Background: Minimally invasive esophagectomy nowadays is replacing the classic open technique. Additional studies are needed to confirm its safety and efficacy. Methods: thirty patients with esophageal carcinoma were enrolled in this study. Patients were evaluated preoperatively and they underwent thoracoscopic and laparoscopic procedures for assessment of resectability. Resectablepatients underwent radical esophagectomy with gastric tube reconstruction through a four-cm neck incision. Results: 17 patients were operable and 13 patients were inoperable. The mean operative time for the whole procedure was 5.97 ± 1.66 hours. The mean blood loss was 250 ± 138.07 cc. The mean overall hospital stay was 17.47 ± 5.49 daysdays. Common postoperative complications included pneumonia (13.3%) pleural effusion (6.7%), cervical anastomotic leakage (10%), and wound infection (13.3%). One patient died in the early postoperative period. Conclusions: we conclude that totallyendoscopic (thoracoscopic and laparoscopic) esophagectomy is feasible and relatively safe technique. Beside its efficacy as an assessment tool, total esophagectomy and lymphadenectomy could be performed in the same time.
 Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C. and Parkin, D.M. (2010) Estimates of Worldwide Burden of Cancer in 2008: GLOBOCAN 2008. International Journal of Cancer, 127, 2893-2917. http://dx.doi.org/10.1002/ijc.25516
 Holmes, R.S. and Vaughan, T.L. (2007) Epidemiology and Pathogenesis of Esophageal Cancer. Seminars in Radiation Oncology, 17, 2-9. http://dx.doi.org/10.1016/j.semradonc.2006.09.003
 Lerut, T., Coosemans, W., De Leyn, P., Van Raemdonck, D., Nafteux, P. and Moons, J. (2001) Optimizing Treatment of Carcinoma of the Esophagus and Gastroesophageal Junction. Surgical Oncology Clinics of North America, 10, 863-884.
 Ben-David, K., Sarosi, G.A., Cendan, J.C., Howard, D., Rossidis, G. and Hochwald, S.N. (2012) Decreasing Morbidity and Mortality in 100 Consecutive Minimally Invasive Esophagectomies. Surgical Endoscopy, 26, 162-167. http://dx.doi.org/10.1007/s00464-011-1846-3
 Dantoc, M.M., Cox, M.R. and Eslick, G.D. (2012) Does Minimally Invasive Esophagectomy (Mie) Provide for Comparable Oncologic Outcomes to Open Techniques? A Systematic Review. Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract, 16, 486-494.
 Benzoni, E., Terrosu, G., Bresadola, V., Uzzau, A., Intini, S., Noce, L., Cedolini, C., Bresadola, F. and De Anna, D. (2004) A Comparative Study of the Transhiatal Laparoscopic Approach versus Laparoscopic Gastric Mobilisation and Right Open Transthoracic Esophagectomy for Esophageal Cancer Management. Journal of Gastrointestinal and Liver Diseases, 16, 395-401.
 Elewa, H.H. (2010) Potentialities of Water Resources Pollution of the Nile River Delta, Egypt. The Open Hydrology Journal, 4, 1-13. http://dx.doi.org/10.2174/1874378101004010001
 Gao, Y., Wang, Y., Chen, L. and Zhao, Y. (2011) Comparison of Open Three-Field and Minimally-Invasive Esophagectomy for Esophageal Cancer. Interactive Cardiovascular and Thoracic Surgery, 12, 366-369. http://dx.doi.org/10.1510/icvts.2010.258632
 Kinjo, Y., Kurita, N., Nakamura, F., Okabe, H., Tanaka, E., Kataoka, Y., Itami, A., Sakai, Y. and Fukuhara, S. (2012) Effectiveness of Combined Thoracoscopic-Laparoscopic Esophagectomy: Comparison of Postoperative Complications and Midterm Oncological Outcomes in Patients with Esophageal Cancer. Surgical Endoscopy, 26, 381-390. http://dx.doi.org/10.1007/s00464-011-1883-y
 Schoppmann, S.F., Prager, G., Langer, F.B., Riegler, F.M., Kabon, B., Fleischmann, E. and Zacherl, J. (2010) Open versus Minimally Invasive Esophagectomy: A Single-Center Case Controlled Study. Surgical Endoscopy, 24, 3044-3053. http://dx.doi.org/10.1007/s00464-010-1083-1
 Berger, A.C., Bloomenthal, A., Weksler, B., Evans, N., Chojnacki, K.A., Yeo, C.J. and Rosato, E.L. (2011) Oncologic Efficacy Is not Compromised, and May Be Improved with Minimally Invasive Esophagectomy. Journal of the American College of Surgeons, 212, 560-568.
 Palanivelu, C., Prakash, A., Senthilkumar, R., Senthilnathan, P., Parthasarathi, R., Rajan, P.S. and Venkatachlam, S. (2006) Minimally Invasive Esophagectomy: Thoracoscopic Mobilization of the Esophagus and Mediastinal Lymphadenectomy in Prone Position—Experience of 130 Patients. Journal of the American College of Surgeons, 203, 7-16.
 Mamidanna, R., Bottle, A., Aylin, P., Faiz, O. and Hanna, G.B. (2012) Short-Term Outcomes Following Open versus Minimally Invasive Esophagectomy for Cancer in England: A Population-Based National Study. Annals of Surgery, 255, 197-203. http://dx.doi.org/10.1097/SLA.0b013e31823e39fa
 Smithers, B.M., Gotley, D.C., Martin, I. and Thomas, J.M. (2007) Comparison of the Outcomes between Open and Minimally Invasive Esophagectomy. Annals of Surgery, 245, 232-240.
 Zingg, U., McQuinn, A., DiValentino, D., Esterman, A.J., Bessell, J.R., Thompson, S.K., Jamieson, G.G. and Watson, D.I. (2009) Minimally Invasive versus Open Esophagectomy for Patients with Esophageal Cancer. The Annals of Thoracic Surgery, 87, 911-919.
 Sundaram, A., Geronimo, J.C., Willer, B.L., Hoshino, M., Torgersen, Z., Juhasz, A., Lee, T.H. and Mittal, S.K. (2012) Survival and Quality of Life after Minimally Invasive Esophagectomy: A Single-Surgeon Experience. Surgical Endoscopy, 26, 168-176. http://dx.doi.org/10.1007/s00464-011-1850-7
 Singh, R.K., Pham, T.H., Diggs, B.S., Perkins, S. and Hunter, J.G. (2011) Minimally Invasive Esophagectomy Provides Equivalent Oncologic Outcomes to Open Esophagectomy for Locally Advanced (Stage II or III) Esophageal Carcinoma. Archives of Surgery, 146, 711-714.