Background: Fibrocystic disease of the
breast in one of the commonest diseases in
women above 30 years of age. The assumption of it being innocuous and benign is
questionable with increased incidence of malignancies developing in these
women. Introduction: Understanding the pathophysiology of fibrocystic disease
is essential for identifying determinants of malignant change. Case Report: A
case of carcinoma of breast developing in a longstanding and recurrent
fibrocystic disease is reported. Discussion: The pathological changes including
the influence of hormones on the natural history of the disease arediscussed to identify the
determinants of malignant transformation. Conclusion: Breast cyst fluid,
patterns of cellular lining of the cysts, multiplicity, recurrence and patterns
of cellular morphology are important determinants of malignant change.
Cite this paper
Vagholkar, K. (2014) Determinants of Malignant Transformation in Fibrocystic Disease of Breast. Advances in Breast Cancer Research
, 54-58. doi: 10.4236/abcr.2014.32008
 Habo, V., Habor, A., Copotiu, C. and Pantiru, A. (2010) Fibrocystic Breast Disease—Breast Cancer Sequence. Chirurgia (Bucur), 105, 191-194.
 Vagholkar, K., Dastoor, K. and Gopinathan, I. (2013) Intracystic Papillary Carcinoma in the Male Breast: A Rare Endpoint of a Wide Spectrum. Case Reports in Oncological Medicine, 2013, Article ID: 129353.
 Dixon, J.M., Lumsden, A.B. and Miller, W.R. (1985) The relationship of Cyst Type to Risk Factors for Breast Cancer and the Subsequent Development of Breast Cancer in Patients with Breast Cystic Disease. European Journal of Cancer and Clinical Oncology, 21, 1047-1050. http://dx.doi.org/10.1016/0277-5379(85)90289-5
 Naldoni, C., Costantini, M., Dogliotti, L., Bruzzi, P., Bucchi, L., Buzzi, G., Torta, M. and Angeli, A. (1992) Association of Cyst Type with Risk Factors for Breast Cancer and Relapse Rate in Women with Gross Cystic Disease of the Breast. Cancer Research, 52, 1791-1795.
 Dixon, J.M., Scott, W.N. and Miller, W.R. (1985) Natural History of Cystic Disease: The Importance of Cyst Type. British Journal of Surgery, 72, 190-192. http://dx.doi.org/10.1002/bjs.1800720311
 Angeli, A., Dogliott, L., Naldoni, C., Orlandi, F., Puligheddu, B., Caraci, P., Bucchi, L., Torta, M. and Bruzzi, P. (1994) Steroid Biochemistry and Categorization of Breast Cyst Fluid: Relation to Breast Cancer Risk. The Journal of Steroid Biochemistry and Molecular Biology, 49, 333-339. http://dx.doi.org/10.1016/0960-0760(94)90276-3
 Budai, B., Szamel, I., Sulyok, Z., Nemeth, M., Bak, M., Kralovanszky, J., Otto, S., Besznyak, I., Purohit, A., Parish, D.C. and Reed, M.J. (2000) Influence of Hormonal Status of Patients with Cystic Disease on the Composition of Cyst Fluid and Breast Cancer Risk. Anticancer Research, 5C, 3879-3886.
 Celis, J.E., Moreira, J.M., Gromova, I., Cabezon, T., Gromov, P., Shen, T., Timmermans, V. and Rank, F. (2007) Characterization of Breast Precancerous Lesions and Myoepithelial Hyperplasia in Sclerosing Adenosis with Apocrine Metaplasia. Molecular Oncology, 1, 97-119. http://dx.doi.org/10.1016/j.molonc.2007.02.005
 Wells, C.A. and El-Ayat, G.A. (2007) Non Operative Breast Pathology: Apocrine Lesions. Journal of Clinical Pathology, 60, 1313-1320. http://dx.doi.org/10.1136/jcp.2006.040626