The occurrence of
multiple primary cancers is rare; it can be missed as a disease progression.
The etiology remains controversial. We report a case of a 55-year-old female
with metastatic renal cell carcinoma treated with sutent followed by left sided
nephrectomy. Follow-up CT showed increase in the size of the right axillary
lymph nodes which was proven after biopsy to be metastatic adenocarcinoma of
the breast. Any suspicious disease progression in a single site not
compatible with disease history should be biopsied for confirmation. The
relationship between renal cell carcinoma and breast cancer is still unclear,
and more case reports are required to determine this relationship.
Cite this paper
Ahmed, O. and Abbas, T. (2014) Metachronous double malignancy involving the kidney and the breast: A case report. Case Reports in Clinical Medicine
, 67-69. doi: 10.4236/crcm.2014.32016
 Dalal, S., et al. (2008) Synchronous double malignancy: Adeno-carcinoma of caecum and renal cell carcinoma. The Internet Journal of Gastroenterology, 6, 4.
 Mesmoudi, M., et al. (2011) Triple malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature. Journal of Medical Case Reports, 5, 462.http://dx.doi.org/10.1186/1752-1947-5-462
 Cheng, J.H., et al. (2008) Double primary bronchogenic carcinoma of the lung and papillary thyroid carcinoma: A case report. Journal of Medical Case Reports, 2, 309.http://dx.doi.org/10.1186/1752-1947-2-309
 Raissouni, S., et al. (2012) Radiation induced esophageal adenocarcinoma in a woman previously treated for breast cancer and renal cell carcinoma. BMC Research Notes, 5, 426. http://dx.doi.org/10.1186/1756-0500-5-426
 Fletcher, H., et al. (2007) Multiple metachronous malignancies, one patient with three primary malignancies: A case report. Journal of Medical Case Reports, 1, 15.http://dx.doi.org/10.1186/1752-1947-1-15
 Albiges, L. and Escudier, B. (2011) Vascular endothelial growth factor-targeted therapy for the treatment of renal cell carcinoma. Drugs, 71, 1179.http://dx.doi.org/10.2165/11591410-000000000-00000
 Aapro, M. (2009) Sunitinib and metastatic breast cancer. Advances in Oncology, 4, 18.
 Conley, S.J., et al. (2012) Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proceedings of the National Academy of Sciences of USA, 109, 2784-2789.