FNS  Vol.5 No.10 , May 2014
Effects of Intake of Milk Enriched with Aloe vera on Patients with Gastrointestinal Reflux Disease
Abstract: Background: Aloe vera has been used by many civilizations throughout history due to the numerous properties attributed. Gastro oesophageal reflux disease is a common disorder with consequences for the patient’s health related quality of life. Aims: The purpose of this study was to assess the benefits of the Aloe vera in 80 patients with gastro oesophageal reflux. Methods: This is probably the first randomised and double-blind trail ever performed on this subject. The study included eight weeks of treatment with milk enriched with Aloe vera or placebo. Data of diet (frequency questionnaire), symptoms (gastrointestinal symptom rating scale) and quality of life (quality of life in reflux and disease) were obtained. Results: So far, there has been hardly any proof that Aloe vera decreases symptoms of reflux disease; on the contrary, a lower percentage of remission of pain is observed among the Aloe vera group. As long as its effectiveness has not been proven properly, the use of Aloe vera in reflux disease cannot be recommend. Conclusion: Aloe vera does not have a beneficial effect on reflux disease under the study conditions.
Cite this paper: Sangil-Monroy, M. , Serra-Majem, L. , Monroy, J. , Andrellucchi, A. , Sánchez-Villegas, A. , Doreste, J. and Knipschild, P. (2014) Effects of Intake of Milk Enriched with Aloe vera on Patients with Gastrointestinal Reflux Disease. Food and Nutrition Sciences, 5, 936-942. doi: 10.4236/fns.2014.510104.

[1]   Vogler, B.K. and Ernst, E. (1999) Aloe vera: A Systematic Review of Its Clinical Effectiveness. The British Journal of General Practice, 49, 823-828.

[2]   Grindlay, D. and Reynolds, T. (1986) The Aloe vera Phenomenon: A Review of the Properties and Modern Uses of Leaf Parenchyma Gel. Journal of Ethnopharmacology, 16, 117-151.

[3]   Langmead, L., Feakins, R.M., Goldthorpe, S., et al. (2004) Randomized, Double-Blind, Placebo-Controlled Trial of Oral Aloe vera gel for Ulcerative Colitis. Alimentary Pharmacology & Therapeutics, 19, 739-747.

[4]   Blitz, J., Smith, J.W. and Gerard, J.R. (1963) Aloe vera Gel in Peptic Ulcer Therapy: Preliminary Report. Journal of the American Osteopathic Association, 62, 731-735.

[5]   Eshun, K. and He, Q. (2004) Aloe vera: A Valuable Ingredient for the Food, Pharmaceutical and Cosmetic Industries—A Review. Critical Reviews in Food Science and Nutrition, 44, 91-96.

[6]   Kahrilas, P.J. (2008) Gastroesophageal Reflux Disease. The New England Journal of Medicine, 359, 1700-1707.

[7]   Lagergren, J. and Bergstrom, N.O. (2000) No Relation between Body Mass and Gastro-Oesophageal Reflux Symptoms in a Swedish Population Based Study. Gut, 47, 26-29.

[8]   Van Pinxteren, B., Numans, M.E., Lau, J., et al. (2003) Short-Term Treatment of Gastroesophageal Reflux Disease. Journal of General Internal Medicine, 18, 755-763.

[9]   El-Serag, H.B., Sonnenberg, A., Jamal, M.M., et al. (1999) Corpus Gastritis Is Protective against Reflux Oesophagitis. Gut, 45, 181-185.

[10]   (2012) Ficha Técnica o Resumen de las Características del Producto: Almax (Internet). Espana: Agencia Espanola del Medicamento y Productos Sanitarios.

[11]   Revicki, D.A., Word, M., Winklun, I., et al. (1998) Reliability and Validity of Gastrointestinal Symptom Rating Scale en Patients with Gastroesophageal Reflux Disease. Quality of Life Research, 7, 75-83.

[12]   Revicki, D.A., Sorensen, S., Maton, P.N., et al. (1998) Health-Related Quality of Life Outcomes of Omeprazole versus Ranitidine in Poorly Responsive Symptomatic Gastroesophageal Reflux Disease. Digestive Diseases, 16, 284-291.

[13]   Havelund, T., Lind, T., Wiklund, I., et al. (1999) Quality of Life in Patients with Heartburn but without Esophagitis: Effects of Treatment with Omeprazole. The American Journal of Gastroenterology, 94, 1782-1789.

[14]   Moreno Elola-Olaso, C., Rey, E., Rodríguez-Artalejo, F., et al. (2002) Adaptación y Validación de un Cuestionario Sobre Reflujo Gastroesofágico para Uso en Población Espanola. Revista Espanola de Enfermedades Digestivas, 94, 745-751.

[15]   Kulich, K.R., Piqué, J.M., Vegazo, O., et al. (2005) Psychometric Validation of the Spanish Translation of Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) Questionnaire in Patients with Reflux Disease. Espanola Clínica Espanola, 205, 588-594.

[16]   Talley, N.J., Fullerton, S., Junghard, O., et al. (2001) Quality of Life in Patients with Endoscopy-Negative Heartburn: Reliability and Sensitivity of Disease-Specific Instruments. The American Journal of Gastroenterology, 96, 1998-2004.

[17]   Kulig, M., Leodolter, A., Vieth, M., et al. (2003) Quality of Life in Relation to Symptoms in Patients with Gastroesophageal Reflux Disease: An Analyses Based on the Pro-GERD Initiative. Alimentary Pharmacology & Therapeutics, 18, 767-776.

[18]   Williamson, G., Coppens, P., Serra-Majem, L., et al. (2011) Review of the Efficacy of Green Tea, Isoflavones and Aloe vera Supplements Based on Randomised Controlled Trials. Food & Function, 2, 753-759.

[19]   Sifrim, D. (2005) Relevance of Volume and Proximal Extent of Reflux in Gastro-Oesophageal Reflux Disease. Gut, 54, 175-178.

[20]   Garcia-Alvarez, A., Egan, B., de Klein, S., et al. (2014) Usage of Plant Food Supplements across Six European Countries: Findings from the PlantLIBRA Consumer Survey. PLoS One, 9, Article ID: e92265.