase Drug in Neurological and Ophthalmological Practice. Open Journal of Medicinal Chemistry, 4, 70-78. doi: 10.4236/ojmc.2014.42005.

[1]   Gutteridge, J.M.C. and Halliwell, B. (2000) Free Radicals and Antioxidants in the Year 2000. Annals of the New York Academy of Sciences, 899, 136-147.

[2]   Menszikova, E.B., Lankin, V.Z., Zenkov, N.K., Bondar, I.A. and Krugovich, N.F. (2006) Oxidative Stress. Prooxidants and Antioxidants.

[3]   Halliwell, B. (1992) Reactive Oxygen Species and the Central Nervous System. In: Packer, L., Philipko, L. and Christen, Y., Eds., Free Radical in the Brain. Aging, Neurological and Mental Disorders. Springer-Verlag, Berlin, 21-40.

[4]   Dubinina, E.E. (2006) Oxygen Metabolism Products in Cell’s Functional Activity (Life and Death, Creation and Destruction).

[5]   Goss-Sampson, M., Vivian, A.J. and Kelly, T.J. (1995) Freeradicals, Inflammationand Eye Diseases. In: Blake, D., Ed., Immunopharmacology of Free Radical Speacies, Academic Press Limited, London, 127-143.

[6]   Mulroy, L., McGarvey, D.J., Truscott, T.G., Boulton, M. and Davies, S. (1998) Age-Related Macular Degeneration: Understanding the Roles of Lipofuscin, Macular Carotenoid Pigments and Reactive Oxygen Species. Investigative Ophthalmology & Visual Science, 39, S129.

[7]   Chan, D. (1998) Cigarette Smoking and Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science (United States), 75, 476-484.

[8]   Halliwell, B. (1992) Reactive Oxygen Species and the Central Nervous System. Journal of Neurochemistry, 59, 1609- 1623.

[9]   Boldirev, A.A. (2003) The Role of Active Forms of Oxygen in the Life of the Neuron. The Success of Physiol. Sciences, 34, 21-34.

[10]   Dubinina, E.E. and Pustigina, A.V. (2007) Free Radicals Process during Aging, Neurodegenerative Diseases and Other Pathological Conditions. Biomedicalchemistry, 53, 351-372.

[11]   Youdim, M.B.H. (1988) Brainiron. Neurochemical and Behavioural Aspects. Taylor and Francis, New York, 148 p.

[12]   Levadnaya, O.V., Dontchenko, G.V., Valutsina, V.M., et al. (1998) The Ratio between Values of Activity of the Antioxidant System in Various Tissues of Intact Animals. Ukrainian Biochemical Journal, 70, 53-58.

[13]   Strain, J.J. and Mulholland, C.W. (1992) Vitamin C and Vitamin E—Synergistic Interactions in Vivo. In: Ement, I. and Chance, B., Eds., Free Radical and Aging, Birkhauser, Verlag, Basel, 419-422.

[14]   Barry, S. Winkler, M.E., Boulton, J.D., Gottsch, P.S. and Snodderly, D.M. (1999) Oxidative Damageand Age-Related Macular Degeneration. Molecular Vision, 5, 32-45.

[15]   Beatty, S., Koh, H., Phil, M., Henson, D. and Boulton, M. (2000) The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration. Survey of Ophthalmology, 45, 115-134.

[16]   Aguiar, C.C., Almeida, A.B., Araújo, P.V., de Abreu, R.N., Chaves, E.M., do Vale, O.C., Macêdo, D.S., Woods, D.J., Fonteles, M.M. and Vasconcelos, S.M. (2012) Oxidative Stress and Epilepsy: Literature Review. Oxidative Medicine and Cellular Longevity, 2012, 7952-7959.

[17]   Freitas, R. (2009) Investigation of Oxidative Stress Involvement in Hippocampus in Epilepsy Model Induced by Pilocarpine. Neuroscience Letters, 462, 225-229.

[18]   Rumiàa, J., Marmolb, F., Sanchezb, J., Giménez-Crouseillesc, J., Carrenod, M., Bargallód, N., Bogetd, T., Pintord, L., Setoaind, X., Donaired, A., Saeze, G.T., Ribaltaf, T., Ferrera, E. and Puig-Parelladaba, P. (2013) Oxidative Stress Markers in the Neocortex of Drug-Resistant Epilepsy Patient Submitted to Epilepsy Surgery. Epilepsy Research, 107, 75- 81.

[19]   Chang, S.J. and Yu, B.C. (2010) Mitochondrial Matters of the Brain: Mitochondrial Dysfunction and Oxidative Status in Epilepsy. Journal of Bioenergetics and Biomembranes, 42, 457-459.

[20]   Fasmon, C.S., Cole, P.J., Williams, A.I. and Hastings, M. (1980) The Measurement of Opsonic and Phagocytic Function by Luminol-Depends Chemiluminescence. Immunology, 41, 67-74.

[21]   Gavrilov, V.B., Gavrilov, A.R. and Mazhul, L.M. (1987) Analysis of Methods of Determining Products of Lipid Peroxidation in Serum Test with Thiobarbituric Acid. The Issues of Medical Chemistry, 33, 118-122.

[22]   Kum-Tatt, L. and It-Koon, T. (1974) А New Colorimrtric Method for the Determination of Glutation in Erythrocytes. Clinica Chimica Acta, 53, 153-161.

[23]   Ellman, G.L. (1959) Tissue Sulfhydryl Groups. Archives of Biochemistry and Biophysics, 82, 70-71.

[24]   Kostyuk, V.A., Potapovitch, A.I. and Kovaleva, Z.V. (1990) Simple and Sensitive Method for Determining the Activity of Superoxide Dismutase, Based on the Oxidation Reaction of Quercetin. The Issues of Medical Chemistry, 36, 88-91.

[25]   Korolyuk, M.A., Ivanova, L.I., Mayorova, I.G. and Tokareva, V.E. (1988) Method for Determining the Activity of Catalase. LBA. Thematter, 1, 16-19.

[26]   Dubinina, E.E., Burmistrov, S.O., Khodov, D.A. and Porotov, I.E. (1995) Oxidative Modification of Proteins in Human Serum. Methods of Its Determination. The Issues of Medical Chemistry, 41, 24-26.

[27]   Prashar, S., Pandav, S.S., Gupta, A. and Nath, R. (1993) Antioxidant Enzymes in RBCs Biological Index of Age Related Macular Degeneration. Acta Ophthalmologica (Copenh), 71, 214-218.

[28]   Cohen, S.M., Olin, K.L., Feuer, W.J., Hjelmeland, L., Keen, C.L. and Morse, L.S. (1994) Low Glutation Reductase and Peroxidase Activity in Age-Related Macular Degeneration. British Journal of Ophthalmology, 78, 791-774.

[29]   Delcourt, C., Cristol, J.P., Tessier, F., Léger, C.L., Descomps, B. and Papoz, L. (1999) Age-Related Macular Degeneration and Antioxidant Status in the POLA Study. Archives of Ophthalmology, 117, 1384-1390.

[30]   Mayansky, A.N. and Pikuza, O.N. (1993) Clinical Aspects of Phagocytosis. Magarif, Kazan, 76-78.

[31]   Alekseev, V.N. and Usachev, V.V. (2003) Study of the Efficacy of the Drug Rexod in Patients with Primary Open-Angle Glaucoma. Saturday Papers Dedicated to the 90th Anniversary of Department, State Medical Academy of Them, Mechnikov, Glaucoma and Other Eye Diseases, SPb, 97-106.

[32]   Stefanov, A.V., Derimedved, L.V., Churilova, I.V., Drogovoz, S.M., Kutsenko, T.A. and Shchekina, E.G. (2004) Clinical and Experimental Substantiation of Application of Superoxide Dismutase in Medicine. Publishing House of Pau, Golden, p. 288.

[33]   Dubinina, E.E., Sofronova, L.N., Litvinenko, L.A. and Muschkatina, O.F. (1991) Diagnostic Value of Determines the State of the Antioxidant System in Retinopathy of Prematurity. Issues of Protection of Motherhood and Childhood, 36, 30-34.

[34]   Ben-Menachem, E., Kyllerman, M. and Marklund, S. (2000) Superoxide Dismutase and Glutathione Peroxidase Function in Progressive Myoclonus Epilepsies. Epilepsy Research, 40, 33-39.

[35]   Chen, D., Lu, Y., Yu, W., Luo, J., Xiao, Z., Xiao, F. and Wang, X. (2012) Clinical Value of Decreased Superoxide Dismutase 1 in Patients with Epilepsy. Seizure: European Journal of Epilepsy, 21, 508-511.