JBM  Vol.2 No.4 , June 2014
Enzyme Kinetic Equations of Irreversible and Reversible Reactions in Metabolism

This paper compares the irreversible and reversible rate equations from several uni-uni kinetic mechanisms (Michaelis-Menten, Hill and Adair equations) and bi-bi mechanisms (single- and double- displacement equations). In reversible reactions, Haldane relationship is considered to be identical for all mechanisms considered and reversible equations can be also obtained from this rela- tionship. Some reversible reactions of the metabolism are also presented, with their equilibrium constant.

Cite this paper
Imperial, S. and Centelles, J. (2014) Enzyme Kinetic Equations of Irreversible and Reversible Reactions in Metabolism. Journal of Biosciences and Medicines, 2, 24-29. doi: 10.4236/jbm.2014.24005.
[1]   Alberty, R.A., Cornish-Bowden, A., Goldberg, R.N., Hammes, G.G., Tipton, K. and Westerhoff, H.V. (2011) Reccommendations for Terminology and Databases for Biochemical Thermodynamics. Biophysical Chemistry, 155, 89- 103. http://dx.doi.org/10.1016/j.bpc.2011.03.007

[2]   Hofmeyr, J.-H.S. and Cornish-Bowden, A. (1997) The Reversible Hill Equation: How to Incorporate Cooperative Enzymes into Metabolic Models. CABIOS, 13, 377-385.

[3]   King, E.L. and Altman, C. (1956) A Schematic Method of Deriving the Rate Laws for Enzyme-Catalyzed Reactions. The Journal of Physical Chemistry, 60, 1373-1378. http://biokin.com/king-altman/index.html http://dx.doi.org/10.1021/j150544a010

[4]   Barman, T.E. (1969) Enzyme Handbook. Springer-Verlag, Berlin. http://dx.doi.org/10.1007/978-3-642-86602-9