CRCM  Vol.3 No.1 , January 2014
Iatrogenic calcinosis cutis in a child affected by Acute Lymphoblastic Leukemia
Abstract: Iatrogenic calcinosis cutis is a rare disorder that can be due to the intravenous administration of calcium or phosphate-containing infusions such as calcium gluconate or calcium chloride with extravasation. Fortunately, the course of calcinosis cutis is benign in immunocompetent children. The treatment remains supportive therapy. After about 6 months, there is no evidence of tissue calcification. We describe a 4-year-old girl with Acute Lymphoblastic Leukemia (ALL) who developed severe calcinosis cutis in the left humerus after extravasation of calcium gluconate during the treatment for the tumor-lysissyndrome-related hypocalcaemia. Surgical debridement and local wound care were not successful, and so a temporary suspension of chemotherapy was necessary to achieve complete healing of the lesion. Notwithstanding this complication, her ALL is in complete hematological remission after 8 months from the diagnosis. No functional or sensitive impairment due to the cutis has persisted.
Cite this paper: Perillo, T. , Arcamone, G. , Bonamonte, D. , Pascone, M. and Santoro, N. (2014) Iatrogenic calcinosis cutis in a child affected by Acute Lymphoblastic Leukemia. Case Reports in Clinical Medicine, 3, 13-17. doi: 10.4236/crcm.2014.31004.

[1]   Angel, F.-F. (2011) Calcinosis cutis: Critical review. Acta Dermatovenerologica Croatica, 19, 43-50.

[2]   Rodriguez-Cano, L., Garcia-Patos, V., Creus, M., Bastida, P., Ortega, J.J. and Castells, A. (1996) Childhood calcinosis cutis. Pediatric Dermatology, 13, 114-117.

[3]   Sell, E.J., Hansen, R.C. and Struck-Pierce, S. (1980) Calcified nodules on the heel: A complication of neonatal intensive care. Journal of Pediatrics, 96, 473-475.

[4]   Leung, A. (1985) Calcification following heel sticks. Journal of Pediatrics, 106, 168.

[5]   Cambiaghi, S., Restano, L. and Imondi, D. (1997) Calcified nodule of the heel. Pediatric Dermatology, 14, 494.

[6]   Williamson, D. and Holt, P.J. (2001) Calcified cutaneous nodules on the heels of children: a complication of heel sticks as a neonate. Pediatric Dermatology, 18, 138-140.

[7]   Rho, N.K., Youn, S.J., Park, H.S., Kim, W.S. and Lee, E.S. (2003) Calcified nodule on the heel of a child following a single heel stick in the neonatal period. Clinical and Experimental Dermatology, 28, 502-503.

[8]   Reiter, N., El-Shabrawi, L., Leinweber, B., Berghold, A. and Aberer, E. (2011) Calcinosis cutis. Treatment options. Journal of American Academy of Dermatology, 65, 15-22.

[9]   Lee, F.A. and Gwinn, J.L. (1975) Roentgen patterns of extravasation of calcium gluconate in the tissues of the neonate. Journal of Pediatrics, 86, 598-601.

[10]   Lestringant, G.G., Masouyè, I., El-Hayek, M., Girardet, C., Revesz, T. and Frossard, P.M. (2000) Diffuse calcinosis cutis in a patient with congenital leukemia and leukemia cutis. Dermatology, 200, 147-150.

[11]   Moss, J., Syrengelas, A., Antaya, R. and Lazova, R. (2006) Calcinosis cutis: A complication of intravenous administration of calcium gluconate. Journal of Cutaneous Pathology, 33, 60-62.

[12]   Raffaella, C., Annapaola, C. and Tullio, I. (2009) Successful treatment of severe iatrogenic calcinosis cutis with intravenous sodium thiosulfate in a child affected by T-acute lymphoblastic leukemia. Pediatric Dermatology, 26, 311-315.