Department of Biology, Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia. Department of Biology, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.
Objectives: The aim of the investigation was to study the hormonal status (sex hormones: estradiol (E2), progesterone (P), testosterone (T); non-sex gonadotropic hormones-luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) of women with benign and malignant tumors of uterine body in the reproductive, menopause and postmenopause periods. Also the distribution features of the blood ABO system phenotype groups and their link to the development of uterine body tumors have been studied. Methods: The determination of hormones was made by the enzyme analysis method (ELAIZA), provided by the proper ELAIZA kits. For the study of blood ABO system antigens, internationally recognized immunoserology methods were used. Results: Investigations revealed the increased level of E2 and T on the background of the reduced P in the blood of the women with uterine tumors in the reproductive, menopause and post-menopause period. As for gonadotropic hormones, the decreased levels of LH and FSH have also been detected. From the ABO system phenotype groups A(II) group had the highest frequency between the women with malignant uterine tumor in the reproductive age. O (I) phenotype group was the most frequent in case of menopause and post-menopause women with uterine malignant tumors. Conclusions: Hormonal imbalance creates good conditions for the proliferation of uterine tissues and hence causes the development of benign and malignant uterine tumors. The imbalance of the sex steroid and gonadotropic hormones in the blood of post-menopause women indicates on the genotoxic mechanism of cancer development on the background of age-related changes. A(II) group had the highest frequency between the reproductive age women with uterine malignant tumor, while O (I) group was the most frequent in case of menopause and post-menopause patients.
Nakashidze, I. , Diasamidze, A. , Baratashvili, D. , Nagervadze, M. , Alibegashvili, M. , Ramishvili, L. , Gordeziani, M. , Khazaradze, A. and Kotrikadze, N. (2014) Alteration of Sex and Non-Sex Hormones and Distribution Features of Blood ABO System Groups among the Women with Uterine Body Tumors. Journal of Cancer Therapy, 5, 411-419. doi: 10.4236/jct.2014.55047.
[1] Menasce, L.P., White, G.R., Harrison, C.J. and Boyle, J.M. (1993) Localization of the Estrogen Receptor Locus (ESR) to Chromosome 6q25.1 by FISH and a Simple Post-FISH Banding Technique. Journal of Genomics, 17, 263-265. http://dx.doi.org/10.1006/geno.1993.1320 [2] Bender, D., Thomas, B. and Leslie, K. (2011) Hormones and Receptors in Endometrial Cancer. Proceedings in Obstetrics and Gynecology, 2, 1-25. [3] Bershtein, L.M. (2000) Hormonal Carcinogenesis. SPB. Nauka. 64-73. [4] Henderson, B.E. and Feigelson, H.S. (2000) Hormonal Carcinogenesis. Carcinogenesis, 21, 427-433. http://dx.doi.org/10.1093/carcin/21.3.427 [5] Ovsyanikova, T.V., Speranskaya, N.V., et al. (2000) Androgens in Physiology and Patho-Physiology of Women’s Organism. Gynecology, 2, 2. [6] Laycock, F.J. and Wise, H.P. (1996) Essential Endocrinology. Oxford University Press, Oxford.
http://trove.nla.gov.au/work/11667680 [7] Hale, G.E., Hughes, C.L. and Cline, J.M. (2002) Endometrial Cancer: Hormonal Factors, the Perimenopausal “Window of Risk,” and Isoflavones. Journal of Clinical Endocrinology and Metabolism, 87, 3-15. [8] Stamatakos, M., Kontzoglou, K., Safioles, P., Safioles, C., Manti, C. and Safioles, M. (2009) Breast Cancer Incidence in Greek Women in Relation to ABO Blood Groups and Rh Factor. Journal of International Seminars in Surgical Oncology, 16, 1-15. [9] Adamian, R.T. (2005) Blood Type and Rhesus Distribution in Armenian Women with Endometrial Carcinoma. Voprosy Onkologii, 51, 575-576. [10] Wolpin, M.B., Chain, A.T., Hartge, P., Stephen, C., Kraft, J.P., Hunter, D.H., et al. (2009) ABO Blood Groups and the Risk of Pancreatic Cancer. Journal of National Cancer Institute, 10, 424-431. http://dx.doi.org/10.1093/jnci/djp020 [11] Garrety, G. (2005) Do We Need to Be More Concerned about Weak D Antigens? Journal of Transfusion, 45, 1547-1551. http://dx.doi.org/10.1111/j.1537-2995.2005.00625.x [12] Jovanovic-Cupic, S., Stamencovic, G., Blagojevic, J., Vanis, N., Stanojevic, B. and Berberovic, L.J. (2008) ABO Histo-Blood Groups and Rh Systems in Relation to Malignant Tumors of the Digestive Tract in Bosnia and Herzegovenia. Journal of Archives of Biological Sciences, 60, 593-599. http://dx.doi.org/10.2298/ABS0804593J [13] Amundadottir, L., Kraft, P., Stolzenberg-Solomon, R.Z., Fuchs, C.S., Petersen, G.M., Arslan, A.A., et al. (2009) Genome-Wide Association Study Identifies Variants in the ABO Locus Associated with Susceptibility to Pancreatic Cancer. Journal of Nature Genetics, 41, 986-990.
http://dx.doi.org/10.1038/ng.429 [14] Bayan, K., Tuzun, Y., Yilmaz, S., Dursun, M. and Canoruc, F. (2009) Clarifying the Relationship between ABO/Rhesus Blood Group Antigens Upper and Gastrointestinal Bleeding. Journal of Digestive Diseases and Sciences, 54, 1029-1034. http://dx.doi.org/10.1007/s10620-008-0446-0 [15] Anestee, D.J. (2010) The Relationship between Blood Groups And Disease. Journal of Blood, 15, 4635-4643. http://dx.doi.org/10.1182/blood-2010-01-261859 [16] Edgren, G., Hjalgrim, H., Rostgaard, K., Norda, R., Wikman, A., et al. (2010) Risk of Gastric Cancer and Peptic Ulcers in Relation to ABO Blood Type: A Cohort Study. American Journal of Epidemiology, 172, 1280-1285. http://dx.doi.org/10.1093/aje/kwq299 [17] Greer, J.B., Yazer, M.H., Raval, J.S., Barmada, M.M., Brand, R.E. and Whitcomb, D.C. (2010) Significant Association between ABO Blood Group and Pancreatic Cancer. World Journal of Gastroenterol, 16, 5588-5591. http://dx.doi.org/10.3748/wjg.v16.i44.5588 [18] Qiu, M.Z., Zhang, D.S., Ruan, D.Y., Luo, H.Y., Wang, Z., et al. (2010) A Relationship Between ABO Blood Groups and Clinicopathologic Characteristics of Patients with Gastric Adenocarcinoma in China. Journal of Medical Oncology, 28, S268-S273. http://dx.doi.org/10.1007/s12032-010-9735-5 [19] Gates, M.A., Xu, M., Chen, W.Y., Kraft, P., Hankinson, S.E. and Wolpin, B.M. (2012) ABO Blood Group and Breast Cancer Incidence and Survival. International Journal of Cancer, 130, 2129-2137. http://dx.doi.org/10.1002/ijc.26220 [20] Tupinashvili, T. (2006) The Study of Blood Lipid and Protein Spectrum in Case of Hormonal Imbalance during Uterine Body Tumors. Ph.D. Dissertation, Ivane Javakhishvili Tbilisi State University, Tbilisi. [21] Costantini, M., Fassio, T., Canobbioet, L., Landucci, M., Resasco, M. and Boccardo, F. (1990) Role of Blood Groups as Prognostic Factors in Primary Breast Cancer. Journal of Oncology, 47, 308-312. http://dx.doi.org/10.1159/000226839