IJOC  Vol.4 No.1 , March 2014
Highly-Efficient Conversion of Primary Amides to Nitriles Using Indium(III) Triflate as the Catalyst
ABSTRACT
Indium(III) triflate, a trivalent indium reagent, was shown to be a highly-efficient catalyst for the conversion of primary amides to the corresponding nitriles. The successful reactions required 5 mol% of indium(III) triflate, and toluene was proved to be the most suitable solvent. Various amides were subjected to this method, and each produced the corresponding nitriles in excellent yields.

Cite this paper
Mineno, T. , Shinada, M. , Watanabe, K. , Yoshimitsu, H. , Miyashita, H. and Kansui, H. (2014) Highly-Efficient Conversion of Primary Amides to Nitriles Using Indium(III) Triflate as the Catalyst. International Journal of Organic Chemistry, 4, 1-6. doi: 10.4236/ijoc.2014.41001.
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