IJOHNS  Vol.3 No.2 , March 2014
Is Meniere Disease Caused by a Pathological Immune Response?

The etiology of Meniere disease (MD) is unknown. Among the several factors which can provoke the disease is a pathological immune response. Objective: To investigate whether MD is due to a pathological immune reaction. Materials and methods: Immunological assay (IA) was evaluated in a consecutive study on 159 patients with MD (mean age 47.8. years) and the results compared with those from 26 patients operated on because of vestibular schwannoma (VS, mean age 54.1 years), who served as a control group. In cases of MD, transtympanic electrocochleography (ECoG) and hearing threshold were measured. Results: The average hearing level (HL) in the affected ears of patients with MD was 30 dB. Evidence of abnormal plasma protein pattern was found in 127 MD patients (80%). Elevations were found in β1-globulin (54.5%), β2-globulin (26.5%), a2-globulin (34.3%), g-globulin (17.3%), complement (CH100, 36.4%) and antinuclear antibodies (ANA, 43.4%). The onset of the disease did not correlate with the level of the plasma protein neither with the level of IgG titers. Conclusion: Elevated certain plasma proteins in patients with Meniere’s disease could be a sign that Meniere’s disease is a consequence of pathological immune reaction.

Cite this paper: Selmani, Z. , Pyykkö, I. and Ashammakhi, N. (2014) Is Meniere Disease Caused by a Pathological Immune Response?. International Journal of Otolaryngology and Head & Neck Surgery, 3, 106-112. doi: 10.4236/ijohns.2014.32021.

[1]   Derebery, M.J., Rao, V.S., Siglock, T.J., Linthicum, F.H. and Nelson, R.A. (1991) Menière’s Disease. An Immune Complex-Mediated Illness? Laryngoscope, 101, 225-229.

[2]   McCabe, B.F. (1979) Autoimmune Sensorineural Hearing Loss. Annals of Otology, Rhinology, and Laryngology, 88, 585-589.

[3]   Harris, J.P. (1983) Immunology of the Inner Ear. Otolaryngology, Head and Neck Surgery, 91, 17-23.

[4]   (1995) Committee on Hearing and Equilibrium Guidelines for the Diagnosis and Evaluation of Therapy in Ménierè’s Disease. American Academy of Otolaryngology—Head and Neck Foundation, Inc. Otolaryngology—Head and Neck Surgery, 113, 181-185.

[5]   Meri, S. (1987) Complement Activation. Demonstration of C3 Conversion and Detection of Complement Activators. Thesis. University of Helsinki, Helsinki.

[6]   Tan, E.M. (1982) Antibodies to Nuclear Antigens (ANA): Their Immunology and Medicine. Advances in Immunology, 33, 167-240.

[7]   Cabau, N. and Badin, J. (1965) Dosage spécifique de l’antistreptolysine o élimination des inhibiteurs non-spécifiques de la streptolysine o par l’heparine en présence de calcium. Clinica Chimica Acta, 12, 508-514.

[8]   Petz, L.D. (1986) Autoimmune and Drug-Induced Immune Hemolytic Anemia. In: Rose, N.R., Friedman, H. and Fahey, J.L., Manual of Clinical Laboratory Immunology, American Society for Microbiology, Washington DC, 613-629.

[9]   Selmani, Z., Pyykkö, I., Ishizaki, H. and Ashammakhi, N. (2002) Use of Electrocochleography in Assessing Endolymphatic Hydrops in Patients with Lyme Disease and Meniere Disease. Acta Oto-Laryngologica (Stockholm, Sweden), 122, 173-178.

[10]   Moscicki, R.A., San Martin, J.E., Quintero, C.H., Rauch, S.D., Nadol Jr., J.B. and Bloch, K.J. (1994) Serum Antibody to Inner Ear Proteins in Patients with Progressive Hearing Loss. Correlation with Disease Activity and Response to Corticosteroid Treatment. The Journal of the American Medical Association, 272, 611-616.

[11]   Gottschlich, S., Billings, P.B., Keithley, E.M., Weisman, M.H. and Harris, J.P. (1995) Assessment of Serum Antibodies in Patients with Rapidly Progressive Sensorineural Hearing Loss and Meniere Disease. Laryngoscope, 105, 1347-1352.

[12]   Harris, J.P. and Aframian, D. (1994) Role of Autoimmunity in Contralateral Delayed Endolymphatic Hydrops. American Journal of Otolaryngology. 15, 710-716.

[13]   Derebery, M.J., Rao, V.S., Siglock, T.J., Linthicum, F.H. and Nelson, R.A. (1991) Meniere’s Disease; an Immune Complex-Mediated Illness? Laryngoscope, 101, 225-229.

[14]   Brookes, G.B., Morrison, A.W. and Richard, R. (1985) Unilateral Meniere’s Disease: Is the the Contralateral Ear Normal? American Journal on Otolaryngology, 6, 495-499.

[15]   Dornhoffer, J.L., Waner, M., Arenberg, I.K. and Montague, D. (1993) Immunoperoxidase Study of the Endolymphatic Sac in Meniere Disease. Laryngoscope, 103, 1027-1034.

[16]   Savastano, M., Giacomelli, L. and Marioni, G. (2007) Non-Specific Immunological Determinations in Meniere’s Disease: Any Role in Clinical Practice? European Archives of Oto-Rhino-Laryngology, 264, 15-19.

[17]   Whicher, J.T. (1980) The Interpretation of Electrophoresis. British Journal of Hospital Medicine, 24, 348, 351, 353-356.

[18]   Uchide, K., Suzuki, N., Takiguchi, T., Terada, S. and Inoue, M. (1997) The Possible Effect of Pregnancy on Meniere Disease. ORL: Journal for Oto-Rhino-Laryngology, 59, 292-295.

[19]   Fattori, B., Nacci, A., Dardano, A., Dallan, I., Grosso, M., Traino, C., Mancini, V., Ursino, F. and Monzani, F. (2008) Possible Association between Thyroid Autoimmunity and Menière’s Disease. Clinical & Experimental Immunology, 152, 28-32.

[20]   Derebery, M.J. and Berliner, K.I. (2007) Allergy and Meniere Disease. Current Allergy and Asthma Reports, 6, 451-456.

[21]   Tomiyama, S., Nonaka, M., Gotoh, Y., Ikezono, T. and Yagi, T. (1994) Immunological Approach to Meniere Disease: Vestibular Immune Injury Following Immune Reaction of the Endolymphatic Sac. ORL: Journal for Oto-Rhino-Laryngology, 56, 11-18.