Health  Vol.6 No.11 , May 2014
Effects of the Mixture of Cichorium intybus L. and Cinnamomum zeylanicum on Hepatic Enzymes Activity and Biochemical Parameters in Patients with Nonalcoholic Fatty Liver Disease
Abstract: The prevalence of nonalcoholic fatty liver disease (NAFLD) as a metabolic disorder affecting the liver function is rapidly increasing and there is a need to develop new and more efficient treatment. This study was designed to evaluate the protective effect of Cichorium intybus L. and Cinnamon mixture infusion (2.5 and 0.5 g/100mL and twice/day) on patients with NAFLD. This before-after clinical trial study was performed on 25 patients with NAFLD. They were administered the mixture of extract prepared in special bags twice a day for 30 days. Hepatic and metabolic markers of NAFLD like alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), fasting blood sugar (FBS), cholesterol (chol), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) in plasma and also, fatty liver ultrasonographic grading were determined before and after using the extracts. 30-day treatment with extracts in NAFLD patients resulted in a significant decrease in ALT and AST. FBS, TG and ALP were also decreased after administration of the extracts but not significantly. A significant linear correlation was found between age and ALP, and between gender and liver enzymes. It is concluded that the mixture of Cichorium intybus L. and Cinnamon extracts has some benefits in NAFLD patients making them valuable for future investigations.
Cite this paper: Asl, Z. , Malekirad, A. , Abdollahi, M. , Bakhshipour, A. , Dastjerdi, H. , Mostafalou, S. and Poor, R. (2014) Effects of the Mixture of Cichorium intybus L. and Cinnamomum zeylanicum on Hepatic Enzymes Activity and Biochemical Parameters in Patients with Nonalcoholic Fatty Liver Disease. Health, 6, 1212-1217. doi: 10.4236/health.2014.611148.

[1]   Vuppalanchi, R. and Chalasani, N. (2009) Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: Selected Practical Issues in Their Evaluation and Management. Hepatology, 49, 306-317.

[2]   Erickson, S.K. (2009) Nonalcoholic Fatty Liver Disease. Journal of Lipid Research, 50, S412-S416.

[3]   Schreuder, T.C., Verwer, B.J., van Nieuwkerk, C.M. and Mulder, C.J. (2008) Nonalcoholic Fatty Liver Disease: An Overview of Current Insights in Pathogenesis, Diagnosis and Treatment. World Journal of Gastroenterology, 14, 2474-2486.

[4]   Anderson, R.A. (2008) Chromium and Polyphenols from Cinnamon Improve Insulin Sensitivity. Proceedings of the Nutrition Society, 67, 48-53.

[5]   Kirkham, S., Akilen, R., Sharma, S. and Tsiami, A. (2009) The Potential of Cinnamon to Reduce Blood Glucose Levels in Patients with Type 2 Diabetes and Insulin Resistance. Diabetes, Obesity and Metabolism, 11, 1100-1113.

[6]   Qin, B., Panickar, K.S. and Anderson, R.A. (2010) Cinnamon: Potential Role in the Prevention of Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes. Journal of Diabetes Science and Technology, 4, 685-693.

[7]   Couturier, K., Qin, B., Batandier, C., Awada, M., Hininger-Favier, I., Canini, F., Leverve, X., Roussel, A.M. and Anderson, R.A. (2011) Cinnamon Increases Liver Glycogen in an Animal Model of Insulin Resistance. Metabolism, 60, 1590-1597.

[8]   Ranasinghe, P., Jayawardana, R., Galappaththy, P., Constantine, G.R., de Vas Gunawardana, N. and Katulanda, P. (2012) Efficacy and Safety of “True” Cinnamon (Cinnamomum zeylanicum) as a Pharmaceutical Agent in Diabetes: A Systematic Review and Meta-Analysis. Diabetic Medicine, 29, 1480-1492.

[9]   Muthusamy, V.S., Saravanababu, C., Ramanathan, M., Bharathi Raja, R., Sudhagar, S., Anand, S. and Lakshmi, B.S. (2010) Inhibition of Protein Tyrosine Phosphatase 1B and Regulation of Insulin Signalling Markers by Caffeoyl Derivatives of Chicory (Cichorium intybus) Salad Leaves. British Journal of Nutrition, 104, 813-823.

[10]   Ghamarian, A., Abdollahi, M., Su, X., Amiri, A., Ahadi, A. and Nowrouzi, A. (2012) Effect of Chicory Seed Extract on Glucose Tolerance Test (GTT) and Metabolic Profile in Early and Late Stage Diabetic Rats. Journal of Pharmaceutical Sciences, 20, 56.

[11]   Jurgonski, A., Juskiewicz, J., Zdunczyk, Z. and Krol, B. (2012) Caffeoylquinic Acid-Rich Extract from Chicory Seeds Improves Glycemia, Atherogenic Index, and Antioxidant Status in Rats. Nutrition, 28, 300-306.

[12]   Minaiyan, M., Ghannadi, A.R., Mahzouni, P. and Abed, A.R. (2012) Preventive Effect of Cichorium intybus L. Two Extracts on Cerulein-Induced Acute Pancreatitis in Mice. International Journal of Preventive Medicine, 3, 351-357.

[13]   Ziamajidi, N., Khaghani, S., Hassanzadeh, G., Vardasbi, S., Ahmadian, S., Nowrouzi, A., Ghaffari, S.M. and Abdirad, A. (2013) Amelioration by Chicory Seed Extract of Diabetes- and Oleic Acid-Induced Non-Alcoholic Fatty Liver Disease (NAFLD)/Non-Alcoholic Steatohepatitis (NASH) via Modulation of PPARalpha and SREBP-1. Food and Chemical Toxicology, 58, 198-209.

[14]   Panickar, K.S., Polansky M.M. and Anderson, R.A. (2009) Cinnamon Polyphenols Attenuate Cell Swelling and Mitochondrial Dysfunction Following Oxygen-Glucose Deprivation in Glial Cells. Experimental Neurology, 216, 420-427.

[15]   Malekirad, A.A., Mojtabaee, M., Faghih, M., Vaezi, G. and Abdollahi, M. (2012) Effects of the Mixture of Melissa officinalis L., Cinnamomum zeylanicum and Urtica dioica on Hepatic Enzymes Activity in Patients with Nonalcoholic Fatty Liver Disease. International Journal of Pharmacology, 8, 204-208.

[16]   Moselhy, S.S. and Ali, H.K. (2009) Hepatoprotective Effect of Cinnamon Extracts against Carbon Tetrachloride Induced Oxidative Stress and Liver Injury in Rats. Biological Research, 42, 93-98.

[17]   Ahmed, B., Khan, S., Masood, M.H. and Siddique, A.H. (2008) Anti-Hepatotoxic Activity of Cichotyboside, a Sesquiterpene Glycoside from the Seeds of Cichorium intybus. Journal of Asian Natural Products Research, 10, 223-231.

[18]   Gilani, A.H., Janbaz, K.H. and Shah, B.H. (1998) Esculetin Prevents Liver Damage Induced by Paracetamol and CCL4. Pharmacological Research, 37, 31-35.