Objective: To report a case of a multiple
paraganglioma with 5 concurrent locations and also describe a complication not
found in the literature, spontaneous tumor bleeding. Introduction: The
paragangliomas are mostly benign and more frequent in women. Can be multiple,
and these are considered as the most likely source of familial origin (30%-35%). The multicentric lesions can occur at
different life stages not being necessarily simultaneous, a fact that prevents
image exam research to be conclusive for tumor presence or absence. In this way
the examination of the family members of patients, specially young ones,
diagnosed with multicentric tumors may lead to negative results which doesn’t
meant that the disease can be developed at a later time period. Therefore
routine examination is not justifiable when symptoms relative to tumor presence
are not present. Case report: A female patient of 32 years old
complaining of tinnitus and diagnosed with five paragangliomas
(jugulo-timpanic, bilateral carotid body and bilateral brachiocephalic trunk)
through imaging studies. She reported suffering relatives of paragangliomas.
Conclusion: The paper reports a rare case and perhaps unique in the literature,
multiple paraganglioma with five locations and discusses difficult choice of
treatment and complications.
Cite this paper
Sales Chagas, J. , Nogueira Pascoal, M. , de Aquino, J. , Brandi Filho, L. , Fruet, F. , Rizzanti Pereira, D. , Matos, A. , Ruba, T. and Callegari, F. (2014) Multicentric Cervical Paraganglioma. Rare Case of Five Locations in One Patient. Case Report and Literature Review. International Journal of Otolaryngology and Head & Neck Surgery
, 82-88. doi: 10.4236/ijohns.2014.32017
 Suárez Nieto, C., Llorente Pendás, J.L. and Martínez, J.G. (2009) Tratamiento Quirúrgico de los Paragangliomas Vagales. Acta Otorrinolaringológica Española, 60, 97-105.
 Köhler, H.F., Carvalho, A.L., Nishinari, K. and Kowalski, L.P. (2010) Internal Carotid Artery Reconstruction after Paraganglioma Resection: Report of Six Cases and Analysis of Available Techniques. Revista Brasileira de Cirurgia de Cabeça e Pescoço, 39, 210-213.
 Isik, A.C.U., Imamoglu, A.C.E.M., Cinel, A. and Maral, A.S.G. (2006) Familial Paraganglioma. European Archives of Oto-Rhino-Laryngology, 263, 23-31. http://dx.doi.org/10.1007/s00405-004-0885-y
 Havas, T.E. and Gullane, P.J. (1989) Multicentric Chemodectoma in the Head and Neck. ANZ Journal of Surgery, 59, 641-645. http://dx.doi.org/10.1111/j.1445-2197.1989.tb01648.x
 Sobol, S.M. and Dailey, J.C. (1990) Familial Multiple Cervical Paragangliomas: Report of a Kindred and Review of the Literature. Otolaryngology—Head and Neck Surgery, 102, 382-390.
 Pellitteri, P.K., Rinaldo, A., Myssiorek, D., Jackson, C.G., Bradley, P.J., Devaney, K.O., Shaha, A.R., Netterville, J.L., Manni, J.L. and Ferlito, A. (2004) Paragangliomas of the Head and Neck. Oral Oncology, 40, 563-575.http://dx.doi.org/10.1016/j.oraloncology.2003.09.004
 Dall′Igna, C., Antunes, M.B. and Dall′Igna, D.P. (2005) Radiation Therapy for Glomus Tumors of the Temporal Bone. Brazilian Journal of Otorhinolaryngology, 71, 752-757.
 Borba, L.A.B., Araújo, J.C., Oliveira, J.G., Giudicissi Filho, M., Moro, M.S., Tirapelli, L.F. and Colli, B.O. (2009) Surgical Management of Glomus Jugulare Tumors: A Proposal for Approach Selection Based on Tumor Relationships with the Facial Nerve. The Journal of Neuroscience, 8, 1-11.
 Chung, S.M., Kim, H.S., Jung, J., Lee, H.K. and Lee, W.S. (200) Clinical Presentation and Management of Jugular Foramen Paraganglioma. Clinical and Experimental Otorhinolaryngology, 9, 28-32.http://dx.doi.org/10.3342/ceo.2009.2.1.28
 Bocian, J.J. and Tushka, O.J. (1958) Multicentric Paragangliomas. Vagal and Carotid Body Tumors. California Medicine, 88, 51-54.