OJPathology  Vol.4 No.2 , April 2014
Cribriform Adenocarcinoma Salivary Gland-Type of the Nasopharynx: Case Report and Review of the Literature
Abstract: Primary salivary gland-type carcinoma of the nasopharynx is a rare malignancy with aggressive clinical behavior and poor prognosis. Few cases have been reported in the literature. We report the case of a salivary gland-type carcinoma of the nasopharynx diagnosed in a 70-year-old woman managed in department of radiotherapy at Hassan II University Hospital in Morocco. The patient received a total of 70 Gy of radiations, which were divided into 2 Gy per session during 7 weeks. Follow-up was performed regularly, including nasal endoscopic examination and nasopharyngeal CT. Evolution was marked by disease control after 12 months of follow-up. The aim of this work is to show the rarity of this entity, describe clinical, radiological and histological features and finally discuss the treatment management.
Cite this paper: Bouhafa, T. , Elmazghi, A. , Masbah, O. and Hassouni, K. (2014) Cribriform Adenocarcinoma Salivary Gland-Type of the Nasopharynx: Case Report and Review of the Literature. Open Journal of Pathology, 4, 79-82. doi: 10.4236/ojpathology.2014.42012.

[1]   Liu, T.-R., Chen, F.-J., et al. (2010) Primary Salivary Gland Type Carcinoma of the Nasopharynx: Therapeutic Outcomes and Prognostic Factors. Head & Neck, 32, 435-444.

[2]   Perzin, K.H., Gullane, P., Clairmont, A.C. (1978) Adenoid Cystic Carcinomas Arising in Salivary Glands: A Correlation of Histologic Features and Clinical Course. Cancer, 42, 265-282.<265::AID-CNCR2820420141>3.0.CO;2-Z

[3]   Papadas, T., Chorianopoulos, D. and Mastronikolis, N. (2007) Nasopharyngeal Adenoid Cystic Carcinoma: A Rare Nasopharyngeal Tumor. European Review for Medical and Pharmacological Sciences, 11, 55-57

[4]   He, J.H., Zong, Y.S., Luo, R.Z., Liang, X.M., Wu, Q.L. and Liang, Y.J. (2003) Clinicopathological Characteristics of Primary Nasopharyngeal Adenocarcinoma. Chinese Journal of Cancer, 22, 753-757.

[5]   Edge, S.B., Byrd, D.R., Compton, C.C., Fritz, A.G., Greene, F.L. and Trotti III., A. (2010) Pharynx: In AJCC Cancer Staging Manual. 7th Edition, Springer, New York, 41-56.

[6]   Glicksman, J.T., et al. (2013) An Endonasal Approach to the Resection of a Papillary Seromucinous Adenocarcinoma of the Eustacian Tube. Journal of Otolaryngology—Head and Neck Surgery, 42, 12.

[7]   Saadi, I., El Marfany, M., Hadadi, K., Amaoui, B., Kebdani, T., Errihani, H., et al. (2003) Adenoid Cystic Carcinoma of the Nasopharynx: A Case Report. Cancer Radiothérapie, 7, 190-194.

[8]   Neville, B.W., Damm, D.D., Allen, C.M. and Bouquot, J.F. (2002) Oral & Maxillofacial Pathology. W.B. Saunders Co., Philadelphia, 389-496.

[9]   Carrasco, O.D. and Aldape B.B. (2006) Adenoid Cystic Carcinoma of the Dorsum of the Tongue: Presentation of a Case. Medicina Oral, Patología Oral y Cirugía Bucal, 11, E417-E420.

[10]   Spiro, R.H., Huvos, A.G. and Strong, E.W. (1979) Adenoid Cystic Carcinoma: Factors Influencing Survival. American Journal of Surgery, 138, 579-583.

[11]   Spiro, R.H. (1997) Distant Metastasis in Adenoid Cystic Carcinoma of Salivary Origin. American Journal of Surgery, 175, 495-498.

[12]   Nuti, C., Durand, M., Duthel, R., Seguin, P., Prades, J.M., Mosnier, J.F., et al. (1997) Les carcinomes adénoïdes kystiques du sinus maxillaire à développement intracranien: Revue de la littérature, à propos d’un cas. Neurochirurgie, 43, 314-318.

[13]   Gormley, B.W., Sekhar, L.N., Wright, D.C., Olding, M., Janecka, I.P. and Richardson, R. (1996) Management and Long-Term Outcome of Adenoid Cystic Carcinoma with Intracranial Extension: A Neurosurgical Perspective. Neuro-surgery, 38, 1105-1112

[14]   Liu, T.R., Chen, F.J., Zhang, G.P. and Yang, A.K. (2011) Different Therapeutic Strategies in Primary Salivary Gland-Type Nasopharyngeal Carcinomas. Current Opinion in Otolaryngology & Head and Neck Surgery, 19, 87-91.

[15]   Lee, D.J., Smith, R.R., Spaziani, J.T., Rostock, R., Holliday, M. and Moses, H. (1985) Adenoid Cystic Carcinoma of the Nasopharynx. Case Reports and Literature Review. Annals of Otology, Rhinology, and Laryngology, 94, 269-272.

[16]   Jones, A.S., Hamilton, J.W., Rowley, H., et al. (1997) Adenoid Cystic Carcinoma of the Head and Neck. Clinical Otolaryngology & Allied Sciences, 22, 434-443.

[17]   Shotton, J.C., Schmid, S. and Fisch, U. (1991) The Infratemporal Fossa Approach for Adenoid Cystic Carcinoma of the Skull Base and Nasopharynx. Otolaryngologic Clinics of North America, 24, 1445-1464.

[18]   Wang, C.C., See, L.C., Hong, J.H. and Tang, S.G. (1996) Nasopharyngeal Adenoid Cystic Carcinoma: Five New Cases and a Literature Review. Journal of Otolaryngology, 25, 399-403.

[19]   Pitman, K.T., Prokopakis, E.P., Aydogan, B., Segas, J., Carrau, R.L., Snyderman, C.H., et al. (1999) The Role of Skull Base Surgery for the Treatment of Adenoid Cystic Carcinoma of the Sinonasal Tract. Head & Neck, 21,402-407. (SICI)1097-0347(199908)21:5<402::AID-HED4>3.0.CO;2-Z

[20]   Schramm Jr., V.L. and Imola, M.J. (2001) Management of Nasopharyngeal Salivary Gland Malignancy. Laryngoscope, 111, 1533-1544.

[21]   Sur, R.K., Donde, B., Levin, V., Pacella, J., Kotzen, J., Cooper, K., et al. (1997) Adenoid Cystic Carcinoma of the Salivary Glands: A Review of 10 Years. Laryngoscope, 107, 1276-1280. 10.1097/00005537-199709000-00022

[22]   Vikram, B., Strong, E.W., Shah, J.P. and Spiro, R.H. (1984) Radiation Therapy in Adenoid-Cystic Carcinoma. International Journal of Radiation Oncology, Biology, Physics, 10, 221-223.

[23]   Alleyne, C.H., Bakay, R.A., Costigan, D., Thomas, B. and Joseph, G.J. (1996) Intracranial Adenoid Cystic Carcinoma: Case Report and Review of the Literature. Surgical Neurology, 45, 265-270. 10.1016/0090-3019(95)00235-9

[24]   Cao, C.N., Luo, J.W., Xu, G.Z., Gao, L., Xu, Z.G. and Tang, P.Z. (2013) Management of Nasopharyngeal Adenoid Cystic Carcinoma. Journal of Oral and Maxillofacial Surgery, 71, e203-e209.