JCPT  Vol.4 No.2 , April 2014
Reaction Rate Models for the Thermal Decomposition of Ibuprofen Crystals
ABSTRACT
Kinetics of the decomposition of racemic ibuprofen crystals were studied by non-isothermal analysis. Thermogravimetric analysis revealed that ibuprofen is thermally stable up to 152.6°C and the initial loss of mass was due to evaporation only. Activation energy, pre-exponential factor, activation entropy and Gibbs free energy for the decomposition of ibuprofen were determined using the integral method of Coats-Redfern (CR). Geometrical contraction models were found to be the best fits. The Arrheinus equation for the thermal decomposition of ibuprofen is k = (1.1 × 107) e–79125/RT sec–1.

Cite this paper
Ramukutty, S. and Ramachandran, E. (2014) Reaction Rate Models for the Thermal Decomposition of Ibuprofen Crystals. Journal of Crystallization Process and Technology, 4, 71-78. doi: 10.4236/jcpt.2014.42010.
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