ABB  Vol.2 No.2 , April 2011
Anti-yeast activities of Origanum oil against human pathogenic yeasts
ABSTRACT
Outbreak of autoimmune diseases by pathogenic yeasts has led to a serious medical threat. As these organisms evolve resistance to existing antifungal drugs, the concern could be further compounded. The realm of plant derived products offers a wide spectrum of potentially valuable alternatives to the existing synthetic fungicides. Essential oils from sev-eral medicinal plants have been shown to exhibit pharmacological attributes. In the present study, anti-yeast properties of Oregano essential oil (OEO) were examined in vitro against four human patho-genic yeasts i.e., Candida albicans, Cryptococcus al-bidus, Cryptococcus neoformans and Rhodotorula ru-brum. OEO concentration of 200 μg/mL was found to be growth inhibitory against all four yeasts examined, thereby showing its potential to function as a natural anti-yeast agent.

Cite this paper
nullAdams, A. , Kumar, S. , Clauson, J. and Sahi, S. (2011) Anti-yeast activities of Origanum oil against human pathogenic yeasts. Advances in Bioscience and Biotechnology, 2, 103-107. doi: 10.4236/abb.2011.22016.
References
[1]   Bruneton, J. (1999) Pharmacognosy, phytochemistry, medicinal plants. Intercept Ltd, London, Paris, New York.

[2]   Kaufman, H.K. (1997) Opportunistic fungal infections: Superficial and systemic candidiasis. Geriatrics, 52, 50-54.

[3]   Manohar, V., Ingram, C., Gray, J., Talpur, N.A., Echard, B.W., Bagchi, D. and Preuss, H.G. (2001) Antifungal activities of origanum oil against Candida albicans. Molecular and Cellular Biochemistry, 228, 111-117. doi:10.1023/A:1013311632207

[4]   Mandala, S.M., Thornton, R.A., Milligan, J., Rosenbach, M., Garcia-Calvo, M., Bull, H.G., Harris, G., Flattery, A.M., Gill, C.G., Bartizal, K., Dreikon, S. and Kurtz, M.B. (1998) Rustmicin, a potent antifungal agent inhibits sphingolipid synthesis at inositol phosphoceramide synthase. Journal of Biological Chemistry, 273, 14942-14949. doi:10.1074/jbc.273.24.14942

[5]   Scorzoni, L., Benaduccil,T., Almeida, A., Sliva, D., Bolzani, V. and Gianinni, M. (2007) The use of standard methodology for determination of antifungal activity of natural products against medical yeasts Candida sp. Brazilian Journal of Microbiology, 38, 391-397. doi:10.1590/S1517-83822007000300001

[6]   Lawrence, B.M. (1984) The botanical and chemical aspects of Oregano. Perfume and Flavor, 9, 41-52.

[7]   Lukas,B., Schmiderer, C., Mitteregger, U., Franz, C. and Novak, J. (2008) Essential oil compounds of Origanum vulgare (Lamiaceae) from Corsica. Natural Product Communications, 12, 1127-1131.

[8]   Bozin, B., Mimica-Dukic, N., Simin, N. and Anackov, G. (2006) Characterization of the volatile composition of essential oils of some Lamiceae spices and antimicrobial and antioxidant activities of the entire oil. Journal of Agricultural and Food Chemistry, 54, 1822-1828. doi:10.1021/jf051922u

[9]   Paster, N., Juven, B.J., Shaaya, E., Menasherov, M., Nitzan, R., Weisslowicz, H. and Ravid U. (1990) Inhibitory effect of oregano and thyme essential oils on moulds and food borne bacteria. Letters in Applied Microbiology, 11, 33-37. doi:10.1111/j.1472-765X.1990.tb00130.x

[10]   Tampieri, M.P., Galuppi, R., Macchioni, F., Carelle, M.S., Falcioni, L., Cioni, P.L. and Morelli, I. (2005) The inhibition of Candida albicans by selected essential oils and their major components. Mycopathologia, 159, 339-345. doi:10.1007/s11046-003-4790-5

[11]   Adam, K., Sivropoulou, A., Kokkini, S., Lanaras, T. and Arsenakis, M. (1998) Antifungal activities of Origanum vulgare susp Hirtum, Mentha spicata, Lavandula angustifolia and Salvia fruticosa essential oils against human pathogenic fungi. Journal of Agricultural and Food Chemistry, 46, 1739-1745. doi:10.1021/jf9708296

[12]   Fromtling, R. and Bulmer, G. (1978) In vitro effect of aqueous extract of garlic (Allium sativum) on the growth and viability of Cryptococcus neoformans. Mycologia, 70, 390-397. doi:10.2307/3759038

[13]   Bartner, A., Pfeiffer, K.P. and Batner, H. (1994) Applicability of disc diffusion methods required by the pharmacopoeias for testing antibacterial activity of natural compound. Pharmazie, 49, 512-516.

[14]   Voda, K., Boh, B., Vrtaznik, M. and Pohleven, F. (2003) Effect of the antifungal activity of oxygenated aromatic essential oil compounds on the white-rot Trametes versicolor and the brown rot Coniophora puteana. International Journal of Biodeterioration and Biodegradation, 51, 51-59. doi:10.1016/S0964-8305(02)00075-6

[15]   Radudiene, J., Judpintiene, A. Peeiulyte, D. and Janulis, V. (2005) Chemical composition and antimicrobial activity of Origanum vulgare. Biologia, 4, 53-58.

[16]   Bennis, S., Chami, F., Chami, N., Bouchikhi, T. and Remmal, A. (2004) Surface alteration of Saccaromyces cervisiae induced by thymol and eugenol. Letters in Applied Microbiology, 38, 454-458. doi:10.1111/j.1472-765X.2004.01511.x

 
 
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