Osteoporosis has become one of the most prevalent bone diseases in developed
countries. As the world’s population ages, this complex skeletal disorder is predicted
to become an even more widespread and serious health condition, posing greater societal
economic burden. Current therapeutic agents are limited by clinically significant
side effects. In this report, we present a case that suggests intra-articular platelet-rich
plasma (PRP) injectate may improve bone mineral density (BMD). This observation
raises a question with exciting implications—can PRP serve as a viable and relatively
safe, targeted treatment option to improve bone density?
Cite this paper
Ahmed, M. and Panagos, A. (2014) Intra-Articular Autologous Platelet-Rich Plasma Hip Injection May Result in Osteogenesis Depicted as an Increase in Femoral Neck Bone Density. Open Journal of Regenerative Medicine
, 39-42. doi: 10.4236/ojrm.2014.32005
 Arora, N.S., et al. (2009) Platelet-Rich Plasma: A Literature Review. Implant Dentistry, 18, 303-310. http://dx.doi.org/10.1097/ID.0b013e31819e8ec6
 Marx, R.E. (2004) Platelet-Rich Plasma: Evidence to Support Its Use. Journal of Oral and Maxillofacial Surgery, 62:489-496. http://dx.doi.org/10.1016/j.joms.2003.12.003
 Liu, H., et al. (2011) The Balance between Adipogenesis and Osteogenesis in Bone Regeneration by Platelet-Rich Plasma for Age-Related Osteoporosis. Biomaterials, 32, 6773-6780. http://dx.doi.org/10.1016/j.biomaterials.2011.05.080
 Mitchner, N.A. and Harris, S.T. (2009) Current and Emerging Therapies for Osteoporosis. The Journal of Family Practice, 58, S45-S49.
 Marx, R.E., Carlson, E.R., Eichstaedt, R.M., et al. (1998) Platelet-Rich Plasma: Growth Factor Enhancement for Bone Grafts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 85, 638-646. http://dx.doi.org/10.1016/S1079-2104(98)90029-4
 Prentice, A. (2004) Diet, Nutrition and the Prevention of Osteoporosis. Public Health Nutrition, 7, 227-243.
 Ian R.R., et al. (2013) Effects of Vitamin D Supplements on Bone Mineral Density: A Systematic Review and Meta-Analysis. The Lancet, 383, 146-155.
 Duque, G. (2008) Bone and Fat Connection in Aging Bone. Current Opinion in Rheumatology, 20, 429-434. http://dx.doi.org/10.1097/BOR.0b013e3283025e9c
 Arvidson, K., et al. (2011) Bone Regeneration and Stem Cells. Journal of Cellular and Molecular Medicine, 15, 718-746. http://dx.doi.org/10.1111/j.1582-4934.2010.01224.x
 Lo, W.C., et al. (2009) Transplantation of Embryonic Fibroblasts Treated with Platelet-Rich Plasma Induces Osteogenesis in SAMP8 Mice Monitored by Molecular Imaging. Journal of Nuclear Medicine, 50, 765-773. http://dx.doi.org/10.2967/jnumed.108.057372