this report, we present a 22-year-old patient with soft tissue sarcoma of the
lower extremity that developed wound dehiscence after
surgery. Biopsy demonstrated negative margins for cancer. He was treated with
negative pressure wound therapy for 6 weeks and started to present increased
wound exudates, local pain and proliferating tissue that was positive for tumor
recurrence. Consequently he underwent lower extremity amputation with hip
disarticulation by the orthopedic team. Although we cannot determine with
certainty a full causative relationship, it seems prudent to advise cautious
use of negative pressure wound therapy in oncologic related wound beds.
Cite this paper
Andrades, P. , Figueroa, M. , Sepúlveda, S. , Benitez, S. , Erazo, C. and Danilla, S. (2014) Tumor Recurrence after Negative Pressure Wound Therapy: An Alert Call. Case Reports in Clinical Medicine
, 350-352. doi: 10.4236/crcm.2014.36077
 Ubbink, D.T., Westerbos, S.J., Nelson, E.A., et al. (2008) A Systematic Review of Topical Negative Pressure Therapy for Acute and Chronic Wounds. The British Journal of Surgery, 95, 685-692. http://dx.doi.org/10.1002/bjs.6238
 Webster, J., Scuffham, P., Sherriff, K.L., et al. (2012) Negative Pressure Wound Therapy for Skin Grafts and Surgical Wounds Healing by Primary Intention. Cochrane Database of Systematic Reviews, 4, Article ID: CD009261.
 Hallock, G.G. (2005) Top Ten Reasons to Hate the “V.A.C.”. Plastic and Reconstructive Surgery, 116, 1839. http://dx.doi.org/10.1097/01.prs.0000188840.06911.06
 Mulgrew, S., Khoo, A., Newton, R.M., et al. (2011) Pressure Necrosis Secondary to Negative Pressure Dressing. Annals of the Royal College of Surgeons of England, 93, e27-e28. http://dx.doi.org/10.1308/147870811X580433
 Van Wingerden, J.J., Segers, P. and Jekel, L. (2011) Major Bleeding during Negative Pressure Wound/V.A.C.(R)— Therapy for Postsurgical Deep Sternal Wound Infection—A Critical Appraisal. Journal of Cardiothoracic Surgery, 6, 121. http://dx.doi.org/10.1186/1749-8090-6-121
 Vikatmaa, P., Juutilainen, V., Kuukasjarvi, P., et al. (2008) Negative Pressure Wound Therapy: A Systematic Review on Effectiveness and Safety. European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery, 36, 438-448.
 Sakellariou, V.I., Mavrogenis, A.F. and Papagelopoulos, P.J. (2011) Negative-Pressure Wound Therapy for Musculoskeletal Tumor Surgery. Advances in Skin & Wound Care, 24, 25-30. http://dx.doi.org/10.1097/01.ASW.0000392924.75970.b9
 Orgill, D.P., Manders, E.K., Sumpio, B.E., et al. (2009) The Mechanisms of Action of Vacuum Assisted Closure: More to Learn. Surgery, 146, 40-51. http://dx.doi.org/10.1016/j.surg.2009.02.002
 De Filippo, R.E. and Atala, A. (2002) Stretch and Growth: The Molecular and Physiologic Influences of Tissue Expansion. Plastic and Reconstructive Surgery, 109, 2450-2462. http://dx.doi.org/10.1097/00006534-200206000-00043