Effect of Salacca Vinegar Var. Suwaru on Lipid Profile Diabetic Rats

Elok  Zubaidah; Desta Yossy  Ichromasari; Oty Kiki  Mandasari

doi:10.4236/fns.2014.59084

Elok Zubaidah, Desta Yossy Ichromasari, Oty Kiki Mandasari

Abstract: Diabetes mellitus is a group of metabolic diseases with hyperglycemia characteristic that occurs because of abnormalities of insulin secretion. And it becomes one of the major degenerative diseases in the world. The number of studies is conducted to produce hypoglycemic compound and hipolipidemia as an alternative to chemical drugs. One of natural product is salacca vinegar. The purpose of this research is to determine the effect of Salacca vinegar var. Suwaru impact on the diabetic lipid profile of male rats that induced by STZ (Streptozotocin). This reseacrh is conducted by Experimental Post Test Randomized Control Design. Under this research, involves 4 groups, spesifically normal group, diabetic group, diabetic + salacca vinegar 0.4 cc, diabetic + salacca vinegar 0.7 cc. The data were analyzed by ANOVA (Analysis of Variance). The means were assessed for differences through Least Significant Difference (LSD) 0.05. The results showed that Salacca vinegar var. Suwaru with a dose of 0.4 cc/rat/day and 0.7 cc/rat/day influence on lipid profile levels of diabetic rats which affect on decreasing LDL, Trygliceride, total cholesterol and increasing HDL serum plasma diabetic rats.

Keywords: Salacca Vinegar; Diabetic Rats; Dyslipidemia

Cite this paper: Zubaidah, E. , Ichromasari, D. and Mandasari, O. (2014) Effect of Salacca Vinegar Var. Suwaru on Lipid Profile Diabetic Rats. Food and Nutrition Sciences, 5, 734-748. doi: 10.4236/fns.2014.59084.

References

[1] Shishehbor, F., Mansoori, A., Sarkaki, A.R., Jalali, M.T. and Latifi, S.M. (2008) Apple Cider Salacca Vinegar Attenuates Lipid Profile in Normal and Diabetic Rats. Pakistan Journal of Biological Sciences, 11, 2634-2638.
http://dx.doi.org/10.3923/pjbs.2008.2634.2638

[2] Hernawan, U., Sutarno, E. and Setyawan, A.D. (2004) Hypoglycemic and Hypolipidemic Activity Leaves Water Extract Lagerstroemia (Lagerstroemia speciosa [L.] Pers.) on Diabetic Rats. J. Biopharmaceutical, 2, 15-23.

[3] Johston, C.S. and Gass, C.A. (2006) Salacca Vinegar: Medicinal Uses and Antiglysemic Effect. Medscape General Medicine, 8, 61.

[4] Fushimi, T., Suruga, K., Oshima, Y., Momoko, M., Tsukamoto, Y. and Goda, T. (2006) Dietary Acetic Acid Reduces Serum Cholesterol and Triacylglycerols in Rats Fed a Cholesterol-Rich Diet. British Journal of Nutrition, 95, 916-924.
http://dx.doi.org/10.1079/BJN20061740

[5] Leeds, A.R. (2002) Glycemic Index and Heart Diseases. The American Journal of Clinical Nutrition, 76, 286-289.

[6] Slyper, A., Jurva, J., Pleuss, J., Hoffmann, R. and Gutterman, D. (2004) Influence of Glycemic Load on HDL Cholesterol in Youth. The American Journal of Clinical Nutrition, 81, 376-379.

[7] Zubaidah, E. and Kurniawan, Y. (2011) The Influence of the Type of Fruit (Salak and Apples) and Concentration Yeast Bread (Instant Dry Yeast) Antioxidant and Antibacterial Activity against Vinegar Salak (Salacca zalacca) and Vinegar Apples (Malus sylvestris). Journal of Agricultural Technology, 14.

[8] Leontowics, H., Leontowicz, M., Drzewiecki, J., Jastrzebski, Z., Haruenkit, R., Poovarodom, S., Park, Y.S., Jung, S.T., Kang, S.G., Trakhtenberg, S. and Gorinstein, S. (2007) Two Exotic Fruits Positively Affect Rat’s Plasma Composition. Food Chemistry, 102, 192-200.
http://dx.doi.org/10.1016/j.foodchem.2006.05.046

[9] Ostman, E., Granfeldt, E.Y., Persson, L. and Bjorok, I. (2005) Salacca Vinegar Supplementation Lowers Glucose and Insulin Responses and Increases Satiety after a Bread Meal in Healthy Subjects. European Journal of Clinical Nutrition, 59, 983-988. http://dx.doi.org/10.1038/sj.ejcn.1602197

[10] Nagasako-Akazome, Y., Kanda, T., Ohtake, Y., Shimasaki, H. and Kobayashi, T. (2007) Apple Polyphenols Influence Cholesterol Metabolism in Healthy Subjects with Relatively High Body Mass Index. Journal of Oleo Science, 56, 416-428. http://dx.doi.org/10.5650/jos.56.417

[11] Vidal, R., Hernandez-Vallejo, S. and Pauquai, T. (2005) Apple Procyanidins Decrease Cholesterol Esterification and Lipoprotein Secretion in Caco-2/TC7 Enterocytes. The Journal of Lipid Research, 46, 258-268.
http://dx.doi.org/10.1194/jlr.M400209-JLR200

[12] Huda, M.S. (2006) Inside Cholesterol. http://www.kafka.web.id

[13] Faradilla, R.H.F. (2010) Profile and Lipid Peroxidation Rat Experiment after Giving Peanut Flour Tempe Komak (Lablab purpureus (L.) Sweet). Thesis, Bogor Agricultural University, Bogor.

[14] Howard, B.V. (1987) Lipoprotein Metabolism in Diabetes Mellitus. The Journal of Lipid Research, 28, 613-628.

[15] Mayes, P.A. (1997) Lipid Transport and Storage. In: Murry, R.K., Granner, D.K., Mayes, P.A. and Rodwell, V.W., Eds., A. Hartono (Translators), Harper’s Biochemistry, 24th Edition, EGC Book Medical Publishers, Jakarta.

[16] Mahan, L.K. and Stump, S.E. (2004) Krause’s Food, Nutrition, & Diet Therapy. 9th Edition, Elsevier, Amsterdam.

[17] Friedewald, W.T., Levy, R.I. and Frederickson, D.S. (1972) Estimation of the Concentration Low-Density Lipoprotein Cholesterol in Plasma without Use the Preparative Ultracentrifuge. Clinical Chemistry, 18, 499-502.