Background: Mosquito bite reaction is a common skin disease. Topical steroids and oral antihistamines are the conventional treatment. However, the side effects from prolonged use of topical steroids are the limitation of the treatment. Recently, herbal extracts are emerging interest for an alternative anti-inflammatory dermatoses therapy. Objective: To assess the effectiveness of herbal extracted gel containing, Perilla frutescens, Portulaca oleracea, Ipomoea pescaprae, Aloe vera, Centella asiatica and Broussonetia papyrifera in comparing with 1% hydrocortisone (HC) gel. Material and Methods: An experimental study was conducted on 50 mosquito bite hypersensitive volunteers (15 - 19 years old) with double-blinded split randomized control method. After the volunteers were exposed for one bite on their arms by a non-infectious mosquito, Aedes albopictus, the drugs were applied twice daily. The diameter of lesion, pruritus analog score, erythema and melanin index were measured at 2, 6, 24 hours and 2, 3, 4 weeks. The volunteers “self-satisfaction” and side effects were recorded. Results: The mean age was 17.42 ± 1.14 years old. The diameter of lesion, pruritus analog score, erythema and melanin index were decreased on both sides at each visit with significant difference (p < 0.05). There was no significant difference between two agents of all parameters and the satisfaction of the volunteers (p > 0.05). The post-inflammatory hyperpigmentation rate of 1% HC and herbal gel was 64% and 54% respectively without significant difference (p = 0.267). Conclusion: The herbal gel was as effective as 1% HC for the treatment of acute and late reaction of mosquito bite reaction in adolescent. It may be used as the alternative treatment for mosquito bite reaction.
 K. Oka and N. Ohtaki, “Clinical Observations of Mosquito Bite Reactions in Man: A Survey of the Relationship between Age and Bite Reaction,” The Journal of Dermatology, Vol. 16, 1989, pp. 212-219.
 K. Kulthanan, S. Wongkamchai and D. Triwongwaranat, “Mosquito Allergy: Clinical Features and Natural Course,” Journal of Dermatology, Vol. 37, No. 12, 2010, pp. 1025-1031.
 T. Reunala, H. Brummer-Korvenkontio, A. Karppinen, P. Coulie and T. Palosuo, “Treatment of Mosquito Bites with Cetirizine,” Clinical and Experimental Allergy, Vol. 23, No. 1, 1993, pp. 72-75. http://dx.doi.org/10.1111/j.1365-2222.1993.tb02487.x
 J. H. Klotz, S. A. Klotz and J. L. Pinnas, “Animal Bites and Stings with Anaphylactic Potential,” The Journal of Emergency Medicine, Vol. 36, No. 2, 2009, pp. 148-156.
 M. Udompataikul and W. Srisatwaja, “Comparative Trial of Moisturizer Containing Licochalcone A vs Hydrocortisone Lotion in the Treatment of Childhood Atopic Dermatitis: A Pilot Study,” Journal of the European Academy of Dermatology and Venerology, Vol. 25, No. 6, 2010, pp. 660-665.
 U. Pongprayoon, P. Baeckstrom, U. Jacobsson, M. Lindstrom and L. Bohlin, “Compounds Inhibiting Prostaglandin Synthesis Isolated from Ipomoea Pes-Caprae,” Planta Medica, Vol. 57, No. 6, 1991, pp. 515-518. http://dx.doi.org/10.1055/s-2006-960196
 C. A. Dunstan, Y. Noreen, G. Serrano, P. A. Cox, P. Perera and L. Bohlin, “Evaluation of Some Samoan and Peruvian Medicinal Plants by Prostaglandin Biosynthesis and Rat Ear Oedema Assays,” Journal of Ethnopharmacology, Vol. 57, No. 1, pp. 35-56. http://dx.doi.org/10.1016/S0378-8741(97)00043-3
 T. Makino, Y. Furuta, H. Wakushima, H. Fuji, K. Saito and Y. Kano, “Anti-Allergic Effect of Perillafrutescens and Its Active Constituents,” Phytotherapy Research, Vol. 17, No. 3, 2003, pp. 240-243. http://dx.doi.org/10.1002/ptr.1115
 C. Sanbongi, H. Takano, N. Osakabe, N. Sasa, M. Natsume, R. Yanagisawa, et al., “Rosmarinic Acid in Perilla Extract Inhibits Allergic Inflammation Induced by Mite Allergen, in a Mouse Model,” Clinical & Experimental Allergy, Vol. 34, No. 6, 2004, pp. 971-977. http://dx.doi.org/10.1111/j.1365-2222.2004. 01979.x
 K. Inoue, H. Takano, A. Shiga, Y. Fujita, H. Makino, R. Yanagisawa, et al., “Effects of Volatile Constituents of a Rosemary Extract on Allergic Airway Inflammation Related to House Dust Mite Allergen in Mice,” International Journal of Molecular Medicine, Vol. 16, No. 2, 2005, pp. 315-319.
 M. Sanchez-Compillo, J. A. Gabaldon, J. Castillo, O. Benavente-Garcia, M. J. Del Bano, M. Alcaraz, et al., “Rosmarinic Acid, a Photo-Protective Agent against UV and Other Ionizing Radiations,” Food and Chemical Toxicology, Vol. 47, No. 2, 2009, pp. 386-392. http://dx.doi.org/10.1016/j.fct.2008.11.026
 K. Chan, M. W. Islam, M. Kamil, R. Radhakrishnan, M. N. M. Zakaria, M. Habibullah, et al., “The Analgesic and Anti-Inflammatory Effects of Portulaca oleracea L. Subsp. sativa (Haw.) Celak,” Journal of Ethnopharmacology, Vol. 73, No. 3, 2000, pp. 445-451. http://dx.doi.org/10.1016/S0378-8741(00) 00318-4
 Y. Y. Lim, H. M. Kim, W. S. Park, J. H. Kim, H. J. Shin, M. N. Kim, et al., “Anti-Inflammatory and Anti-Pruritic Effects of Portulaca oleracea L. Extract Using in Vitro and in Vivo Inflammation Model: LPS-Treated Raw264.7 Cells, Keratinocytes, NC/Nga Mice and Hairless SKH-1 Mice,” Korean Journal of Asthma, Allergy and Clinical Immunology, Vol. 31, No. 3, 2011, pp. 199-206.
 B. Vazquez, G. Avila, D. Segura and B. Escalante, “Anti-Inflammatory Activity of Extracts from Aloe Verage,” Journal of Ethnopharmacology, Vol. 55, No. 1, 1996, pp. 69-75. http://dx.doi.org/10.1016/ S0378-8741(96)01476-6
 T. A. Syed, S. A. Ahmad, A. H. Holt, S. H. Ahmad and M. Afzal, “Management of Psoriasis with Aloe Vera Extract in a Hydrophilic Cream: A Placebo-Controlled, Double-Blind Study,” Tropical Medicine & International Health, Vol. 1, No. 4, 1996, pp. 505-509. http://dx.doi.org/10.1046/j.1365-3156.1996. d01-91.x
 D. Duansak, J. Somboonwonng and S. Patumraj, “Effects of Aloe Vera on Leukocyte Adhesion and TNF-Alpha and IL-6 Levels in Burn Wounded Rats,” Clinical Hemorheology and Microcirculation, Vol. 29, No. 3-4, 2003, pp. 239-246.
 L. Langmead, R. J. Makins and D. S. Rampton, “AntiInflammatory Effects of Aloe Vera Gel in Human Colorectal Mucosa in Vitro,” Alimentary Pharmacology & Therapeutics, Vol. 19, No. 5, 2004, pp. 521-527. http://dx.doi.org/10.1111/j.1365-2036.2004.01874.x
 J. Somboonwond, S. Thanamittramanee, A. Jariyapongskul and S. Patumraj, “Therapeutic Effects of Aloe Vera on Cutaneous Microcirculation and Wound Healing in Second Degree Burn Model in Rats,” Journal of the Medical Association of Thailand, Vol. 83, No. 4, 2000, pp. 417-425.
 V. Visuthikosol, B. Chowchuen, Y. Sukwanarat, S. Sriurairatana and V. Boonpucknavig, “Effect of Aloe Vera Gel to Healing of Burn Wound a Clinical and Histologic Study,” Journal of the Medical Association of Thailand, Vol. 78, No. 8, 1995, pp. 403-409.
 Z.-P. Zheng, K.-W. Cheng, J. F. Chao, J. J. Wu and M. F. Wang, “Tyrosinase Inhibitors from Paper Mulberry (Broussonetia papyrifera),” Food Chemistry, Vol. 106, No. 2, 2008, pp. 529-535.
 J.-H. Hwang and B. M. Lee, “Inhibitory Effects of Plant Extracts on Tyrosinase, L-DOPA Oxidation, and Melanin Synthesis,” Journal of Toxicology and Environmental Health, Part A, Vol. 70, No. 5, 2007, pp. 393-407. http://dx.doi.org/10.1080/10937400600882871