ABB  Vol.5 No.2 , January 2014
A comprehensive meta-analysis of the association between three IL1B polymorphisms and rheumatoid arthritis
ABSTRACT

Rheumatoid arthritis (RA) is an immune-mediated chronic inflammatory disease that causes huge destruction to human body. IL1B encodes key mediator IL-1β protein, which plays an important role in the pathogenesis of inflammatory syndromes. The aim of this study was to evaluate the association between IL1B polymorphisms and RA. A meta-analysis was performed on the association between three IL1B polymorphisms (IL1B-31: rs1143627; IL1B-511: rs16944; IL1B + 3954: rs1143634) and RA. A trend of significant association was observed between IL1B + 3954 and RA (p = 0.06, odd ratio (OR) = 1.19, 95% confidential interval (CI) = 1.00-1.42). A significant association was found in Europeans under the dominant model between IL1B-511T and RA (p = 0.03, OR = 0.89, 95% CI = 0.81-0.99). Our meta-analysis indicated that IL1B ? 511-T played a protective role against RA in Europeans, and that IL1B + 3954-T had the potential to increase the risk of RA. Future large-scale studies should be considered to confirm the association between IL1B polymorphisms and RA.


Cite this paper
Dai, D. , Wang, L. , Xu, L. , Tang, L. , Xu, X. , Ye, H. , Zhou, X. , Chen, C. , Pan, G. , Ru, P. , Ma, Q. , Jiang, Y. , Yu, W. , Xu, L. , Ye, M. and Duan, S. (2014) A comprehensive meta-analysis of the association between three IL1B polymorphisms and rheumatoid arthritis. Advances in Bioscience and Biotechnology, 5, 108-116. doi: 10.4236/abb.2014.52015.
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