Melatonin is a safe and effective treatment for patients with functional pain
and gastrointestinal disorders. Objective: To evaluate the efficacy and
safety of melatonin for 3 months in patients with functional heartburn.
Methods: In the randomized, placebo-controlled pilot study, patients with
functional heartburn were treated with omeprazole 20 mg before breakfast and randomized to receive either
melatonin 6 mg (n = 20),
nortripty line 25 mg (n = 20), or
placebo (n = 20) at bedtime for 3
months. Gastroesophageal Reflux Disease-Health-Related
Quality of Life (GERD-HRQOL) scores were assessed at baseline and at the
end of the study. Results: Melatonin improved GERD-HRQOL scores compared with
nortriptyline (P = 0.0015) and
placebo (P < 0.0001). Fewer
adverse events were reported by patients receiving melatonin compared with
those receiving nortriptyline or placebo. Conclusions: Melatonin was a safe
and effective treatment for functional heartburn.
Cite this paper
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