SS  Vol.5 No.6 , June 2014
Appendicular Neuroendocrine Tumors in Children
Abstract

Appendicular Neuroendocrine Tumors (ANETs) in pediatric age group are infrequent. Though children may present like symptoms of acute appendicitis, these tumors are incidentally picked up during routine histological examination of resected appendix. We report our experience with ANETs in children from a tertiary care hospital in Arabian Peninsula. During 6-year period, there were 700 appendectomies performed in children (≤14 years) and we collected only 3 cases of ANETs diagnosed from histological examination of resected appendix. Appendectomy alone has been sufficient in all cases and they are disease free at follow-up till 3 years after surgery. We have reviewed the clinical presentation, diagnosis and management of these cases. With no typical clinical picture, ANET is usually an incidental finding hence we propose that the review of the histology of resected appendix is mandatory to identify the prevalence of ANETs in pediatric population. For most patients, appendectomy is the appropriate treatment and the outcome is excellent after appendectomy.


Cite this paper
Mandhan, P. , Ismail, F. , Ali, M. and Soofi, M. (2014) Appendicular Neuroendocrine Tumors in Children. Surgical Science, 5, 246-251. doi: 10.4236/ss.2014.56043.
References

[1]   Emmanouil, H., Paraskevi, P., Vasiliki, S.-F., et al. (2010) Carcinoid Tumors of the Appendix in Children: Experience from a Tertiary Center in Northern Greece. Journal of Pediatric Gastroenterology & Nutrition, 51, 622-625. http://dx.doi.org/10.1097/MPG.0b013e3181e05358

[2]   Scott, A. and Upadhyay, V. (2011) Carcinoid Tumours of the Appendix in Children in Auckland, New Zealand: 1965-2008. The New Zealand Medical Journal, 124, 56-60.

[3]   Allan, B., Davis, J., Perez, E., Lew, J. and Sola, J. (2013) Malignant Neuroendocrine Tumors: Incidence and Outcomes in Pediatric Patients. European Journal of Pediatric Surgery, 23, 394-399.
http://dx.doi.org/10.1055/s-0033-1333643

[4]   Schmittenbecher, P.P. (2001) Carcinoid Tumours of the Appendix in Children—Epidemiology, Clinical Aspects and Procedures. European Journal of Pediatric Surgery, 11, 428.
http://dx.doi.org/10.1055/s-2001-19732

[5]   Dall’Igna, P., Andrea, F., Claudia, L., et al. (2005) Carcinoid Tumor of the Appendix in Childhood: The Experience of Two Italian Institutions. Journal of Pediatric Gastroenterology & Nutrition, 40, 216-219. http://dx.doi.org/10.1097/00005176-200502000-00025

[6]   Volpe, A., Willert, J., Ihnken, K., et al. (2000) Metastatic Appendiceal Carcinoid Tumor in a Child. Medical and Pediatric Oncology, 34, 218-220.
http://dx.doi.org/10.1002/(SICI)1096-911X(200003)34:3<218::AID-MPO12>3.0.CO;2-9

[7]   Doede, T., Foss, H.D. and Waldschmidt, J. (2000) Carcinoid Tumors of the Appendix in Children—Epidemiology, Clinical Aspects and Procedure. European Journal of Pediatric Surgery, 10, 372-377. http://dx.doi.org/10.1055/s-2008-1072394

[8]   Pelizzo, G., La Riccia, A., Bouvier, R., et al. (2001) Carcinoid Tumors of the Appendix in Children. Pediatric Surgery International, 17, 399-402. http://dx.doi.org/10.1007/s003830000559

[9]   Prommegger, R., Obrist, P., Ensinger, C., et al. (2002) Retrospective Evaluation of Carcinoid Tumors of the Appendix in Children. World Journal of Surgery, 26, 1489-1492.
http://dx.doi.org/10.1007/s00268-002-6440-3

[10]   Spunt, S.L., Pratt, C.B., Rao, B.N., et al. (2000) Childhood Carcinoid Tumors: The St Jude Children’s Research Hospital Experience. Journal of Pediatric Surgery, 35, 1282-1286.
http://dx.doi.org/10.1053/jpsu.2000.9297

[11]   Kulkarni, K.P. and Sergi, C. (2013) Appendix Carcinoids in Childhood: Long-Term Experience at a Single Institution in Western Canada and Systematic Review on Topic. Pediatrics International, 55, 157-162. http://dx.doi.org/10.1111/ped.12047

[12]   Jonsson, T., Johannsson, J.H. and Hallgrimsson, J.G. (1989) Carcinoid Tumors of the Appendix in Children Younger than 16 Years. A Retrospective Clinical and Pathologic Study. Acta Chirurgica Scandinavica, 155, 113-116.

 
 
Top