We analyze oxidative activity of DNA due to
fluorescence of chromosomes inside cells, using flow cytometry method with
nanometer spatial resolution. Statistics of fluorescence is presented in
histogram as frequency distributions of flashes in the dependence on their
intensity and in distributions of Shannon entropy, which was defined on the base of normalized distribution of information in
original histogram for frequency of flashes. We show that overall sum of
entropy, i.e. total entropy E , for
any histogram is invariant and has identical trends of changes all values of
E(r) = lnr at reduction of histogram’ rank r. This invariance
reflects informational homeostasis of chromosomes activity in multi-scale
networks of entropy inside all cells in various samples of blood for DNA inside
neutrophils, lymphocytes, inside all leukocytes of human and inside chicken
erythrocytes for various dyes, colors and various excitations of fluorescence.
Informational homeostasis of oxidative activity of 3D DNA in the full set of
chromosomes inside living cells exists for any Shannon-Weaver index of
biodiversity of cells, at any state of health different beings. Regulation
perturbations in information activity DNA provides informational adaptability
and vitality of cells at homeostasis support. Noises of entropy, during
regulation of informational homeostasis, depend on the states of health in real
time. The main structural reconstructions of chromosomal correlations,
corresponding to self-regulation of homeostasis, occur in the most large-scale
networks of entropy, for rank r<32. We show that stability of homeostasis is
supported by activity of all 46 chromosomes inside cells. Patterns, hidden
switching and branching in sequences of averages of H?lder and central moments
for noises in regulation of homeostasis define new opportunities in diagnostics
of health and immunity. All people and all aerobic beings have one overall
homeostatic level for countdown of information activity of DNA inside cells. We
noted very bad and dangerous properties of artificial cells with other levels
of informational homeostasis for all aerobic beings in foods, medical treatment
and in biotechnologies.
Cite this paper
Galich, N. (2014) Invariance and Noises of Shannon Entropy for Information on Oxidative Activity of DNA in All Living Cells for Medical Diagnostics. American Journal of Operations Research
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