OJOG  Vol.4 No.6 , April 2014
FRIOS Parameters, Key to Reduce Feto-Maternal Mortality in Pre-Eclampsia
ABSTRACT

Objective(s): To evaluate the role of free radical induced oxidative stress in predicting, prevent and prompt management of pre-eclampsia. Method(s): This prospective study was conducted on 320 pregnant women of which 240 women with pregnancy induced hypertension taken as study group and 80 normal pregnant women were taken as control. Free radical status was evaluated by estimating lipid peroxidation product malonyladehyde and antioxidants-superoxide dismutase, catalase, glutathione reductase. Statistical analysis was done by using SPSS software. Result(s): Pre-eclampsia is significantly associated with free radical induced oxidative stress. Serum level of lipid peroxidation product malondialdehyde increased in pre-eclamptic women. Serum level of antioxidants SuperOxide Dismutase, Catalase level, Glutathione Reductase were reduced. Results are statistically significant. Conclusion(s): Free radical induced oxidative stress is increasing in pre-eclampsia and plays a critical role in etiopathogenesis of pre-eclampsia.


Cite this paper
Sharma, A. , Tiwari, A. , Kiran, P. and Meera, A. (2014) FRIOS Parameters, Key to Reduce Feto-Maternal Mortality in Pre-Eclampsia. Open Journal of Obstetrics and Gynecology, 4, 321-325. doi: 10.4236/ojog.2014.46048.
References
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[3]   Mac Donald-Wicks, L.K. and Garg, M.L. (2002) Modulation of Carbon Tetrachloride-Induced Oxidative Stress by Dietary Fat in Rats. The Journal of Nutritional Biochemistry, 13, 87-95.
http://dx.doi.org/10.1016/S0955-2863(01)00199-1

[4]   Serdar, Z., Gur, E., Develioglu, O., Colakogullari, M. and Dirican, M. (2002) Placental and Decidual Lipid Peroxidation and Antioxidant Defenses in Pre-Eclampsia. Lipid Peroxidation in Pre-Eclampsia. Pathophysiology, 9, 21-25. http://dx.doi.org/10.1016/S0928-4680(02)00052-4

[5]   Noyan, T., Tahin, I., Sekeroglu, M.R. and Dulger, H. (2003) The Serum Vitamin C Levels in Behcet’s Disease. Yonsei Medical Journal, 44, 771-778.

[6]   Bowen, R.S., Moodley, J., Dutton, M.F. and Theron, A.J. (2001) Oxidative Stress in Pre-Eclampsia. Acta Obstetricia et Gynecologica Scandinavica―Wiley Online Library, 80, 719-725.
http://dx.doi.org/10.1034/j.1600-0412.2001.080008719.x

[7]   Gitto, E., Retter, R.J., Karbownik, M., et al. (2002) Causes of Oxidative Stress in the Preand Perinataln Period. Biological Neonate, 81, 146-157. http://dx.doi.org/10.1159/000051527

[8]   Harsem, N.K., Braekke, K. and Staff, A.C. (2005) Augmented Oxidative Stress as Well as Antioxidant Capacity in Maternal Circulation in Pre-Eclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology, 45, 456-467.

[9]   Tastekin, A., Ors, R., Demircan, B., Saricam, Z., Ingec, M. and Akcay, F. (2005) Oxidative Stress in Infants Born in Pre-Eclamptic Mothers. Pediatrics International, 47, 658-662.
http://dx.doi.org/10.1111/j.1442-200x.2005.02146.x

[10]   Kumar, C.A. and Das, U.N. (2000) Lipid Peroxides, Antioxidants and Nitric Oxide in Patients with Preeclampsia and Essential Hypertention. Medical Science Monitor, 6, 901-907.

[11]   Madazli, R., Benian, A., Aydin, S., Uzun, H. and Tolun, N. (2002) The Plasma and Placental Levels of Malondialdehyde, Glutathione and Superoxide Dismutase in Pre-Eclampsia. Journal of Obstetrics & Gynaecology, 22, 477-480. http://dx.doi.org/10.1080/0144361021000003573

[12]   Sharma, J.B., Sharma, A., Bahadur, A., Vimala, N., Satyam, A. and Mittal, S. (2006) Oxidative Stress Markers and Antioxidant Levels in Normal Pregnancy and Pre-Eclampsia. International Journal of Gynecology & Obstetrics, 94, 23-27. http://dx.doi.org/10.1016/j.ijgo.2006.03.025

[13]   Chamy, V.M., Lepe, J., Catalán, A., Retamal, D., Escobar, J.A. and Madrid, E.M. (2006) Oxidative Stress Is Closely Related to Clinical Severity of Pre-Eclampsia. Biological Research, 39, 229-236. http://dx.doi.org/10.4067/S0716-97602006000200005

[14]   Patil, S.B., Kodliwadmath, M.V. and Kodliwadmath, M. (2009) Lipid Peroxidation and Antioxidant Activity in Complicated Pregnancies. Clinical and Experimental Obstetrics and Gynecology, 36, 110-112.

[15]   Berg, C.J., Atrash, H.K., Koonin, L.M. and Tucker, M. (1996) Pregnancy Related Mor Detection of Significant Proteinurea in Pregnant Women with Suspected Preeclampsiatality in the United State (1987-1990). Journal of Obstetrics & Gynaecology, 88, 161-165. http://dx.doi.org/10.1016/0029-7844(96)00135-4

[16]   Perkins, A.V. (2006) Endogenous Antioxidants in Pregnancy and Preeclampsia. Australian and New Zealand Journal of Obstetrics and Gynaecology, 46, 77-83. http://dx.doi.org/10.1111/j.1479-828X. 2006.00532.x

[17]   Mac Donald-Wicks, L.K. and Garg, M.L. (2002) Modulation of Carbon Tetrachloride-Induced Oxidative Stress by Dietary Fat in Rats. The Journal of Nutritional Biochemistry, 13, 87-95.
http://dx.doi.org/10.1016/S0955-2863(01)00199-1

[18]   Serdar, Z., Gur, E., Develioglu, O., Colakogullari, M. and Dirican, M. (2002) Placental and Decidual Lipid Peroxidation and Antioxidant Defenses in Pre-Eclampsia. Lipid Peroxidation in Pre-Eclampsia. Pathophysiology, 9, 21-25. http://dx.doi.org/10.1016/S0928-4680(02)00052-4

[19]   Noyan, T., Tahin, I., Sekeroglu, M.R. and Dulger, H. (2003) The Serum Vitamin C Levels in Behcet’s Disease. Yonsei Medical Journal, 44, 771-778.

[20]   Bowen, R.S., Moodley, J., Dutton, M.F. and Theron, A.J. (2001) Oxidative Stress in Pre-Eclampsia. Acta Obstetricia et Gynecologica Scandinavica―Wiley Online Library, 80, 719-725.
http://dx.doi.org/10.1034/j.1600-0412.2001.080008719.x

[21]   Gitto, E., Retter, R.J., Karbownik, M., et al. (2002) Causes of Oxidative Stress in the Preand Perinataln Period. Biological Neonate, 81, 146-157. http://dx.doi.org/10.1159/000051527

[22]   Harsem, N.K., Braekke, K. and Staff, A.C. (2005) Augmented Oxidative Stress as Well as Antioxidant Capacity in Maternal Circulation in Pre-Eclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology, 45, 456-467.

[23]   Tastekin, A., Ors, R., Demircan, B., Saricam, Z., Ingec, M. and Akcay, F. (2005) Oxidative Stress in Infants Born in Pre-Eclamptic Mothers. Pediatrics International, 47, 658-662.
http://dx.doi.org/10.1111/j.1442-200x.2005.02146.x

[24]   Kumar, C.A. and Das, U.N. (2000) Lipid Peroxides, Antioxidants and Nitric Oxide in Patients with Preeclampsia and Essential Hypertention. Medical Science Monitor, 6, 901-907.

[25]   Madazli, R., Benian, A., Aydin, S., Uzun, H. and Tolun, N. (2002) The Plasma and Placental Levels of Malondialdehyde, Glutathione and Superoxide Dismutase in Pre-Eclampsia. Journal of Obstetrics & Gynaecology, 22, 477-480. http://dx.doi.org/10.1080/0144361021000003573

[26]   Sharma, J.B., Sharma, A., Bahadur, A., Vimala, N., Satyam, A. and Mittal, S. (2006) Oxidative Stress Markers and Antioxidant Levels in Normal Pregnancy and Pre-Eclampsia. International Journal of Gynecology & Obstetrics, 94, 23-27. http://dx.doi.org/10.1016/j.ijgo.2006.03.025

[27]   Chamy, V.M., Lepe, J., Catalán, A., Retamal, D., Escobar, J.A. and Madrid, E.M. (2006) Oxidative Stress Is Closely Related to Clinical Severity of Pre-Eclampsia. Biological Research, 39, 229-236.
http://dx.doi.org/10.4067/S0716-97602006000200005

[28]   Patil, S.B., Kodliwadmath, M.V. and Kodliwadmath, M. (2009) Lipid Peroxidation and Antioxidant Activity in Complicated Pregnancies. Clinical and Experimental Obstetrics and Gynecology, 36, 110-112.

 
 
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