[1] Lim, S.S., et al. (2012) A Comparative Risk Assessment of Burden of Disease and Injury Attributable to 67 Risk Factors and Risk Factor Clusters in 21 Regions, 1990-2010: A Systematic Analysis for the Global Burden of Disease Study 2010. Lancet, 380, 2224-2260.
http://dx.doi.org/10.1016/S0140-6736(12)61766-8
[2] World Health Organization (2009) WHO/UNICEF Estimates of National Immunization Coverage. World Health Organization, Geneva.
http://www.who.int/immunization_monitoring/routine/immunization_coverage/en/index.html
[3] Kannel, W.B. (1996) Blood Pressure as a Cardiovascular Risk Factor: Prevention and Treatment. The Journal of the American Medical Association, 273, 1571-1576.
http://dx.doi.org/10.1001/jama.1996.03530440051036
[4] Dórea, E.L. and Lotufo, P.A. (2004) Epidemiologia da Hipertensao Arterial Sistêmica. Revista da Sociedade Brasileira de Hipertensao, 7, 86-93.
[5] Santos, J.C., Faria Jr., M. and Restini, C.B.A. (2012) Potenciais interacoes medicamentosas identificadas em prescricoes a pacientes hipertensos. Rev Bras Clin Med., 10, 1-10.
[6] Hashmi, S.K., Afridi, M.B., Abbas, K., Sajwani, R.A., Saleheen, D., et al. (2007) Factors Associated with Adherence to Anti-Hypertensive Treatment in Pakistan. PLoS ONE, 2, 1-8.
http://dx.doi.org/10.1371/journal.pone.0000280
[7] American College of Preventive Medicine (2011) Medication Adherence Time Tool: Improving Health Outcomes.
http://www.acpm.org/?MedAdherTT_ClinRef#
[8] Sarquis, L.M.M., et al. (1998) A Adesao ao Tratamento na Hipertensao Arterial: Analise da Producao Científica. Revista da Escola de Enfermagem da USP, 32, 353-355.
[9] Clark, L.T., et al. (1991) Improving Compliance and Increasing Control of Hypertension: Needs of Special Hypertensive Populations. American Heart Journal, 121, 664-669.
http://dx.doi.org/10.1016/0002-8703(91)90443-L
[10] Jin, J., Sklar, G.E., Oh, V.M.S. and Li, S.C. (2008) Factors Affecting Therapeutic Compliance: A Review from the Patient’s Perspective. Therapeutics and Clinical Risk Management, 4, 269-286.
[11] Furchgott, R. and Zawadzki, J.V.B. (1980) The Obligatory Role of Endothelial Cells in The Relaxation of Arterial Smooth Muscle by Acetylcholine. Nature, 288, 373-376.
http://dx.doi.org/10.1038/288373a0
[12] Verma, S. and Anderson, T.J. (2002) Fundamentals of Endothelial Function for the Clinical Cardiologist. Circulation, 105, 546-549.
http://dx.doi.org/10.1161/hc0502.104540
[13] Moncada, S. and Higgs, A. (2012) The L-Arginine-Nitric Oxide Pathway. The New England Journal of Medicine, 1993, 329.
[14] Dzau, V.J. (1989) Significance of Endothelial Derived Vasoactive Substances. Journal of Vascular Medicine and Biology, I, 43-55.
[15] Endemann, D. and Schiffrin, E. (2004) Endothelial Dysfunction. Frontiers in Nephrology, 15, 1983-1992.
[16] Sotomayor, M.A., Perez-Guerrero, C., Herrera, M.D. and Marhuenda, E. (1999) Effects of Chronic Treatment with Simvastatin on Endothelial Dysfunction in Spontaneously Hypertensive Rats. Journal of Hypertension, 17, 769-776.
http://dx.doi.org/10.1097/00004872-199917060-00008
[17] Calver, A., Collier, J., Moncada, S. and Vallance, P. (1992) Effect of Local Intra-Arterial NG-Monomethil-L-Arginine in Patients with Hypertension: The Nitric Oxide Dilator Mechanism Appears Abnormal. Journal of Hypertension, 10, 1025-1031.
http://dx.doi.org/10.1097/00004872-199209000-00017
[18] Schiffrin, E.L. (2001) A Critical Review of the Role of Endothelial Factors in the Pathogenesis of Hypertension. Journal of Cardiovascular Pharmacology, 38, S3-S6.
http://dx.doi.org/10.1097/00005344-200111002-00002
[19] Koppenol, W.H., Moreno, J.J., Pryor, W., Ischiropoulos, H. and Beckman, J.S. (1992) Peroxynitrite, a Cloaked Oxidant Formed by Nitric Oxide and Superoxide. Chemical Research in Toxicology, 5, 834-842.
http://dx.doi.org/10.1021/tx00030a017
[20] Milstien, S. and Katusic, Z. (1999) Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function. Biochemical and Biophysical Research Communications, 263, 681-684.
http://dx.doi.org/10.1006/bbrc.1999.1422
[21] Landmesser, U. and Harrison, D.G. (2001) Oxidative Stress and Vascular Damage in Hypertension. Coronary Artery Disease, 12, 455-461.
http://dx.doi.org/10.1097/00019501-200109000-00004
[22] Grossman, E. (2008) Does Increased Oxidative Stress Cause Hypertension? Diabetes Care, 31, S185-S189.
http://dx.doi.org/10.2337/dc08-s246
[23] Han, X.Z., Shen, T. and Lou, H.X. (2007) Dietary Polyphenols and Their Biological Significance. International Journal of Molecular Sciences, 8, 950-988.
http://dx.doi.org/10.3390/i8090950
[24] Wang, S.J., Wang, X.X., Yan, J., Xie, X.D., Fan, F.H., Zhou, X.H., Han, L. and Chen, J.Z. (2007) Resveratrol Inhibits Proliferation of Cultured Rat Cardiac Fibroblasts: Correlated With NO-cGMP Signaling Pathway. European Journal of Pharmacology, 567, 26-35.
http://dx.doi.org/10.1016/j.ejphar.2007.04.023
[25] Goldblatt, H., Lynch, J., Hamzal, R. and Summerville, W.W. (1934) Studies on Experimental Hypertension, I: The Production of Persistent Elevation of Systolic Blood Pressure by Means of Renal Ischemia. Journal of Experimental Medicine, 59, 347-379.
http://dx.doi.org/10.1084/jem.59.3.347
[26] Mok, J., Kong, M. and Hutchinson, J. (1985) Cardiovascular Effects of Central and Peripheral Administration of Dopamine in Hypertensive and Normotensive Rats. Indian Journal of Pharmacology, 17, 192-196.
[27] Boulanger, C. and Lüscher, T.F. (1990) Release of Endothelin from the Porcine Aorta: Inhibition by Endothelium-Derived Nitric Oxide. Journal of Clinical Investigation, 85, 587-590.
http://dx.doi.org/10.1172/JCI114477
[28] Fazan, J.R.R., Silva, V.J.D. and Salgado, H.C. (2001) Modelos De Hipertensao Arterial. Revista Brasileira De Hipertensao, 8, 19-29.
[29] Simone, G., Devereux, R.B., Chinali, M., Roman, M.J., Best, L.G., Welty, T.K., Lee, E.T., Howard, B.V. for the Strong Heart Study Investigators (2006) Risk Factors for Arterial Hypertension in Adults with Initial Optimal Blood Pressure: The Strong Heart Study. Hypertension, 47, 162-167.
http://dx.doi.org/10.1161/01.HYP.0000199103.40105.b5
[30] Usui, M., Egashira, K., Kitamoto, S., Koyanagi, M., Katoh, M., Kataoka, C., Shimokawa, H. and Takeshita, A. (1999) Pathogenic Role of Oxidative Stress in Vascular Angiotensin-Converting Enzyme Activation in Long-Term Blockade of Nitric Oxide Synthesis in Rats. Hypertension, 34, 546-551.
http://dx.doi.org/10.1161/01.HYP.34.4.546
[31] Callera, G.E., Varanda, W.A. and Bendhack, L.M. (2000) Impaired Relaxation to Acetylcholine in 2K-1C Hypertensive Rat Aortas Involves Changes in Membrane Hyperpolarization Instead of an Abnormal Contribution of Endothelial Factors. General Pharmacology, 34, 379-389.
http://dx.doi.org/10.1016/S0306-3623(01)00075-1
[32] Callera, G.E., Varanda, W.A. and Bendhack, L.M. (2001) Ca2+ Influx Is Increased in 2-Kidney, 1-Clip Hypertensive Rat Aorta. Hypertension, 38, 592-596.
http://dx.doi.org/10.1161/hy09t1.096248
[33] Lunardi, C.N., da Silva, R.S. and Bendhack, L.M. (2009) New Nitric Oxide Donors Based on Ruthenium Complexes. Brazilian Journal of Medical and Biological Research, 42, 87-93.
http://dx.doi.org/10.1590/S0100-879X2009000100013
[34] Callera, G.E., Varanda, W.A. and Bendhack, L.M. (2000) Impaired Relaxation to Acetylcholine in 2K-1C Hypertensive Rat Aortas Involves Changes in Membrane Hyperpolarization Instead of an Abnormal Contribution of Endothelial Factors. General Pharmacology, 34, 379-389.
http://dx.doi.org/10.1016/S0306-3623(01)00075-1
[35] Mantelli, L., Amerini, S. and Ledda, F. (1995) Roles of Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor in Vasorelaxant Effect of Acetylcholine as Influenced by Aging and Hypertension. Journal of Cardiovascular Pharmacology, 25, 595-602.
http://dx.doi.org/10.1097/00005344-199504000-00013
[36] Heitzer, T., Wenzel, U., Hink, U., Krollner, D., Skatchkov, M., Stahl, R.A.K., Macharzina, R., Brasen, J.H., Meinertz, T. and Münze, T. (1999) Increased NAD(P)H Oxidase-Mediated Superoxide Production in Renovascular Hypertension: Evidence for an Involvement of Protein Kinase C. Kidney International, 55, 252-260.
http://dx.doi.org/10.1046/j.1523-1755.1999.00229.x
[37] Okamura, T., Miyazaki, M., Inagami, T. and Toda, N. (1986) Vascular Renin-Angiotensin System in Two Kidney, One Clip Hypertensive Rats. Hypertension, 8, 560-565.
http://dx.doi.org/10.1161/01.HYP.8.7.560
[38] Martinez-Maldonado, M. (1991) Pathophysiology of Renovascular Hypertension. Hypertension, 17, 707-719.
http://dx.doi.org/10.1161/01.HYP.17.5.707
[39] Guan, S., Fox, J., Mitchell, K.D. and Navar, L.G. (1992) Angiotensin and Angiotensin Converting Enzyme Tissue Levels in Two-Kidney, One Clip Hypertensive Rats. Hypertension, 20, 763-767.
http://dx.doi.org/10.1161/01.HYP.20.6.763
[40] Kojda, G. and Harrison, D. (1999) Interactions between NO and Reactive Oxygen Species: Pathophysiological Importance in Atherosclerosis, Hypertension, Diabetes and Heart Failure. Cardiovascular Research, 43, 562-571.
http://dx.doi.org/10.1016/S0008-6363(99)00169-8
[41] Rubany, G.M. and Vanhoutte, P.M. (1986) Superoxide Anions and Hyperoxia Inactivate Endothelium-Derived Relaxing Factor. American Journal of Physiology, 250, H822-H827.
[42] Dell'agli, M., Busciala, A. and Bosisio, E. (2004) Vascular Effects of Wine Polyphenols. Cardiovascular Research, 63, 593-602.
[43] de Oliveira, J.C., Antonietto, C.R.K., Scalabrini, A.C., Marinho, T.S., Pernomian, L. and Corrêa, J.W.N. (2012) Antioxidant Protective Effects of the Resveratrol on the Cardiac and Vascular Tissues from Renal Hypertensive Rats. Open Journal of Medicinal Chemistry, 2, 61-71.
http://dx.doi.org/10.4236/ojmc.2012.23008
[44] Sobey, C.G. (2001) Potassium Channel Function in Vascular Disease. Arteriosclerosis, Thrombosis and Vascular Bio- logy, 21, 28-38.
http://dx.doi.org/10.1161/01.ATV.21.1.28
[45] Lima, M.S., de Souza Veras Silani, I., Toaldo, I.M., Corrêa, L.C., Telles Biasoto, A.C., Pereira, G.E., Bordignon-Luiz, M.T. and Ninow, J.L. (2014) Phenolic Compounds, Organic Acids and Antioxidant Activity of Grape Juices Produced from New Brazilian Varieties Planted in the Northeast Region of Brazil. Food Chemistry, 161, 94-103.
http://dx.doi.org/10.1016/j.foodchem.2014.03.109
[46] Dolinsky, V., Chakrabarti, S., Pereira, T.J., Oka, T., Levasseur, J., Beker, D., Zordoky, B.N., Morton, J.S., Nagendran, J., Lopaschuk, G.D., Davidge, S.T. and Dyck, J.R.B. (2013) Resveratrol Prevents Hypertension and Cardiac Hypertrophy in Hypertensive Rats and Mice. Biochimica et Biophysica Acta, 1832, 1723-1733.
http://dx.doi.org/10.1016/j.bbadis.2013.05.018