JBNB  Vol.5 No.1 , January 2014
Single Nucleotide Polymorphisms and Haplotypes in Vascular Endothelial Growth Factor Gene and Residual Ridge Resorption of Mandible in Korean Population
Abstract: The tooth extraction is a routine surgical procedure in the dental treatment where the healing process results in a saddle-shaped residual ridge in the edentulous jaw. There are substantial differences among individuals in the end result. In some cases, there is excessive bone atrophy, which complicates the dental restorative treatment. The alveolar ridge receives the mechanical load continuously from the periodontal ligament connected to the teeth and it diminishes dramatically as a consequence of dental extraction; thus it is believed the continuing pattern of the alveolar bone resorption is related to this change. The reduced partial pressure of oxygen is the most prominent event from the reduced mechanical load. Vascular Endothelial Growth Factor (VEGF), regulated by HIF-1, reported close association with angiogenesis and bone turn over, where partial oxygen pressure has changed. Therefore the genetic association between Single Nucleotide Polymorphsim (SNP) of VEGF gene and RRR was investigated. 120 subjects (70.93 ± 9.28 years) which were treated at Dental clinic of Yonsei University with edentulous mandible were recruited. Mandibular bone height was measured following the protocol of the American College of Prosthodontists. Three variants, rs1570360, rs25648, and rs3025039 in VEGF from previous study, were used as tag-SNPs and genotyping for the study. Student’s t-test and ANOVA were used for statistical analysis. There was a notable association with rs1570360 (P = 0.051) in dominant group and haplotype A-C-C showed a statistically significant association with RRR in dominant group (P = 0.042). Results of this study may be useful in developing novel genetic diagnostic tests and identifying Koreans susceptible to developing severe RRR after dental extraction.
Cite this paper: J. Song and J. Lee, "Single Nucleotide Polymorphisms and Haplotypes in Vascular Endothelial Growth Factor Gene and Residual Ridge Resorption of Mandible in Korean Population," Journal of Biomaterials and Nanobiotechnology, Vol. 5 No. 1, 2014, pp. 39-43. doi: 10.4236/jbnb.2014.51006.

[1]   Y. Kim, Y. J. Nam and C. Lee, “Haplotype Analysis of Single Nucleotide Polymorphisms in VEGF Gene for Vascular Dementia,” American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 141B, No. 4, 2006, pp. 332-335.

[2]   H. Devlin and M. W. Ferguson, “Alveolar Ridge Resorption and Mandibular Atrophy. A Review of the Role of Local and Systemic Factors,” British Dental Journal, Vol. 170, No. 3, 1991, pp. 101-104.

[3]   T. Haraldson, U. L. F. Karlsson and G. E. Carlsson, “Bite Force and Oral Function in Complete Denture Wearers,” Journal of Oral Rehabilitation, Vol. 6, No. 1, 1979, pp. 41-48.

[4]   A. Tallgren, “The Continuing Reduction of the Residual Alveolar Ridges in Complete Denture Wearers: A MixedLongitudinal Study Covering 25 Years,” The Journal of Prosthetic Dentistry, Vol. 89, No. 5, 2003, pp. 427-435.

[5]   A. Tallgren, B. R. Lang, G. F. Walker and M. M. Ash, “Roentgen Cephalometric Analysis of Ridge Resorption and Changes in Jaw and Occlusal Relationships in Immediate Complete Denture Wearers,” Journal of Oral Rehabilitation, Vol. 7, No. 1, 1980, pp. 77-94.

[6]   S. Hansson and A. Halldin, “Alveolar Ridge Resorption after Tooth Extraction: A Consequence of a Fundamental Principle of Bone Physiology,” Journal of Dental Biomechanics, Vol. 3, 2012.

[7]   J.-J. Kim, H.-C. Shon, J.-S. Chang, J.-H. Kim, K.-S. Lee and S.-W. Kim, “HIF-1 Alpha and VEGF Expression in Fracture Healing,” The Journal of the Korean Orthopaedic Association, Vol. 43, No. 4, 2008, pp. 479-487.

[8]   J. W. Lee, S. H. Bae, J. W. Jeong, S. H. Kim and K. W. Kim, “Hypoxia-Inducible Factor (HIF-1) Alpha: Its Protein Stability and Biological Functions,” Experimental & Molecular Medicine, Vol. 36, No. 1, 2004, pp. 1-12.

[9]   N. Ferrara, H. P. Gerber and J. LeCouter, “The Biology of VEGF and Its Receptors,” Nature Medicine, Vol. 9, No. 6, 2003, pp. 669-676.

[10]   J. H. Kim, M. Y. Oh, J. Paek and J. Lee, “Association between FGFR1OP2/wit3.0 Polymorphisms and Residual Ridge Resorption of Mandible in Korean Population,” PLoS ONE, Vol. 7, No. 8, 2012, Article ID: e42734.

[11]   M. S. Rogers and R. J. D’Amato, “The Effect of Genetic Diversity on Angiogenesis,” Experimental Cell Research, Vol. 312, No. 5, 2006, pp. 561-574.

[12]   M. GarcÄa-Closas, N. Malats, F. X. Real, M. Yeager, R. Welch, D. Silverman, et al., “Large-Scale Evaluation of Candidate Genes Identifies Associations between VEGF Polymorphisms and Bladder Cancer Risk,” PLOS Genetics, Vol. 3, No. 2, 2007, Article ID: e29.