To explore the effects of Anwei decoction (AD) on the protein expression of TFF
in rats with chronic atrophic gastritis(CAG). Methods: Forty-eight healthy rats
were randomly divided into 4 groups: normal control group, pathologic model
group, Anwei Decoction group, and Weifuchun group. CAG was induced in rats with
N-methy-N-nitro-N-nitrogua-nidine (MNNG). The protein expression of TFF in
rats’ gastric mucosa was determined by immunohistochemistry. Results: Compared
with that in the normal control group, the protein expression of TFF1 was
significantly enhanced in the pathologic model, Anwei Decoction and Weifuchun
groups (both P < 0.01). The protein expression level of TFF1 was significantly higher in the Anwei Decoction
group than in the Weifuchun group (P < 0.01). Compared with the normal
control group, the protein expression of TFF2 was significantly enhanced in the
pathologic model, Anwei Decoction and Weifuchun groups (both P < 0.01). The
protein expression level of TFF2 was significantly higher in the Anwei
Decoction group than in the Weifuchun group (P < 0.01). In comparison with
the pathologic model group, the protein
expression of TFF3 was remarkably reduced in Anwei Decoction and
Weifuchun groups (both P < 0.01). but there was no difference between the
group of Anwei decoction and the group of Weifuchun (P > 0.05). Conclusion:
Anwei decoction may be effective in the treatment of CAG by enhancing the
protein expression of TFF1, TFF2 while reducing that of TFF3 in gastric mucosas.
Cite this paper
Wei, W. , Lin, S. and Zhu, Y. (2014) Effects of Anwei decoction on the protein expression of TFF in rats with chronic atrophic gastritis. Modern Research in Inflammation
, 1-6. doi: 10.4236/mri.2014.31001
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