Back
 OJPsych  Vol.4 No.2 , April 2014
Impact of Long-Term Treatment with OROS Methylphenidate on Pubertal Development in Adolescents with ADHD
Abstract: The objective of this study was to examine whether stimulants impact pubertal development in adolescent Attention Deficit Hyperactivity Disorder (ADHD), an understudied subject. Pubertal staging data were collected during a 2-year open study of extended release methylphenidate in adolescents (N = 111) with ADHD. Tanner stages were compared to national estimates. The sample was primarily male, Caucasian, and a mean age of 14.8 years at baseline. The baseline Tanner stage for 70% of subjects was consistent with chronological age. For the majority of subjects who reached 12 - 20 months (N = 25) or 24 months (N = 21) endpoints, the Tanner stage at respective endpoints was consistent with age. We found that progression in Tanner stage was not associated with OROS MPH duration or dose (p > 0.10). Long-term treatment with extended release methylphenidate did not appear to adversely impact pubertal development in this sample of adolescents with ADHD.
Cite this paper: Hammerness, P. , Geller, D. , Joshi, G. , Georgiopoulos, A. , Doyle, R. , Spencer, T. , Petty, C. , Mahoney, L. and Biederman, J. (2014) Impact of Long-Term Treatment with OROS Methylphenidate on Pubertal Development in Adolescents with ADHD. Open Journal of Psychiatry, 4, 147-152. doi: 10.4236/ojpsych.2014.42019.
References

[1]   Visser, S.N., Bitsko, R.H., Danielson, M.L., Perou, R. and Blumberg, S.J. (2010) Increasing Prevalence of Parent-Reported Attention-Deficit/Hyperactivity Disorder among Children—United States 2003-2007. Morbidity and Mortality Weekly Report (MMWR), 59, 1439-1443.

[2]   Faraone, S.V., Sergeant, J., Gillberg, C. and Biederman, J. (2003) The Worldwide Prevalence of ADHD: Is It an American Condition? World Psychiatry, 2, 104-113.

[3]   Brown, R.T., et al. (2005) Treatment of Attention-Deficit/Hyperactivity Disorder: Overview of the Evidence. Pediatrics, 115, e749-757. http://dx.doi.org/10.1542/peds.2004-2560

[4]   Pliszka, S. (2007) Practice Parameter for the Assessment and Treatment of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 894-921.

[5]   Faraone, S.V., Biederman, J., Morley, C.P. and Spencer, T.J. (2008) Effect of Stimulants on Height and Weight: A Review of the Literature. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 994-1009. http://dx.doi.org/10.1097/CHI.0b013e31817e0ea7

[6]   Poulton, A. (2006) Growth and Sexual Maturation in Children and Adolescents with Attention Deficit Hyperactivity Disorder. Current Opinion in Pediatrics, 18, 427-434.
http://dx.doi.org/10.1097/01.mop.0000236394.94827.4c

[7]   Spencer, T., et al. (1996) Growth Deficits in ADHD Children Revisited: Evidence for Disorder-Associated Growth Delays? Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1460-1469. http://dx.doi.org/10.1097/00004583-199611000-00014

[8]   Hammerness, P., et al. (2013) Do Stimulants Reduce the Risk for Cigarette Smoking in Youth with Attention-Deficit Hyperactivity Disorder? A Prospective, Long-Term, Open-Label Study of Extended-Release Methylphenidate. Journal of Pediatrics, 162, 22-27.

[9]   Marshall, W.A. and Tanner, J.M. (1969) Variations in Pattern of Pubertal Changes in Girls. Archives of Disease in Childhood, 44, 291-303. http://dx.doi.org/10.1136/adc.44.235.291

[10]   Marshall, W.A. and Tanner, J.M. (1970) Variations in the Pattern of Pubertal Changes in Boys. Archives of Disease in Childhood, 45, 13-23. http://dx.doi.org/10.1136/adc.45.239.13

[11]   Sun, S.S., et al. (2002) National Estimates of the Timing of Sexual Maturation and Racial Differences among Us Children. Pediatrics, 110, 911-919. http://dx.doi.org/10.1542/peds.110.5.911

 
 
Top