hemangioendothelioma is a rare, recently described neoplasm that
usually presents as multifocal lesions in a single extremity. The disease has
demonstrated a high propensity for infiltrative growth and local recurrence but
limited metastatic potential. Variations of histological appearance and
immunohistochemical signatures have been described, but typically involve
spindle or polygonal cells with nuclear atypia and neutrophilic infiltration.
Here we present a case report of an 8-year-old female who presented with hip
pain that was initially diagnosed and managed as a slipped capital femoral
epiphysis (SCFE). Subsequent evaluation led to the diagnosis of pseudomyogenic
hemangioendothelioma of bone. Due to the degree of osseous destruction,
described patterns of local recurrence, and metastatic potential of this
neoplasm, a wide resection with endoprosthetic reconstruction of the proximal
femur was performed. This case highlights the importance of due diligence in
the diagnoses of SCFE and bone tumors in young patients with abnormalities of
the proximal femur, including consideration of the need for biopsy.
Cite this paper
Friel, N. , Rothenberg, A. and Weiss, K. (2014) Pseudomyogenic Hemangioendothelioma of Bone Initially Managed as Slipped Capital Femoral Epiphysis: A Case Report. Journal of Cancer Therapy
, 363-368. doi: 10.4236/jct.2014.54043
 Billings, S.D., Folpe, A.L. and Weiss, S.W. (2003) Epithelioid Sarcoma-Like Hemangioendothelioma. The American Journal of Surgical Pathology, 27, 48-57. http://dx.doi.org/10.1097/00000478-2003 01000-00006
 Hornick, J.L. and Fletcher, C.D. (2011) Pseudomyogenic Hemangioendothelioma: A Distinctive, Often Multicentric Tumor with Indolent Behavior. The American Journal of Surgical Pathology, 35, 190-201.
 Mirra, J.M., Kessler, S., Bhuta, S. and Eckardt, J. (1992) The Fibroma-Like Variant of Epithelioid Sarcoma. A Fibrohistiocytic/Myoid Cell Lesion Often Confused with Benign and Malignant Spindle Cell Tumors. Cancer, 69, 1382-1395. http://dx.doi.org/10.1002/1097-0142(19920315)69:6<1382::AID-CNCR2820690614>3.0.CO;2-Y
 Jo, V.Y. and Fletcher, C.D. (2014) WHO Classification of Soft Tissue Tumours: An Update Based on the 2013 (4th) Edition. Pathology, 46, 95-104. http://dx.doi.org/10.1097/PAT.0000000000000050
 Cacciatore, M. and Dei Tos, A.P. (2014) Challenging Epithelioid Mesenchymal Neoplasms: Mimics and Traps. Pathology, 46, 126-134. http://dx.doi.org/10.1097/PAT.0000000000000063
 Mangham, D.C. and Kindblom, L.G. (2014) Rarely Metastasizing Soft Tissue Tumours. Histopathology, 64, 88-100.
 Sheng, W., Pan, Y. and Wang, J. (2013) Pseudomyogenic Hemangioendothelioma: Report of an Additional Case with Aggressive Clinical Course. The American Journal of Dermatopathology, 35, 597-600.
 Sheng, W.Q. and Wang, J. (2012) Primary Pseudomyogenic Haemangioendothelioma of Bone. Histopathology, 61, 1219-1224. http://dx.doi.org/10.1111/j.1365-2559.2012.04347.x
 Trombetta, D., Magnusson, L., von Steyern, F.V., Hornick, J.L., Fletcher, C.D. and Mertens, F. (2011) Translocation t(7;19) (q22;q13)-A Recurrent Chromosome Aberration in Pseudomyogenic Hemangioendothelioma? Cancer Genetics, 204, 211-215. http://dx.doi.org/10.1016/j.cancergen. 2011.01.002