ARSci  Vol.2 No.1 , February 2014
Impact of the professional exposure on the spermatic parameters and the results of ICSI at Tunisian unfertile couples
ABSTRACT
Introduction: The association of the professional exposure to the decline of the male reproductive function had been the subject of several studies but without arriving to one envisagement undeniable of its existence. The ICSI, technique of reference in severe male infertilities, is visavis unexplained failures whose environmental and professional exposure could be about its cause partly. In this work, we tried to highlight an association between certain factors of professional exposure and the deterioration of the spermatic parameters, then to evaluate the effect of such factors on the result of the ICSI. Materials and Methods: It is about a study of the exposed type—no exposed, realized through collaboration between the Unit of Medicine of the Reproduction and the Service of Medicine of Work of the CHU Farhat Hached of Sousse. This study was based on a questionnaire of which part of the items was collected medical files of the patients raising the general characteristics, the profile of exposure as well as the spermatic parameters and the biological assessment of ICSI. Results: Significant associations between the deterioration of sperm and the professional risk factors such as the exposure to the formaldehydes (p = 0.01) and heat (p = 0.001) were noted. The exposure to formaldehydes was associated at the higher risk of oli gozoospermy, of asthenozoospermy with a significant reduction in mobility (p = 0.05), whereas the talks with cement had a risk higher of teratozoospermy. In addition an exposure to heat was associated at the high risk of oligoteratozoospermy. The total rate of pregnancies after ICSI among 220 patients of our series was of 14.47%. The ICSI balance showed a reduction in total fertility rate (76.6% exposed vs 75.3% no exposed). Conclusion: In spite of the limited number of the patients, this study had shown a correlation between certain professional exposures of origin and the deterioration of sperm. They are preliminary results which encourage continuing collaboration between the specialists in the reproduction and the doctors of work in order to preserve the fertility of the workers exposed to factors gonadotoxic.

Cite this paper
Ali, H. , Zaouali, M. , Atig, F. , Bougmiza, I. , Mehri, S. , Frej, H. , Tabka, F. , Saad, A. and Ajina, M. (2014) Impact of the professional exposure on the spermatic parameters and the results of ICSI at Tunisian unfertile couples. Advances in Reproductive Sciences, 2, 24-31. doi: 10.4236/arsci.2014.21004.
References
[1]   Mosher, W.D. and Pratt, W.F. (1991) Fecundity and infertility in the United States: Incidence and trends. Fertility and Sterility, 56, 192-193.

[2]   Skakkebaek, N.E., Giwercman, A. and de Kretser, D. (1994) Pathogenesis and management of male infertility. Lancet, 343, 1473-1478. http://dx.doi.org/10.1016/S0140-6736(94)92586-0

[3]   Stoy, J., Hjollund, N.H., Mortensen, J.T., et al. (2004) Semen quality and sedentary work position. International Journal of Andrology, 27, 5-11. http://dx.doi.org/10.1046/j.0105-6263.2003.00428.x

[4]   Kurinczuk, J.J. and Clarke, M. (2001) Case-control study of leatherwork and male infertility. Occupational and Environmental Medicine, 58, 217-224. http://dx.doi.org/10.1136/oem.58.4.217

[5]   Welch, L.S., Schrader, S.M. and Turner, T.W. (1988) Effects of exposure to ethylene glycol ethers on shipyard painters: II. Male reproduction. American Journal of Industrial Medicine, 14, 509-526. http://dx.doi.org/10.1002/ajim.4700140503

[6]   Bujan, L., Daudin, M., Charlet, J.P., et al. (2000) Increase inscrotal temperature in car drivers. Human Reproduction, 15, 1355-1357. http://dx.doi.org/10.1093/humrep/15.6.1355

[7]   Gracia, C.R., Sammel, M.D., Coutifaris, C., et al. (2005) Occupational exposures and male infertility. American Journal of Epidemiology, 162, 729-733. http://dx.doi.org/10.1093/aje/kwi269

[8]   Wong, W.Y., Zielhuis, G.A., Thomas, C.M., et al. (2003) New evidence of the influence of exogenous and endogenous factors on sperm count in man. European Journal of Obstetrics & Gynecology and Reproductive Biology, 110, 49-54. http://dx.doi.org/10.1016/S0301-2115(03)00162-3

[9]   Guo, Y.L., Hsu, P.C., Hsu, C.C., et al. (2000) Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans. Lancet, 356, 1240-1241. http://dx.doi.org/10.1016/S0140-6736(00)02792-6

[10]   Rignell-Hydbom, A., Rylander, R., Giwercman, A., et al. (2004) Exposure to CB-153 and p,p0-DDE and male reproductive function. Human Reproduction, 19, 2066- 2075. http://dx.doi.org/10.1093/humrep/deh362

[11]   Elzanaty, S., Richthoff, J., Malm, J., et al. (2002) The impact of epididymal and accessory sex gland function on sperm motility. Human Reproduction, 17, 2904-2911.

[12]   Richthoff, J., Spano, M., Giwercman, Y.L., et al. (2002) The impact of testicular andaccessory sex gland function on sperm chromatin integrity as assessed bythe sperm chromatin structure assay (SCSA). Human Reproduction, 17, 3162-3169. http://dx.doi.org/10.1093/humrep/17.12.3162

[13]   Enmark, E., Pelto-Huikko, M., Grandien, K., et al. (1997) Human estrogen receptor bgenestructure, chromosomal localization and expression pattern. Journal of Clinical Endocrinology and Metabolism, 82, 4258-4265.

[14]   Arbuckle, T.E. and Sever, L.E. (1998) Pesticide exposures and fetal death: A review of the epidemiologic literature. Critical Reviews in Toxicology, 28, 229-270. http://dx.doi.org/10.1080/10408449891344218

[15]   WHO (1999) WHO laboratory manual for examination of human semen and sperm—Cervical mucus interaction. CUP, Cambridge.

[16]   David, G., Bisson, J.P. and Czyglic, F. (1975) Anomalies morphologiques du spermatozo?de humain 1) propositions pour un système declassification. Journal de Gynécologie, Obstétrique et Biologie de la Reproduction, 4, 17-36.

[17]   Jouannet, P., Ducot, B., Feneux, D., et al. (1988) Male factors and the likehood of pregnancy in infertile couples. I. Study of sperm characteristics. International Journal of Andrology, 11, 379-384. http://dx.doi.org/10.1111/j.1365-2605.1988.tb01011.x

[18]   Englert, Y., Van den Bergh, M., Rodesch, C., et al. (1991) Nouveau programme de fécondation in vitro à l’h?pital erasme: Premiers résultats originaux. Revue Médicale de Bruxelles, 12, 305-314.

[19]   Puissant, F., Van Rysselberge, M., Barlow, P., et al. (1987) Embryo sconing as a pronostic tool in IVF treatment. Human Reproduction, 2, 705-708.

[20]   Keck, C., Bergmann, M., Ernst, E., et al. (1993) Auto- metallographic detection of mercury in testicular tissue of aninfertile man exposed to mercury vapor. Reproductive Toxicology, 7, 469-475. http://dx.doi.org/10.1016/0890-6238(93)90092-L

[21]   Skakkeb?k, N.E., J?rgensen, N., Main, K.M., et al. (2006) Is human fecundity declining? International Journal of Andrology, 29, 2-11. http://dx.doi.org/10.1111/j.1365-2605.2005.00573.x

[22]   Carlsen, E., Andersson, A.M., Petersen, J.H., Skakkebaek, N.E., et al. (2003) History offebrile illness and variation in semen quality. Human Reproduction, 18, 2089-2092. http://dx.doi.org/10.1093/humrep/deg412

[23]   Telisman, S., Cvitkovic, P., Jurasovic, J., et al. (2000) Semen quality and reproductive endocrine function in relation tobiomarkers of lead, cadmium, zinc and copper in men. Environmental Health Perspectives, 108, 45-53. http://dx.doi.org/10.1289/ehp.0010845

[24]   Sheiner, E.K., Sheiner, E., Hammel, R.D., et al. (2003) Effect of occupational exposures on male fertility: Literature review. Industrial Health, 41, 55-62. http://dx.doi.org/10.2486/indhealth.41.55

[25]   Cherry, N., Moore, H., McNamee, R., et al. (2008) Participating centres of Chaps-UK, Occupation and male infertility: Glycol ethers and other exposures. Occupational and Environmental Medicine, 65, 708-714. http://dx.doi.org/10.1136/oem.2007.035824

[26]   Gaspari, L., Chang, S.S., Santella, R.M., et al. (2002) Polycyclic aromatic hydrocarbon-DNA adducts in human sperm as a marker of DNA damage and infertility. Mutation Research, 535, 155-160. http://dx.doi.org/10.1016/S1383-5718(02)00297-8

[27]   Hsu, P.C., Chen, I.Y., Pan, C.H., et al. (2006) Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers. International Archives of Occupational and Environmental Health, 79, 349-356. http://dx.doi.org/10.1007/s00420-005-0066-3

[28]   Figa Talamanca, I., Dell’Orco, V., Pupi, A., et al. (1992) Fertility and semen quality of workers exposed to high temperatures in the ceramics industry. Reproductive Toxicology, 6, 517-523. http://dx.doi.org/10.1016/0890-6238(92)90036-S

[29]   Bartoov, B., Berkovitz, A., Eltes, F., et al. (2003) Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection. Fertility and Sterility, 80, 1413-1419. http://dx.doi.org/10.1016/j.fertnstert.2003.05.016

[30]   Van Dyk, Q., Lanzerdorf, S., Kolm, P., et al. (2000) Incidence of aneuploide spermatozoa from subfertile men: selected with motility versus hemizona bound. Human Reproduction, 15, 1529-1536. http://dx.doi.org/10.1093/humrep/15.7.1529

[31]   Saleh, R.A., Agarwal, A., Sharma, R.K., et al. (2003) Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele. Fertility and Sterility, 80, 1431-1436. http://dx.doi.org/10.1016/S0015-0282(03)02211-8

 
 
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