CRCM  Vol.3 No.4 , April 2014
Severe Isolated Thrombocytopenia Associated with the Use of Clopidogrel
ABSTRACT

Clopidogrel is used as a frontline antiplatelet drug in patients with coronary artery disease, peripheral vascular disease and cerebrovascular disease. Though it is frequently reported that clopidogrel is associated with thrombotic thrombocytopenic purpura (TTP), severe isolated thrombocytopenia induced by this drug is rare. Here we report a case with isolated thrombocytopenia due to clopidogrel therapy. As this agent is widely used in clinical practice, the occurrence of this rare but dangerous adverse effect should be considered.


Cite this paper
Zhang, Y. , Zhou, H. and Han, W. (2014) Severe Isolated Thrombocytopenia Associated with the Use of Clopidogrel. Case Reports in Clinical Medicine, 3, 244-248. doi: 10.4236/crcm.2014.34056.
References
[1]   Balamuthusamy, S. and Arora, R. (2007) Hematologic Adverse Effects of Clopidogrel. American Journal of Therapeutics, 14, 106-112.
http://dx.doi.org/10.1097/01.mjt.0000212708.81034.22

[2]   Su, C.H., Tsai, C.F., Ueng, K.C., et al. (2004) Clopidogrel-Associated Severe Isolated Thrombocytopenia—A Case Report. Acta Cardiological Sinica, 20, 182-186.

[3]   Elmi, F., Peacock, T. and Schiavone, J. (2000) Isolated Profound Thrombocytopenia Associated with Clopidogrel. Journal of Invasive Cardiology, 12, 532-535.

[4]   Helft, G., Elalamy, I., Laudy, C., et al. (2003) Clopidogrel and Thrombopenia. A Case Report. Annales de Cardiologie et d’Angéiologie, 52, 191-193.
http://dx.doi.org/10.1016/S0003-3928(02)00185-3

[5]   da Silva Vedes, E.C., Marques, L.D.G. and Rico, M.C.T. (2011) Severe Isolated Thrombocytopenia after Clopidogrel and Pentoxifylline Therapy: A Case Report. Journal of Medical Case Reports, 5, 281.
http://dx.doi.org/10.1186/1752-1947-5-281

[6]   Drachman, J.G. (2004) Inherited Thrombocytopenia: When a Low Platelet Count Does Not Mean ITP. Blood, 103, 390-398.
http://dx.doi.org/10.1182/blood-2003-05-1742

[7]   George, J.N. and Aster, R.H. (2009) Drug-Induced Thrombocytopenia: Pathogenesis, Evaluation, and Management. Hematology American Society of Hematology Education Program, 2009, 153-158.
http://dx.doi.org/10.1182/asheducation-2009.1.153

[8]   Scirica, B.M., Cannon, C.P., Cooper, R., et al. (2006) Drug-Induced Thrombocytopenia and Thrombosis: Evidence from Patients Receiving an Oral Glycoprotein IIb/IIIa Inhibitor in the Orbofiban in Patients with Unstable Coronary Syndromes-(OPUS-TIMI 16) Trial. Journal of Thrombosis and Thrombolysis, 22, 95-102.

 
 
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