On the Hyper Thermal Therapy of Tumor Tissues by Direct Laser Heating and Gold Nano Particles
Affiliation(s)
Macromolecular Research Laboratory, Department of Physics, Faculty of Sciences, University Abou Bekr Belkaid, Tlemcen, Algeria.
Macromolecular Research Laboratory, Department of Physics, Faculty of Sciences, University Abou Bekr Belkaid, Tlemcen, Algeria.
ABSTRACT
Hyper thermal therapy using lasers is
emerging as a new promising route for the cancer
treatment. The tumor can be directly heated by the
radiation or indirectly using gold nano particles based on plasmon
resonance phenolmenon. These two possibilities are explored here by solving the space and time
dependent bio-heat equation under different
conditions. The knowledge of temperature profiles in the tumor region helps to
bypass the painful placement of sensors for
monitoring tumor’s heating by the laser. Important properties which could be
useful for developing an efficient tumor therapy are introduced for the first
time. It is found that the effects of metabolism consist
essentially in a redefinition of the blood temperature which increases
proportional to the heat of metabolism. Blood perfusion in a given
tissue leads to a new characteristic length of order one or two centimeters and
a blood convection parameter typically of order 30 W·m-1·K-1. Effects of these parameters are
scrutinized within the resolution of the bio-heat equation
under a variety of conditions. In general, space modulations of the temperature
throughout biological tissues are weak but front kinetics are quite fast.
Specific examples show the way to monitor the temperature rise taking into
account the tumor’s nature and size.
Cite this paper
B. Fasla, R. Benmouna and M. Benmouna, "On the Hyper Thermal Therapy of Tumor Tissues by Direct Laser Heating and Gold Nano Particles," Journal of Biomaterials and Nanobiotechnology, Vol. 5 No. 1, 2014, pp. 44-51. doi: 10.4236/jbnb.2014.51007.
B. Fasla, R. Benmouna and M. Benmouna, "On the Hyper Thermal Therapy of Tumor Tissues by Direct Laser Heating and Gold Nano Particles," Journal of Biomaterials and Nanobiotechnology, Vol. 5 No. 1, 2014, pp. 44-51. doi: 10.4236/jbnb.2014.51007.
References
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http://dx.doi.org/10.1016/S0305-4179(02)00104-3 [23] J. Zhang, G. A. Sandison, J. Y. Murthy and L. Xu, “Numerical Simulation for Heat Transfer in Prostate Cancer Surgery,” Journal of Biomechanical Engineering-Transactions of the ASME, Vol. 127, 2005, pp. 279-294. [24] C. Diao, L. Zhu and H. Whang, “Cooling and Rewarming for Brain Ischemia or Injury: Theoretical Analysis,” Annals of Biomedical Engineering, Vol. 31, No. 3, 2003, pp. 346-353. [25] L. Zhu and C. Diao, “Theoretical Simulation of Temperature Distribution in the Brain during Hypothermic Treatment for Brain Injury,” Medical and Biological Engineering and Computing, Vol. 39, No. 6, 2001, pp. 681-687. [26] A. W. Guy, “Analysis of Electromagnetic Fields in Biological Tissues by Thermographic Studies on Equivalent Phantom Models,” IEEE Transactions on Microwave Theory and Techniques, Vol. 16, No. 2, 1971, pp. 205-214. [27] J. Liu, X. Chen and L. Xu, “New Thermal Wave Aspects on Burn Evaluation of Skin Subjected to Instantaneous Heating,” IEEE Transactions on Biomedical Engineering, Vol. 46, No. 4, 1999, p. 420. [28] F. Duck, “Physical Properties of Tissues,” Academic Press, London, 1990.
[1] J. M. Breasted, “Chirurgical Papyrus of Edwin Smith,” University of Chicago Press, Chicago, 1933. [2] L. Goldman and R. J. Rockwell Jr., “Lasers Systems and Their Applications in Medicine and Biology,” Advances in Biomedical Engineering and Medical Physics, Vol. 1, 1968, pp. 317-382. [3] G. Brix, S. Martin, H. Gesine and G. Jurger, “Estimation of Heat Transfer and Temperature Rise in Partial Body Regions during MR Procedures: An Analytical Approach with Respect to Safety Considerations,” Magnetic Resonance Imaging, Vol. 20, No. 1, 2002, pp. 65-76.
http://dx.doi.org/10.1016/S0730-725X(02)00483-6 [4] J. M. Dobson, “Radiation Therapy, Hyperthermia, Immuno-Therapy, in Manual of Small Animal Oncology,” In: R. A. S. White, Ed., British Small Animal Veterinary Association, Cheltenham, 1991, pp. 161-183. [5] A. P. Popov, A. V. Priezzhev and R. Myllyla, “Optimal Sizes of Gold Nanoparticles for Laser Treatment of Tumors,” 5th International Conference on Photonics and Imaging in Biology and Medicine, Proceedings of SPIE, Russia, 1 May 2007, Vol. 6534, 65343K-1-5. [6] T. Avedisian, R. E. Cavicchi, P. L. McEuen and X. Zhou, “Nanoparticles for Cancer Treatment: The Role of Heat Transfer,” Cornell University, Ithaca, 2007. [7] N. Harris, M. J. Ford and M. B. Cortie, “Optimization of Plasmonic Heating by Gold Nanospheres and Nanoshells,” The Journal of Physical Chemistry B, Vol. 110, No. 22, 2006, pp. 10701-10707.
http://dx.doi.org/10.1021/jp0606208 [8] J. Liu and M. Gu, “Gold Nanoparticle-Enhanced Cancer Photo-Thermal Therapy,” IEEE Journal, Vol. 16, No. 4, 2009, pp. 989-996. [9] X. Liu, M. C. Lloyd, I. V. Fedorenko, P. Bapat, T. Zhukov and Q. Huo, “Enhanced Imaging and Accelerated Photothermalysis of A549 Human Lung Cancer Cells by Gold Nanospheres,” Nanomedicine, Vol. 3, No. 5, 2008, pp. 617-626. http://dx.doi.org/10.2217/17435889.3.5.617 [10] I. H. El-Sayed, X. Huang and M. A. El-Sayed, “Selective Laser Photo-Thermal Therapy of Epithelial Carcinoma Using Anti-EGFR Antibody Conjugated Gold Nanoparticles,” Cancer Letters, Vol. 239, No. 1, 2006, pp. 129-135. http://dx.doi.org/10.1016/j.canlet.2005.07.035 [11] D. Pissuwan, S. M. Valenzuela and M. B. Cortie, “Therapeutic Possibilities of Plasmonicall Heated Gold Nanoparticles,” Trends in Biotechnology, Vol. 24, No. 2, 2006, pp. 62-67. http://dx.doi.org/10.1016/j.tibtech.2005.12.004 [12] X. Huang, P. K. Jain, I. H. El-Sayed and M. A. El-Sayed, “Plasmonic Photothermal Therapy (PPTT) Using Nanoparticles,” Lasers in Medical Science, Vol. 23, No. 3, 2008, pp. 217-228.
http://dx.doi.org/10.1007/s10103-007-0470-x [13] H. Pennes, “Analysis of Tissue and Arterial Blood Flow Temperatures in the Resting Human Forearm,” Journal of Applied Physiology, Vol. 1, No. 2, 1948, pp. 93-122. [14] Z. S. Deng and J. Liu, “Analytical Study on Bioheat Transfer Problems with Spatial or Transient Heating on Skin Surface or inside Biological Bodies,” Transactions of the ASME, Vol. 124, No. 6, 2002, pp. 638-649. [15] P. R. Sharma, S. Ali and V. K. Katiyar, “Transient Heat Transfer Analysis on Skin Surface and inside Biological Tissue,” Journal of Applied Mathematics and Mechanics, Vol. 5, No. 5, 2009, pp. 36-47. [16] J. C. Chato, “Fundamentals of Bioheat Transfer,” In: Gautherie, Ed., Thermal Dosimetry and Treatment Planning, Springer Verlag, Berlin, 1990, 1-56. [17] B. Erdmann, J. Lang and M. Seebass, “Adaptative Solution of Nonlinear Parabolic Equations with Application to Hyperthermia Treatments,” Technical Report, Konrad-Zuse-Zentrum fur Informationstechnik, Berlin, 1997. [18] T. C. Shih, P. Yuan, W. L. Lin and H. S. Kou, “Analytical Analysis of the Pennes Bioheat Transfer Equation with Sinusoidal Heat Flux Condition on Skin Surface,” Medical Engineering & Physics, Vol. 29, No. 9, 2007, pp. 946-953. http://dx.doi.org/10.1016/j.medengphy.2006.10.008 [19] M. Abramowitz and I. A. Stegun, “Handbook of Mathematical Functions,” Dover Publishing Inc., New York, 1970. [20] B. Fasla, R. Benmouna and M. Benmouna, “Modeling of Tumor’S Tissue Heating by Nano Particles,” Journal of Applied Physics, Vol. 108, No. 12, 2010, Article ID: 124703. http://dx.doi.org/10.1063/1.3525089 [21] V. L. Dragun, S. M. Damilove, Y. Tret and S. A. Gubarev, “Simulation of Reacting of Biological Tissues in the Process of Ultrahigh Frequency Therapy,” Journal of Engineering Physics and Thermophysics, Vol. 78, No. 1, 2005, pp. 109-114. [22] S. C. Tiang, H. J. Ma, H. J. Li and X. Zhang, “Effect of Thermal Properties and Geometrical Dimensions on Skin Burn Injuries,” Burns, Vol. 28, No. 8, 2002, pp. 713-717.
http://dx.doi.org/10.1016/S0305-4179(02)00104-3 [23] J. Zhang, G. A. Sandison, J. Y. Murthy and L. Xu, “Numerical Simulation for Heat Transfer in Prostate Cancer Surgery,” Journal of Biomechanical Engineering-Transactions of the ASME, Vol. 127, 2005, pp. 279-294. [24] C. Diao, L. Zhu and H. Whang, “Cooling and Rewarming for Brain Ischemia or Injury: Theoretical Analysis,” Annals of Biomedical Engineering, Vol. 31, No. 3, 2003, pp. 346-353. [25] L. Zhu and C. Diao, “Theoretical Simulation of Temperature Distribution in the Brain during Hypothermic Treatment for Brain Injury,” Medical and Biological Engineering and Computing, Vol. 39, No. 6, 2001, pp. 681-687. [26] A. W. Guy, “Analysis of Electromagnetic Fields in Biological Tissues by Thermographic Studies on Equivalent Phantom Models,” IEEE Transactions on Microwave Theory and Techniques, Vol. 16, No. 2, 1971, pp. 205-214. [27] J. Liu, X. Chen and L. Xu, “New Thermal Wave Aspects on Burn Evaluation of Skin Subjected to Instantaneous Heating,” IEEE Transactions on Biomedical Engineering, Vol. 46, No. 4, 1999, p. 420. [28] F. Duck, “Physical Properties of Tissues,” Academic Press, London, 1990.