JCDSA  Vol.4 No.3 , June 2014
Preliminary Colorimetric Assessment of Progressive Nonsegmental Vitiligo under Short-Term Intravenous Methylprednisolone Pulse Therapy
Abstract: Although the administration of systemic steroid for nonsegmental vitiligo in the progressive stage is a recommended treatment according to guidelines, the clinical efficacy of this regimen has not been fully established. In this study, we evaluated the clinical efficacy of half-dose steroid treatment and stratified the evidence regarding its usefulness in progressive vitiligo patients. Half-dose steroid pulse therapy (500 mg/day of methylprednisolone for three sequential days) was administered intravenously three times monthly in five vitiligo patients. The visual changes in vitiligo lesions were evaluated on photographs and quantified using a spectrophotometer. As results, all patients completed three cycles of treatment without severe adverse events. Three of the five patients achieved disease arrest with decrease in white contrast. Therefore, short-term and halfdose steroid therapy is well tolerated and effective for achieving disease arrest in progressive nonsegmental vitiligo. The whiteness assessed by a spectrophotometer is possibly associated with therapeutic response to steroid therapy.
Cite this paper: Nagata, Y. , Tanemura, A. , Ono, E. , Tanaka, A. , Kato, K. , Yamada, M. and Katayama, I. (2014) Preliminary Colorimetric Assessment of Progressive Nonsegmental Vitiligo under Short-Term Intravenous Methylprednisolone Pulse Therapy. Journal of Cosmetics, Dermatological Sciences and Applications, 4, 135-140. doi: 10.4236/jcdsa.2014.43019.

[1]   Taieb, A., Alomar, A., Bohm, M., Dell’Anna, M.L., De Pase, A., Elefttheriadou, V., Ezzedine, K., Gauthier, Y., Gawkrodger, D.J., Jouary, T., Leone, G., Moretti, S., Nieuweboer-Krobotova, L., Olsson, M.J., Parsad, D., Passeron, T., Tanew, A., van der Veen, W., van Geel, N., Whitton, M., Wolkerstorfer, A. and Picardo, M. (2013) Guidelines for the Management of Vitiligo: The European Dermatology Forum Consensus. British Journal of Dermatology, 168, 5-19.

[2]   Oiso, N., Suzuki, T., Wataya-Kaneda, M., Tanemura, A., Tanioka, M., Fujimoto, T., Fukai, K., Kawakami, T., Tsukamoto, K., Yamaguchi, Y., Sano, S., Mitsuhashi, Y., Nishigori, C., Morita, A., Nakagawa, H., Mizoguchi, M. and Katayama, I. (2013) Guidelines for the Diagnosis and Treatment of Vitiligo in Japan. Journal of Dermatology, 40, 1-11.

[3]   Radakovic-Fijan, S., Fürnsinn-Friedl, A.M., Honigsmann, H. and Tanew, A. (2001) Oral Dexamethasone Pulse Treatment for Vitiligo. Journal of American Academy of Dermatology, 44, 814-817.

[4]   Kim, S.M., Lee, H.S. and Hann, S.K. (1999) The Efficacy of Low-Dose Oral Corticosteroids in the Treatment of Vitiligo Patients. International Journal of Dermatology, 38, 546-550.

[5]   Pasricha, J.S. and Khaitan, B.K. (1993) Oral Mini-Pulse Therapy with Betamethasone in Vitiligo Patients Having Extensive or Fast-Spreading Disease. International Journal of Dermatology, 32, 753-757.

[6]   Seiter, S., Ugurel, S., Tilgen, W. and Reinhold, U. (2000) Use of High-Dose Methylprednisolone Pulse Therapy in Patients with Progressive and Stable Vitiligo. International Journal of Dermatology, 39, 624-627.

[7]   Hertz, K.C., Gazze, L.A., Kirkpatrick, C.H. and Katz, S.I. (1977) Autoimmune Vitiligo: Detection of Antibodies to Melanin-Producing Cells. New England Journal of Medicine, 297, 634-637.

[8]   Barret, D.F. and Lee, H.A. (1982) Corticosteroid Pulse Therapy in Dermatology. British Journal of Dermatology, 107, 31.

[9]   Lee, Y., Seo, Y.J., Lee, J.H. and Park, J.K. (2007) High-Dose Prednisolone and Psoralen Ultraviolet A Combination Therapy in 36 Patients with Vitiligo. Clinical and Experimental Dermatology, 32, 499-501.

[10]   Tanemura, A., Takahashi, A., Ueki, Y., Murota, H., Yamaguchi, Y. and Katayama, I. (2012) Therapeutic Comparison between Sun Irradiation vs. Narrowband UVB Phototherapy along with Topical Tacalcitol for Vitiligo Vulgaris. Journal of Cosmetics, Dermatological Sciences and Applications, 2, 88-91.

[11]   Jian, D., Jiang, D., Su, J., Chen, W., Hu, X., Kuang, Y., Xie, H., Li, J. and Chen, X. (2011) Diethylstilbestrol Enhances Melanogenesis via cAMP-PKA-Mediating Up-Regulation of Tyrosinase and MITF in Mouse B16 Melanoma Cells. Steroids, 76, 1297-1304.

[12]   Birlea, S.A., Costin, G.E. and Norris, D.A. (2009) New Insights on Therapy with Vitamin D Analogs Targeting the Intracellular Pathways That Control Repigmentation in Human Vitiligo. Medicinal Research Reviews, 29, 514-546.