Health  Vol.6 No.12 , June 2014
The Relationships between Cognitive Neuropsychological State, Oxidative Stress and Genotoxicity in Radiology Staff
ABSTRACT
Imbalance between the production and removal of reactive oxygen species (ROS) has been used for characterizing Oxidative stress. Extra amount of ROS are hazardous and can lead damages to the cells resulting in harsh diseases. For cancer, diabetes, psychological disorders and age-related disorders, latent of ROS in induction of alteration and DNA harm is a critical factor. Regarding these finding, the current research was planned to test the relationship between cognitive neuropsychological state and oxidative markers and genotoxicity in radiology staff. Total Number of 47 radiology staff, working in the radiology center of a referral University Hospital in Shiraz, were invited in the study. The participants were occupationally exposed to low-dose ionizing radiation (x-ray) for more than 2 years. Psychological disorder was analyzed by SCL-90-R. In the plasma, lipid peroxidation, DNA harm, catalase, superoxide dismutase, myeloperoxidase, and glutathione peroxidase activity were calculated. Associations between parameters were measured by using Pearson correlation coefficient and multivariate linear regression analyses. As a result, there was a positive considerable connection between catalase and paranoid ideation, Obsessive-Compulsive, Anxiety and total. Furthermore, the correlation between psychoticism, Interpersonal Sensitivity, Paranoid Ideation and DNA damage was positive. There were positive relationships between superoxide dismutase and psychomotor speed, initiative/energy, selective attention and verbal memory. So, there were significant relationships among interpersonal sensitivity, somatization, depression and gender. But, there were no major relationships among psychological distress, history workers and oxidative stress. In so many words, Oxidative stress and genotoxicity result in psychological disorders in radiology staff. So, radiology staff should have more attention, as they suffered from some psychological disorders.

Cite this paper
Dastjerdi, H. , Fazilati, M. , Malekirad, A. , Nazem, H. , Abdollahi, M. and Zerratpisheh, A. (2014) The Relationships between Cognitive Neuropsychological State, Oxidative Stress and Genotoxicity in Radiology Staff. Health, 6, 1376-1384. doi: 10.4236/health.2014.612169.
References
[1]   Malekirad, A.A., Ranjbar, A., Rahzani, K., Pilehvarian, A.A., Rezaie, A., Zamani, M.J., et al. (2005) Oxidative Stress in Radiology Staff. Environmental Toxicology and Pharmacology, 20, 215-218.
http://dx.doi.org/10.1016/j.etap.2005.01.005

[2]   Zeraatpishe, A., Oryan, S., Bagheri, M.H., Pilevarian, A.A., Malekirad, A.A., Baeeri, M., et al. (2011) Effects of Melissa officinalis L. on Oxidative Status and DNA Damage in Subjects Exposed to Long-Term Low-Dose Ionizing Radiation. Toxicology and Industrial Health, 27, 205-212.
http://dx.doi.org/10.1177/0748233710383889

[3]   Pal, R., Ahmed, T., Kumar, V., Suke, S.G., Ray, A. and Banerjee, B.D. (2009) Protective Effects of Different Antioxidants against Endosulfan-Induced Oxidative Stress and Immunotoxicity in Albino Rats. Indian Journal of Experimental Biology, 47, 723-729.

[4]   Fani, A., Malekirad, A.A., Allahnazem, H., Rahzani, K., Ranjbar, A., Vosoughghanbari, S., et al. (2008) On the Benefit of Cinnamomumzeylanicum for Radiology Unit Staff. Journal of Medical Sciences, 8, 384-389.
http://scialert.net/abstract/?doi=jms.2008.384.389

[5]   Jokanovic, M. and Kosanovic, M. (2010) Neurotoxic Effects in Patients Poisoned with Organophosphorus Pesticides. Environmental Toxicology and Pharmacology, 29, 195-201.
http://dx.doi.org/10.1016/j.etap.2010.01.006

[6]   Tsaluchidu, S., Cocchi, M., Tonello, L. and Puri, B.K. (2008) Fatty Acids and Oxidative Stress in Psychiatric Disorders. BMC Psychiatry, 8, S5.
http://dx.doi.org/10.1186/1471-244X-8-S1-S5

[7]   Shao, L., Young, L.T. and Wang, J.F. (2005) Chronic Treatment with Mood Stabilizers Lithium and Valproate Prevents Excitotoxicity by Inhibiting Oxidative Stress in Rat Cerebral Cortical Cells. Biological Psychiatry, 58, 879-884.
http://dx.doi.org/10.1016/j.biopsych.2005.04.052

[8]   Bilici, M., Efe, H., Köroglu, M.A., Uydu, H.A., Bekaroglu, M. and Deger, O. (2001) Antioxidative Enzyme Activities and Lipid Peroxidation in Major Depression: Alterations by Antidepressant Treatments. Journal of Affective Disorders, 64, 43-51.
http://dx.doi.org/10.1016/S0165-0327(00)00199-3

[9]   Sarandol, A., Sarandol, E., Eker, S.S., Erdinc, S., Vatansever, E. and Kirli, S. (2007) Major Depressive Disorder Is Accompanied with Oxidative Stress: Short-Term Antide-pressant Treatment Does Not Alter Oxidative-Antioxidative Systems. Human Psychopharmacology: Clinical and Experimental, 22, 67-73.

[10]   Andreazza, A.C., Frey, B.N., Erdtmann, B., Salvador, M., Rombaldi, F., Santin, A., et al. (2007) DNA Damage in Bipolar Disorder. Psychiatry Research, 153, 27-32.
http://dx.doi.org/10.1016/j.psychres.2006.03.025

[11]   Ersan, S., Bakir, S., Erdal Ersan, E. and Dogan, O. (2006) Examination of Free Radical Metabolism and Antioxidant Defence System Elements in Patients with Obsessive-Compulsive Disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30, 1039-1042.
http://dx.doi.org/10.1016/j.pnpbp.2006.03.034

[12]   Chakraborty, S., Singh, O.P., Dasgupta, A., Mandal, N. and Nath Das, H. (2009) Correlation between Lipid Peroxidation-Induced TBARS Level and Disease Severity in Obsessive-Compulsive Disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33, 363-366.
http://dx.doi.org/10.1016/j.pnpbp.2009.01.001

[13]   Ozdemir, E., Cetinkaya, S., Ersan, S., Kucukosman, S. and Ersan, E.E. (2009) Serum Selenium and Plasma Malon-Dialdehyde Levels and Antioxidant Enzyme Activities in Patients with Obsessive-Compulsive Disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33, 62-65.
http://dx.doi.org/10.1016/j.pnpbp.2008.10.004

[14]   Ratnakar, S., Banupriya, C., Doureradjou, P., Vive-kanandam, S., Srivastava, M.K. and Koner, B.C. (2008) Evaluation of Anxiety, Depression and Urinary Protein Excretion among the Family Caregivers of Advanced Cancer Patients. Biological Psychology, 79, 234-238.
http://dx.doi.org/10.1016/j.biopsycho.2008.06.001

[15]   Forlenza, M.J. and Miller, G.E. (2006) Increased Serum Levels of 8-Hydroxy-2-Deoxyguanosine in Clinical Depression. Psychosomatic Medicine, 68, 1-7.
http://dx.doi.org/10.1097/01.psy.0000195780.37277.2a

[16]   Sögüt, S., Zoroglu, S.S., Ozyurt, H., Yilmaz, H.R., Ozugurlu, F., Sivasli, E., Yetkin, Ö., Yanik, M., Tutkun, H., Savas, H.A., Tarakçioglu, M. and Akyol, Ö. (2003) Changes in Nitric Oxide Levels and Antioxidant Activities May Have a Role in the Pathophysiological Mechanisms Involved in Autism. Clinica Chimica Acta, 331, 111-117.
http://dx.doi.org/10.1016/S0009-8981(03)00119-0

[17]   Chauhan, A., Chauhan, V., Brown, W.T. and Cohen, I. (2004) Oxidative Stress in Autism: Increased Lipid Peroxidation and Reduced Serum Levels of Ceruloplasmin and Transferring—The Antioxidant Proteins. Life Sciences, 75, 2539-2549.
http://dx.doi.org/10.1016/j.lfs.2004.04.038

[18]   Markesbery, W.R. and Lovell, M.A. (2007) Damage to Lipids, Proteins, DNA, and RNA in Mild Cognitive Impairment. JAMA Neurology, 64, 954-956.
http://dx.doi.org/10.1001/archneur.64.7.954

[19]   Gil, P., Fariñas, F., Casado, A. and López-Fernández, E. (2002) Malondialdehyde: A Possible Marker of Ageing. Gerontology, 48, 209-214.
http://dx.doi.org/10.1159/000058352

[20]   Derogatis, L.R., Lipman, R.S. and Cavi, L. (1973) SCL-90: An Out-patient Psychiatric Rating Scale—Preliminary Report. Psychopharmacology Bulletin, 9, 13-28.

[21]   Bayrami, M., Hashemi, T., Malekirad, A.A., Ashayeri, H., Faraji, F. and Abdollahi, M. (2012) Electroencephalogram, Cognitive State, Psychological Disorders, Clinical Symptom, and Oxidative Stress in Horticulture Farmers Exposed to Organophosphate Pesticides. Toxicology and Industrial Health, 28, 90-96.
http://dx.doi.org/10.1177/0748233711407243

[22]   Malekirad, A.A., Mirabdollahi, M., Pilevarian, A.A., Nassajpour, A.R. and Abdollahi, M. (2013) Neurocognitive Impairment, Clinical and Biochemical Toxicity Biomarkers in Iron-Steel Workers. Toxicology and Industrial Health.

[23]   Zimmermann, P., Messner, C., Poser, U. and Sedelmeier, P. (1991) Ein Fragebogen erlebter Defizite der Aufmerksamkeit (FEDA) [A Questionnaire Measuring Self-Experienced Deficits of Attention]. PsychologischesInstitut der Universität Freiburg, Freiburg.

[24]   Moritz, S., Ferahli, S. and Naber, D. (2004) Memory and Attention Performance in Psychiatric Patients Lack of Correspondence between Clinician-Rated and Patient-Rated Functioning with Neuropsychological Test Results. Journal of the International Neuropsychological Society, 10, 623-633.
http://dx.doi.org/10.1017/S1355617704104153

[25]   Esterabeur, H. and Cheeseman, K. (1990) Determination of Aldehyids Lipid Peroxidation Products: Malondealdhyde and 4-Hydroxylnonenal. Methods in Enzymology, 186, 407-421.
http://dx.doi.org/10.1016/0076-6879(90)86134-H

[26]   Benzi, I.F. and Strain, S. (1999) Ferric Reducing Antioxidant Assay. Methods in Enzymology, 292, 15-27.

[27]   Hu, M.L. and Dillard, C.J. (1994) Plasma SH and GSH Measurement. Methods in Enzymology, 233, 385-387.

[28]   Ozcan, M.E., Gulec, M., Ozerol, E., Polat, R. and Akyol, O. (2004) Antioxidant Enzyme Activities and Oxidative Stress in Affective Disorders. International Clinical Psychopharmacology, 19, 89-95.
http://dx.doi.org/10.1097/00004850-200403000-00006

[29]   Marazziti, D., Baroni, S., Catena-Dell’Osso, M., Schiavi, E., Ceresoli, D., Conversano, C., Dell’Osso, L. and Picano, E. (2012) Cognitive, Psychological and Psychiatric Effects of Ionizing Radiation Exposure. Current Medicinal Chemistry, 19, 1864-1869.
http://dx.doi.org/10.2174/092986712800099776

[30]   Panagiotakos, G., Alshamy, G., Chan, B., Abrams, R., Greenberg, E., Saxena, A., Bradbury, M., Edgar, M., Gutin, P. and Tabar, V. (2007) Long-Term Impact of Radiation on the Stem Cell and Oligodendrocyte Precursors in the Brain. PLoS ONE, 2, Article ID: e588.
http://dx.doi.org/10.1371/journal.pone.0000588

[31]   Lowe, X.R., Bhattacharya, S., Marchetti, F. and Wyrobek, A.J. (2009) Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer’s Disease. Radiation Research, 171, 53-65.
http://dx.doi.org/10.1667/RR1389.1

[32]   Fike, J.R. (2011) Physiopathology of Radiation-Induced Neurotoxicity. Revue Neurologique (Paris), 167, 746-750.
http://dx.doi.org/10.1016/j.neurol.2011.07.005

[33]   Cwikel, J.G., Gidron, Y. and Quastel, M. (2010) Low-Dose Environmental Radiation, DNA Damage, and Cancer: The Possible Contribution of Psychological Factors. Psychology, Health & Medicine, 15, 1-16.
http://dx.doi.org/10.1080/13548500903431493

[34]   Moroz, B.B., DeshevoiIu, B., Voronina, T.A., Lyrshchikova, A.V. and Lebedev, V.G. (2007) Effect of Mexidol on Hemopoietic System in Conditions of an Emotional Stress after Exposure to Ionizing Radiation. Radiatsionnaia Biologiia, Radioecologiia, 47, 163-170.

[35]   Armstrong, C.L., Corn, B.W., Ruffer, J.E., Pruitt, A.A., Mollman, J.E. and Phillips, P.C. (2000) Radiotherapeutic Effects on Brain Function: Double Dissociation of Memory Systems. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 13, 101-111.

[36]   Chen, S.C., Lai, Y.H., Liao, C.T., Lin, C.C. and Chang, J.T. (2010) Changes of Symptoms and Depression in Oral Cavity Cancer Patients Receiving Radiation Therapy. Oral Oncology, 46, 509-513.
http://dx.doi.org/10.1016/j.oraloncology.2010.02.024

[37]   Yen, P.N., Yang, C.C., Chang, P.W., Hwang, J.S., Lee, H.C., Kuo, K.L. and Lin, I.F. (2011) Perception of Quality of Life of a Cohort Population Years after Relocation from Previous Low-Dose Radiation Exposure in Co-60 Contaminated Buildings in Taiwan. International Journal of Radiation Biology, 87, 453-460.
http://dx.doi.org/10.3109/09553002.2011.544372

 
 
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