OJOG  Vol.4 No.7 , May 2014
A Case Report: Cystic Clear Cell Tumor of Borderline Malignancy of the Ovary
Abstract: Introduction: Ovarian borderline clear cell tumor is a very rare tumor accounting for less than 1% of borderline ovarian tumors. Currently, only 30 cases of borderline clear cell tumors have been reported. This borderline ovarian clear cell tumor often arises from endometriosis. But there are no definitive guidelines for the management of endometriosis with malignant transformation due to a lack of understanding of the mechanistic details that mediate the transformation of endometriosis into ovarian cancer. Case: A 52-year-old woman (G2 P2) who periodically underwent ultraso-nography over the course of 12 years in order to follow the endometrioma present in her left ovary. The diameter of the lesion was 46 mm and it remained largely unchanged. However, a solid region within the ovarian cyst was detected. After the surgery, the final pathological diagnosis was cystic clear cell tumor of borderline malignancy. Conclusion: It reported that risk factors of malignant transformation are older age, postmenopausal status, and larger tumor diameters were associated with a higher prevalence of cancer development. But it is recommended that patients with endometriosis, regardless of patient age or tumor size, undergo careful monitoring to detect changes in growth or the formation of solid regions for as long as the lesion is present.
Cite this paper: Matsubara, Y. , Fujioka, T. , Matsubara, K. and Nawa, A. (2014) A Case Report: Cystic Clear Cell Tumor of Borderline Malignancy of the Ovary. Open Journal of Obstetrics and Gynecology, 4, 391-394. doi: 10.4236/ojog.2014.47058.

[1]   Kobayashi, H., Sumimoto, K., Kitanaka, T., et al. (2008) Ovarian Endometrioma—Risks Factors of Ovarian Cancer Development. European Journal of Obstetrics & Gynecology and Reproductive Biology, 138, 187-193.

[2]   Rogers, P.A., D’Hooghe, T.M., Fazleabas, A., et al. (2009) Priorities for Endometriosis Research: Recommendations from an International Consensus Workshop. Reproductive Sciences, 16, 335-346.

[3]   Kobayashi, H., Sumimoto, K., Moniwa, N., et al. (2007) Risk of Developing Ovarian Cancer among Women with Ovarian Endometrioma: A Cohort Study in Shizuoka, Japan. International Journal of Gynecological Cancer, 17, 37-43.

[4]   Mandai, M., Matsumura, N., Baba, T., et al. (2011) Ovarian Clear Cell Carcinoma as a Stress-Responsive Cancer: Influence of the Microenvironment on the Carcinogenesis and Cancer Phenotype. Cancer Letters, 310, 129-133.

[5]   Uzan, C., Dufeu-Lefebvre, M., Fauvet, R., et al. (2012) Management and Prognosis of Clear Cell Borderline Ovarian Tumor. International Journal of Gynecological Cancer, 22, 993-999.