OJPed  Vol.4 No.2 , June 2014
TBXA2R rSNPs, Transcriptional Factor Binding Sites and Asthma in Asians
Abstract: Four regulatory single nucleotide polymorphisms (rSNPs) (rs2238631, rs2238632, rs2238633 and rs2238634) in intron one, two rSNPs (rs1131882 and rs4523) in exon 3 and one rSNP (rs5756) in the 3’UTR of the thromboxane A2 receptor (TBXA2R) gene have been associated with childhood-onset asthma in Asians. These rSNP alleles alter the DNA landscape for potential transcriptional factors (TFs) to attach resulting in changes in transcriptional factor binding sites (TFBS). These TFBS changes are examined with respect to asthma which has been found to be significantly associated with the rSNPs.
Keywords: TBXA2R, rSNPs, TFBS, Asthma
Cite this paper: Buroker, N. (2014) TBXA2R rSNPs, Transcriptional Factor Binding Sites and Asthma in Asians. Open Journal of Pediatrics, 4, 148-161. doi: 10.4236/ojped.2014.42021.

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