The objective of this
study was to examine whether stimulants impact pubertal development in
adolescent Attention Deficit Hyperactivity Disorder (ADHD), an understudied
subject. Pubertal staging data were collected during a 2-year open study of
extended release methylphenidate in adolescents (N = 111)
with ADHD. Tanner stages were compared to national estimates. The sample was
primarily male, Caucasian, and a mean age of 14.8 years at baseline. The
baseline Tanner stage for 70% of subjects was consistent with chronological
age. For the majority of subjects who reached 12 - 20
months (N = 25) or 24 months (N = 21)
endpoints, the Tanner stage at respective endpoints was consistent with age. We
found that progression in Tanner
stage was not associated with OROS MPH duration or dose (p > 0.10).
Long-term treatment with extended release methylphenidate did not appear to
adversely impact pubertal development in this sample of adolescents with ADHD.
Cite this paper
Hammerness, P. , Geller, D. , Joshi, G. , Georgiopoulos, A. , Doyle, R. , Spencer, T. , Petty, C. , Mahoney, L. and Biederman, J. (2014) Impact of Long-Term Treatment with OROS Methylphenidate on Pubertal Development in Adolescents with ADHD. Open Journal of Psychiatry
, 147-152. doi: 10.4236/ojpsych.2014.42019
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