ABB  Vol.5 No.3 , February 2014
IL-4, IL-6, IL-10, IL-17A and vascular endothelial growth factor in the vitreous of patients with proliferative diabetic retinopathy
ABSTRACT

In current article, results of the determination of the concentrations of vascular endothelial growth factor (VEGF), and some interleukins (IL-4, IL-6, IL-10, IL-17А) in the vitreous of patients with proliferative diabetic retinopathy are presented. We have found that in the mechanism of development of diabetic retinopathy, significant role plays an activation of local inflammation process and vascular proliferation. This is evidenced by a significant increase in the vitreous concentration of IL-4, IL-6, IL-10, IL-17A and vascular endothelial growth factor. Identified correlations between VEGF and IL-17A, between VEGF and IL-4, and between IL-17A and IL-4 show the relationship of inflammation and proliferation processes in the pathogenesis of diabetic retinopathy.


Cite this paper
Chernykh, V. , Smirnov, E. , Varvarinsky, Y. , Chernykh, D. , Obukhovа, O. and Trunov, A. (2014) IL-4, IL-6, IL-10, IL-17A and vascular endothelial growth factor in the vitreous of patients with proliferative diabetic retinopathy. Advances in Bioscience and Biotechnology, 5, 184-187. doi: 10.4236/abb.2014.53023.
References
[1]   Balashevich, L.I. (2004) Ocular manifestations of diabetes. Medical Academy of Postgraduate Education, St. Petersburg, 382.

[2]   Libman, E.S., and Shahova, E.V. (2006) Blindness and disability due to pathology of the vision in Russia. Journal of Ophthalmology, 122, 35-37.

[3]   Bhavsar, A.R. (2006) Diabetic retinopathy: The latest in current management. Retina, 26, 71-79.
http://dx.doi.org/10.1097/00006982-200607001-00016

[4]   Lim, A., Stewart, J., Chui, T.Y., Lin, M., Ray, K., Lietman, T., Porco, T., Jung, L., Seiff, S. and Lin, S. (2008) Prevalence and risk factors of diabetic retinopathy in a multi-racial underserved population. Ophthalmic Epidemiology, 15, 402-409.
http://dx.doi.org/10.1080/09286580802435179

[5]   Kollias, A.N. and Ulbig, M.W. (2010) Diabetic retinopathy: Early diagnosis and effective treatment. Deutsches Ärzteblatt international, 107, 75-83.

[6]   Sadaka, A. and Giuliari, G.P. (2012) Proliferative vitreoretinopathy: Current and emerging treatments. Journal of Clinical Ophthalmology, 6, 1325-1333.

[7]   Chernykh, V.V., Lysikov, A.G., Obukhova, O.O., Gorbenko, O.M., Shvayuk, A.P. and Trunov, A.N. (2011) Features of local immunoinflammatory process at nonproliferative diabetic retinopathy. Bulletin of the Novosibirsk State University, 9, 164-168.

[8]   Khodjaev, N.S., Chernykh, V.V., Romenskaya, I.V., Kuntysheva, K.E. and Trunov, A.N. (2011) Effect of laser coagulation retina on clinical-laboratory parameters in patients diabetic macular edema. Bulletin of the Novosibirsk State University, 9, 48-53.

[9]   Kowluru, R.A., Zhong, Q. and Kanwar, M. (2010) Metabolic memory and diabetic retinopathy: Role of inflammatory mediators in retinal pericytes. Experimental Eye Research, 90, 617-623.
http://dx.doi.org/10.1016/j.exer.2010.02.006

[10]   Rasier, R., Gormus, U., Artunay, O., Yuzbasioglu, E., Oncel, M. and Bahcecioglu, H. (2010) Vitreous levels of VEGF, IL-8, and TNF-alpha in retinal detachment. Current Eye Research, 35, 505-509.
http://dx.doi.org/10.3109/02713681003597248

[11]   Symeonidis, C., Papakonstantinou, E., Androudi, S., Rotsos, T., Diza, E., Brazitikos, P., Karakiulakis, G. and Dimitrakos, S.A. (2011) Interleukin-6 and the matrix metalloproteinase response in the vitreous during proliferative vitreoretinopathy. Cytokine, 54, 212-217.
http://dx.doi.org/10.1016/j.cyto.2011.02.001

[12]   Slepova, O.S., Neroev, V.V., Ilyukhin, P.A. and Sarygina, O.I. (2012) Immunological control of in the surgical treatment of patients with proliferative diabetic retinopathy with preliminary introduction to the vitreous Lucentis. Russian Ophthalmological Journal, 1, 69-74.

[13]   Citirik, M., Kabatas, E.U., Batman, C., Akin, K.O. and Kabatas, N. (2012) Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy. Ophthalmic Research, 47, 7-12. http://dx.doi.org/10.1159/000324200

[14]   Pennock, S. and Kazlauskas, A. (2012) Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responses. Molecular and Cellular Biology, 32, 1955-1966.
http://dx.doi.org/10.1128/MCB.06668-11

[15]   Murugeswari, P., Shukla, D., Rajendran, A., Kim, R., Namperumalsamy, P. and Muthukkaruppan, V. (2008) Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eyes disease. Retina, 28, 817-824. http://dx.doi.org/10.1097/IAE.0b013e31816576d5

[16]   Mohan, N., Monickaraj, F., Balasubramanyam, M., Rema, M. and Mohan, V. (2012) Imbalanced levels of angiogenic and angiostatic factors in vitreous, plasma and postmortem retinal tissue of patients with proliferative diabetic retinopathy. Journal of Diabetes and its Complications, 26, 435-441.
http://dx.doi.org/10.1016/j.jdiacomp.2012.05.005

[17]   Wakabayashi, Y., Usui, Y., Okunuki, Y., Kezuka, T., Takeuchi, M., Goto, H. and Iwasaki, T. (2010) Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy. Retina, 30, 339-344.
http://dx.doi.org/10.1097/IAE.0b013e3181bd2f44

[18]   Kang, M.H., Kim, M.K., Lee, H.J., Lee, H.I., Wee, W.R. and Lee, J.H. (2011) Interleukin-17 in various ocular surface inflammatory diseases. Journal of Korean Medical Science, 26, 938-944.
http://dx.doi.org/10.3346/jkms.2011.26.7.938

[19]   Regan, D.P., Aarnio, M.C., Davis, W.S., Carmichael, K.P., Vandenplas, M.L., Lauderdale, J.D. and Moore, P.A. (2012) Characterization of cytokines associated with Th17 cells in the eyes of horses with recurrent uveitis. Veterinary Ophthalmology, 15, 145-152.
http://dx.doi.org/10.1111/j.1463-5224.2011.00951.x

[20]   Neurath, M.F. and Finotto, S. (2011) IL-6 signaling in autoimmunity, chronic inflammation and inflammationassociated cancer. Cytokine & Growth Factor Reviews, 22, 83-89. http://dx.doi.org/10.1016/j.cytogfr.2011.02.003

[21]   Suzuki, Y., Nakazawa, M., Suzuki, K., Yamazaki, H. and Miyagawa, Y. (2011) Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion. Japanese Journal of Ophthalmology, 55, 256-263.
http://dx.doi.org/10.1007/s10384-011-0004-8

 
 
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