NM  Vol.2 No.1 , March 2011
Reduced Risk of Cancer in Patients with Bipolar Affective Disorder
Abstract: Background: research focusing on incidence of cancer amongst bipolar affective disorder (BAD) is sparse. Aim: to ex-amine the incidence of cancer in a cohort of BAD inpatients. Methods: the study sample was comprised of BAD patients who had been admitted to a tertiary care mental health center during the period: 1990 to 2006. The data for the sample was cross-referenced with the National Cancer Registry. Analyses of Standardized Incidence Rates (SIR) for all organ systems malignancies were performed. Results: of 1,638 BAD patients included in the present study, 72 (0.04%) were diagnosed as suffering from co-morbid malignancy. This reflects a significantly reduced risk; SIR of 0.27 (95% CI 0.21-0.34). Reduced risk of cancer held true for both males and females (0.20 and 0.34, respectively). Nineteen women developed breast cancer; SIR = 0.42 (95% CI 0.25-0.66). Conclusions: the present study demonstrates reduced rates of cancer amongst patients suffering from BAD - with special reduction in breast cancer.
Cite this paper: nullE. Rosenshfir, P. Shemesh, D. Aizenberg and Y. Barak, "Reduced Risk of Cancer in Patients with Bipolar Affective Disorder," Neuroscience and Medicine, Vol. 2 No. 1, 2011, pp. 57-60. doi: 10.4236/nm.2011.21008.

[1]   J. A. Pandiani, M. M. Boyd, S. M. Banks and A. T. Johnson, “Elevated Cancer Incidence among Adults with Serious Mental Illness,” Psychiatric Services, Vol. 57, No. 7, 2006, pp. 1032-1034. doi:10.1176/

[2]   Y. Barak, T. Levy, A. Achiron and D. Aizenberg, “Breast Cancer in Women Suffering from Serious Mental Illness,” Schizophrenia Research, Vol. 102, No. 1-3, 2008, pp. 249-253. doi:10.1016/j.schres.2008.03.017

[3]   V. S. Catts, S. V. Catts, B. I. O’Toole and A. D, “Frost. Cancer Incidence in Patients with Schizophrenia and Their First-Degree Relatives—A Meta-Analysis,” Acta Psychiatrica Scandinavica, Vol. 117, 2008, pp. 323-336. doi:10.1111/j.1600-0447.2008.01163.x

[4]   C. P. Carney and L. E. Jones, “Medical Co-Morbidity in Women and Men with Bipolar Disorders: A Population-Based Controlled Study,” Psychosomatic Medicine, Vol. 68, No. 5, 2006, pp. 684-691. doi:10.1097/01.psy.0000237316.09601.88

[5]   J. Hippisley-Cox, Y. Vinogradova, C. Coupland and C. Parker, “Risk of Malignancy in Patients with Schizophrenia or Bipolar Disorder: Nested Case-Control Study,” Archives of General Psychiatry, Vol. 64, No. 12, 2007, pp. 1368-1376. doi:10.1001/archpsyc.64.12.1368

[6]   Y. Cohen, A. Chetrit, Y. Cohen, P. Sirota and B. Modan, “Cancer Morbidity in Psychiatric Patients: Influence of Lithium Carbonate Treatment,” Medical Oncology, Vol. 15, No. 1, 1998, pp. 32-36. doi:10.1007/BF02787342

[7]   K. R. Krishnan, “Psychiatric and Medical Comorbidities of Bipolar Disorder,” Psychosomatic Medicine, Vol. 67, 2005, pp. 1-8. doi:10.1097/01.psy.0000151489.36347.18

[8]   J. S. Wang, C. L. Wang, J. F. Wen, Y. J. Wang, Y. B. Hu and H. Z. Ren, “Lithium Inhibits Proliferation of Human Esophageal Cancer Cell Line Eca-109 by Inducing a G(2)/M Cell Cycle Arrest,” World Journal of Gastroenterology, Vol. 14, 2008, pp. 3982-3989. doi:10.3748/wjg.14.3982

[9]   A. B. Sabin, “Proceedings: Cancer Research in Israel: Work of Academic Institutions and National Cancer Registry,” National Cancer Institute Monograph, Vol. 40, 1974, pp. 57-62.

[10]   P. Lichtenstein, B. H. Yip, C. Bj?rk, Y. Pawitan, T. D. Cannon, P. F. Sullivan, et al., “Common Genetic Determinants of Schizophrenia and Bipolar Disorder in Swedish Families: A Population-Based Study,” Lancet, Vol. 373, No. 9659, 2009, pp. 234-139. doi:10.1016/S0140-6736(09)60072-6

[11]   Y. Benjamini and Y. Hochberg, “Controlling the False Discovery Rate (FDR): A Practical and Powerful Approach to Multiple Testing,” Journal of the Royal Statistical Society, Vol. 57, 1995, pp. 289-300.

[12]   Y. Barak, A. Achiron, M. Mandel, I. Mirecki and D. Aizenberg, “Reduced Cancer Incidence among Patients with Schizophrenia,” Cancer, Vol. 104, No. 12, 2005, pp. 2817-2821. doi:10.1002/cncr.21574

[13]   M. BarChana, I. Levav, I. Lipshitz, I. Pugachova, R. Kohn, A. Weizman, et al., “Enhanced Cancer Risk among Patients with Bipolar Disorder,” Journal of Affective Disorders, Vol. 108, No. 1-2, 2008, pp. 43-48. doi:10.1016/j.jad.2007.09.003

[14]   J. Mirsky, R. Kohn, I. Levav, A. Grinshpoon and A. M. Ponizovsky, “Psychological Distress and Common Mental Disorders among Immigrants: Results from the Israeli-Based Component of the World Mental Health Survey,” Journal of Clinical Psychiatry, Vol. 69, No. 11, 2008, pp. 1715-1720. doi:10.4088/JCP.v69n1106