CRCM  Vol.3 No.6 , June 2014
Optic Nerve Metastasis from Breast Carcinoma after Treatment with Taxanes
Abstract: Introduction: The incidence of ocular metastasis from Breast Carcinoma is only between 5% - 30%, mainly located in choroid, but the location in optic nerve is even more infrequent. We present a rare case that combined both locations sequentially in the same eye. Methods: Case report. Results: A 58-year-old woman with advanced breast cancer was referred with a choroidal metastasis in her right eye which responded well to systemic Taxol and Avastin. Afterwards, she developed an optic nerve metastasis in the same eye when she was under the treatment, so it was changed to Docetaxel. Unfortunately the patient didn’t respond to this treatment and died. Conclusions: Choroidal metastasis secondary to breast cancer generally responds well to radiotherapy. Even so, in cases that a great deterioration of visual acuity is expected after radiation, chemotherapy like taxanes is an alternative to preserve vision with complete tumor regression. Nevertheless, the presentation of a second metastasis in optic nerve can be indicative of inadequate treatment of metastatic disease or complication of the treatment, or both.
Cite this paper: Asencio-Duran, M. , Vallejo-Garcia, J. , Rodriguez-Rodriguez, I. , Sánchez-Orgaz, M. and Arbizu-Duralde, Á. (2014) Optic Nerve Metastasis from Breast Carcinoma after Treatment with Taxanes. Case Reports in Clinical Medicine, 3, 336-339. doi: 10.4236/crcm.2014.36074.

[1]   Manquez, M.E., Brown, M.E., Shields, C.L. and Shields, J.A. (2006) Management of Choroidal Metastases from Breast Carcinomas Using Aromatase Inhibitors. Current Opinion in Ophthalmology, 17, 251-256.

[2]   Biswas, J., Ho, T.C. and Bhavsar, K. (2007) Bilateral Metastasis to the Retina, Choroids and Optic Nerve from Breast Cancer: A Clinicopathological Case. Indian Journal of Ophthalmology, 55, 71-72.

[3]   Shields, J.A., Shields, C.L. and Singh, A.D. (2000) Metastatic Neoplasms in the Optic Disc: The 1999 Bjerrum Lecture: Part 2. Archives of Ophthalmology, 118, 217-224.

[4]   Kosmas, C., Malamos, N.A. and Antonopoulos, M. (2000) Complete Regression of Choroidal Metastases from Breast Cancer after Docetaxel-Based Systemic Chemotherapy. Medical and Pediatric Oncology, 34, 229-230.<229::AID-MPO16>3.0.CO;2-U

[5]   Zelek, L., Barthier, S., Riofrio, M., Fizazi, K., Rixe, O., Delord, J.P., Le Cesne, A. and Spielmann, M. (2001) Weekly Vinorelbine Is an Effective Palliative Regimen after Failure with Anthracyclines and Taxanes in Metastatic Breast Carcinoma. Cancer, 92, 2267-2272.<2267::AID-CNCR1572>3.0.CO;2-Q

[6]   Crivellari, D., Pagani, O., Veronesi, A., Lombardi, D., Nolè, F., Thürlimann, B., et al. (2001) International Breast Cancer Study Group. High Incidence of Central Nervous System Involvement in Patients with Metastatic or Locally Advanced Breast Cancer Treated with Epirubicin and Docetaxel. Annals of Oncology, 12, 353-356.