The liver, as the central metabolic organ, plays an important role in metabolism of carbohydrates, lipids and proteins. In the environment, there are many hepatotoxic xenobiotics. CCl4 is a free radical toxic for organelles of hepatocytes. The presented work was studying the character of ultrastructural changes in CCl4-intoxicated hepatocytes as well as the tissue after treatment by grape seed extract (GSE), α-tocopherol (α-T). As a result of cell bioremediation effect and reactions against corruptive factors, the liver has a high regeneration ability.
Cite this paper
Hovnanyan, K. , Mamikonyan, V. , Margaryan, A. , Sargsyan, K. , Hovnanyan, M. , Karagyozyan, M. and Karageuzyan, K. (2014) Antioxidants as effective remedies at hepatotoxic action of carbon tetrachloride. Journal of Biophysical Chemistry
, 1-4. doi: 10.4236/jbpc.2014.51001
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