CRCM  Vol.3 No.1 , January 2014
A case of severe pneumonia caused by multiple bacterial organisms following type B influenza virus infection
Abstract: A 50-year old woman, without any underlying disease, presented with pneumonia after experiencing flu-like symptoms. Streptococcus pneumoniae was identified on admission through blood culture and urine antigen tests. Staphylococcus aureus and Streptococcus pneumoniae were present in the sputum culture. Computed tomography showed cavity development in the consolidation areas, typical of staphylococcal pneumonia. The patient was intubated and received mechanical ventilation as respiratory failure progressed. She exhibited improvement following antibiotic therapy. The change in type B influenza virus serum titer confirmed that this was a unique case of severe pneumonia caused by multiple bacterial organisms following type B influenza virus infection.
Cite this paper: Sato, M. , Tomioka, E. , Horio, J. , Chubachi, S. , Matsuzaki, T. and Terashima, T. (2014) A case of severe pneumonia caused by multiple bacterial organisms following type B influenza virus infection. Case Reports in Clinical Medicine, 3, 1-5. doi: 10.4236/crcm.2014.31001.

[1]   Louria, D.B., Blumenfeld, H.L, Ellis, J.T., Kilbourne, E.D. and Rogers, D.E. (1959) Studies of the pandemic of 1957-1958. II. Pulmonary complications of influenza. Journal of Clinical Investigation, 38, 213-265.

[2]   Brundage, J.F. (2006) Interactions between influenza and bacterial respiratory pathogens: Implications for pandemic preparedness. Lancet Infectious Diseases, 6, 303-312.

[3]   Morens, D.M., Taubenberger, J.K. and Fauci, A.S. (2008) Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: Implications for pandemic influenza preparedness. The Journal of Infectious Diseases, 198, 962-970.

[4]   Metersky, M.L., Masterton, R.G., Lode, H., File, T.M. and Babinchak, T. (2012) Epidemiology, microbiology and treatment considerations for bacterial pneumonia complicating influenza. International Journal of Infectious Diseases, 16, e321-e331.

[5]   Glezen, W.P. (1982) Serious morbidity and mortality associated with influenza epidemics. Epidemiologic Reviews, 4, 25-44.

[6]   Serfung, R.E., Sherman, I.L. and Houseworth, W.J. (1967) Excess pneumonia-influenza mortality by age and sex in three major influenza A2 epidemics, United States, 1957-58, 1960 and 1963. American Journal of Epidemiology, 86, 433-441.

[7]   Fine, M.J., Smith, M.A., Carson, C.A., et al. (1996) Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. JAMA, 274, 134-141.

[8]   Scheiblauer, H., Reinacher, M., Tashiro, M. and Rott, R. (1992) Interactions between bacteria and influenza A virus in the development of influenza pneumonia. The Journal of Infectious Diseases, 166, 783-791.

[9]   Thompson, W.W., Shay, D.K., Weintraub, E., et al. (2004) Influenza-associated hospitalizations in the United States. Journal of the American Medical Informatics Association, 292, 1333-1340.

[10]   Bisno, A.L., Griffin, J.P., Van Epps, K.A., Niell, H.B. and Rytel, M.W. (1971) Pneumonia and Hong Kong influenza: A prospective study of the 1968-1969 epidemic. The American Journal of the Medical Sciences, 261, 251-263.

[11]   Nichol, K.L., Wuorenma, J. and Von Sternberg, T. (1998) Benefits of influenza vaccination for low-, intermediateand high-risk senior citizens. Archives of Internal Medicine, 158, 1769-1776.

[12]   Lindsay Jr., M.I., Herrmann Jr., E.C., Morrow Jr., G.W. and Brown Jr., A.L. (1970) Hong Kong influenza: Clinical, microbiologic and pathologic features in 127 cases. Journal of the American Medical Informatics Association, 214, 1825-1832.

[13]   Lim, W.S., Van Der Eerden, M.M., Laing, R., et al. (2003) Defining community acquired pneumonia severity on presentation to hospital: An international derivation and validation study. Thorax, 58, 377-382.

[14]   Mandell, L.A., Wunderink, R.G., Anzueto A., et al. (2007) Infectious diseases society of America/American thoracic society consensus guidelines on the management of community-acquired pneumonia in adults. Clinical Infectious Diseases, 44, S27-S72.

[15]   Gutiérrez-Pizarraya, A., Pérez-Romero, P., Alvarez, R., et al. (2012) Unexpected severity of cases of influenza B infection in patients that required hospitalization during the first postpandemic wave. Journal of Infection, 65, 423-430.

[16]   Leatherman, J.W., Iber, C. and Davies, S.F. (1984) Cavitation in bacteremic pneumococcal pneumonia. Causal role of mixed infection with anaerobic bacteria. American Review of Respiratory Disease, 129, 317-321.

[17]   Pande, A., Nasir, S., Rueda, A.M., et al. (2012) The incidence of necrotizing changes in adults with pneumococcal pneumonia. Clinical Infectious Diseases, 54, 10-16.

[18]   Macfarlane, J. and Rose, D. (1996) Radiographic features of staphylococcal pneumonia in adults and children. Thorax, 51, 539-540.

[19]   Kaye, M.G., Fox, M.J., Bartlett, J.G., Braman, S.S. and Glassroth, J. (1990) The clinical spectrum of staphylococcus aureus pulmonary infection. Chest, 97, 788-792.

[20]   Seki, M., Kosai, K., Yanagihara, K., et al. (2007) Disease severity in patients with simultaneous influenza and bacterial pneumonia. Internal Medicine, 46, 953-958.

[21]   Joseph, C., Togawa, Y. and Shindo N. (2013) Bacterial and viral infections associated with influenza. Influenza and Other Respiratory Viruses, 7, 105-113.

[22]   Wie, S., So, B.H., Song, J.Y., et al. (2013) A comparison of the clinical and epidemiological characteristics of adult patients with laboratory-confirmed influenza A or B during the 2011-2012 influenza season in Korea: A multi-center study. PLoS One, 8, Article ID: e62685.

[23]   Scaber, J., Saeed, S., Ihekweazu, C., Efstratiou, A., McCarthy, N. and O’Moore, E. (2011) Group a streptococcal infections during the seasonal influenza outbreak 2010/11 in South East England. Eurosurveillance, 16, pii:19780.

[24]   Aebi, T., Weisser, M., Bucher, E., Hirsch, H.H., Marsch, S. and Siegemund, M. (2010) Co-infection of influenza B and streptococci causing severe pneumonia and septic shock in healthy women. BMC Infectious Diseases, 10, 308.