NM  Vol.5 No.1 , March 2014
Immunolocalization of Ephexin-1 in the Developing Canine Cerebellum
ABSTRACT

Ephexin-1 functions as guanine nucleotide exchange factors for the Rho-type GTPases which have important roles in neuronal development including axon guidance, migration, morphogenesis, and plasticity of neurons. As little is known about ephexin-1 in the cerebellum, we investigated the immunolocalization of ephexin-1 in the developing canine cerebellum. While the cellular maturation was followed by the temporal pattern, the calbindin D-28k and ephexin-1 immunoreactivities gradually increased in developing canine cerebellum. When compared to the calbindin D-28k immunoreactivities, belated ephexin-1 immunolocalization was observed in the Purkinje cells which aligned a single layer during cerebellar development. These results suggest that ephexin-1 might play an important role in the development of the Purkinje cells during the first two postnatal weeks based on its immunolocalization in the present study.


Cite this paper
Park, H. , Chang, I. , Kim, H. and Yoon, S. (2014) Immunolocalization of Ephexin-1 in the Developing Canine Cerebellum. Neuroscience and Medicine, 5, 9-14. doi: 10.4236/nm.2014.51002.
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