AID  Vol.4 No.2 , June 2014
Influenza-Related Hospitalizations and Associated Comorbidities in Nebraska: 2007-2011
Abstract: Objective: Influenza afflicts approximately 5% - 20% of the US population annually. Although prevalence statistics are useful, they are insufficient to understand completely influenza on a health care system. This study estimated Nebraska’s annual hospitalization and comorbidity rates due to influenza from 2007 to 2011. Methods: Influenza was defined according to ICD-9-CM primary codes beginning with 487 or 488 in hospital discharge records. The comorbidities of patients with influenza were defined according to ICD-9-CM secondary diagnosis codes. Results: The highest yearly age-adjusted hospitalization rates were 30.6 and 31.1 per 100,000 populations for 2008 and 2009, respectively. In 2008, the highest hospitalization rate was among those aged 65 yrs and older; in 2009, the highest rate was among those younger than 5 yrs. Asthma was the most frequent comorbidity overall and among those younger than 50 yrs. Conversely, hypertension and heart failure were the most frequent comorbidities among those aged 50 yrs and older. Conclusion: These findings provide a better understanding of the influenza burden and may contribute to developing more effective influenza prevention strategies.
Cite this paper: Han, G. , Gonzalez, S. , Chisanga, C. , Vanicek, C. and Islam, K. (2014) Influenza-Related Hospitalizations and Associated Comorbidities in Nebraska: 2007-2011. Advances in Infectious Diseases, 4, 93-100. doi: 10.4236/aid.2014.42015.

[1]   Division of Public Health (2009) Nebraska Department of Health and Human Services. Nebraska Influenza Prevention Fact Sheet. Issue 4, May 2009.

[2]   Reichert, T.A., Simonsen, L., Sharma, A., Pardo, S.A., Fedson, D.S. and Miller, M.A. (2004) Influenza and the Winter Increase in Mortality in the United States. American Journal of Epidemiology, 5, 492-502.

[3]   Dushoff, J., Plotkin, J.B., Viboud, C., Earn, D.J.D. and Simonsen, L. (2006) Mortality Due to Influenza in the United States an Annualized Regression Approach Using Multiple-Cause Mortality Data. American Journal of Epidemiology, 2, 181-187.

[4]   Monto, A.S. (2004) Global Burden of Influenza: What We Know and What We Need to Know. International Congress Series, 1263, 3-11.

[5]   Nair, H., Brooks, W.A., Katz, M., Roca, A., Berkley, J.A. and Madhi, S.A. (2011) Global Burden of Respiratory Infections Due to seasonal Influenza in Young Children: A Systematic Review and Meta-Analysis. Lancet, 9807, 1917-1930.

[6]   Barker, W.H. (1986) Excess Pneumonia and Influenza Associated Hospitalization during Influenza Epidemics in the United States, 1970-78. American Journal of Public Health, 7, 761-765.

[7]   Glezen, W.P., Greenberg, S.B., Atmar, R.L., Piedra, P.A. and Couch, R.B. (2000) Impact of Respiratory Virus Infections on Persons with Chronic Underlying Conditions. JAMA, 4, 499-505.

[8]   Division of Public Health (2007) Nebraska Department of Health and Human Services. Nebraska Influenza Epidemiology Report. 2004-2007. December 2007.

[9]   Department of Health and Human Services (2014) Division of Public Health. Weekly Influenza Report 2013-14 Influenza Season, Week 17. 2 May 2014.

[10]   Thompson, W.W., Shay, D.K., Weintraub, E., Brammer, L., Bridges, C.B. and Cox, N.J. (2004) Influenza-Associated Hospitalizations in the United States. JAMA, 11, 1333-1340.

[11]   Nebraska Health and Human Services System (2004) Impact of Cardiovascular Disease in Nebraska. Lincoln, NE: Nebraska Health and Human Services System, Department of Health and Human Services, Office of Disease Prevention and Health Promotion.

[12]   Jhung, M.A., Swerdlow, D., Olsen, S.J., Jernigan, D., Biggerstaff, M. and Kamimoto, L. (2011) Epidemiology of 2009 Pandemic Influenza A (H1N1) in the United States. Clinical Infectious Diseases, 52, S13-S26.

[13]   Zarychanski, R., Stuart, T.L., Kumar, A., Doucette, S., Elliott, L., Kettner, J. and Plummer, F. (2010) Correlates of Severe Disease in Patients with 2009 Pandemic Influenza (H1N1) Virus Infection. Canadian Medical Association Journal, 3, 257-264.

[14]   Louie, J.K., Acosta, M., Winter, K., Jean, C., Gavali, S. and Schechter, R. (2009) Factors Associated with Death or Hospitalization Due to Pandemic 2009 Influenza A(H1N1) Infection in California. JAMA, 17, 1896-1902.

[15]   McKenna, J.J., Bramley, A.M., Skarbinski, J., Fry, A.M., Finelli, L. and Jain, S. (2013) Asthma in Patients Hospitalized with Pandemic Influenza A(H1N1)pdm09 Virus Infection-United States, 2009. BMC Infectious Diseases, 57, 1471-2334.

[16]   Bolton, C.E., Ionescu, A.A., Edwards, P.H., Faulkner, T.A., Edwards, S.M. and Shale, D.J. (2005) Attaining a Correct Diagnosis of COPD in General Practice. Respiratory Medicine, 4, 493-500.

[17]   Keren, R., Wheeler, A., Coffin, S.E., Zaoutis, T., Hodinka, R. and Heydon, K. (2006) ICD-9 Codes for Identifying Influenza Hospitalizations in Children. Emerging Infectious Diseases, 10, 1603-1604.