Histologic Types of Chest Wall Tumors—Nine Years’ Single Center Experience
Author(s)
Zohreh Mohammadtaheri,
Atosa Dorudinia*,
Abolghasem Daneshvar,
Pegah Akhavan Azar,
Foruzan Mohammadi
Affiliation(s)
Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
ABSTRACT
Background: Chest wall tumors are rare and mostly malignant. More than half of the malignancies are primary and the remainder are metastatic. Many studies have reported that metastatic lesions occur with about the same frequency as primary tumor. We evaluate common histological types of chest wall tumors in a tertiary center for respiratory and thoracic diseases (National Research Institute of Tuberculosis and Lung Disease). Method: We performed a retrospective study of chest wall tumors at National Research Institute of Tuberculosis and Lung Disease (NRITLD) from April 2001 to March 2010. The pathology slides of patients were retrieved from the pathology archive of NRITLD and reviewed by two pathologists. The lesions were classified as primary or metastatic according to the relevant clinical data and imaging findings. Result: A total of 124 chest wall tumors were identified in patients with a mean age of 47.7 years (range 4-90 years). The male/female ratio was 2:1. The most commonly affected side was the right (42.7%). There were 105 malignant tumors (84.7%), out of which 49 (46.2%) were primary and 57 (53.8%) were metastatic in origin. The majority of the metastatic lesions were epithelial tumors (36/57) (63.1%). The metastatic origin was clear in 51 cases, mostly arising from the lungs (35.7%). The most common types of primary chest wall tumors were primitive neuroectodermal tumor (15/49, 30.6%), chondrosarcoma (7/49, 14.3%), and malignant fibrous histiocytoma, undifferentiated pleomorphic sarcoma (5/49, 10.2%). The most common benign tumor was lipoma (5/18, 35.7%). Conclusion: Most common tumors of chest wall in this study were malignant, mostly metastatic epithelial neoplasms.
Cite this paper
Z. Mohammadtaheri, A. Dorudinia, A. Daneshvar, P. Azar and F. Mohammadi, "Histologic Types of Chest Wall Tumors—Nine Years’ Single Center Experience," Open Journal of Pathology, Vol. 4 No. 1, 2014, pp. 13-19. doi: 10.4236/ojpathology.2014.41003.
Z. Mohammadtaheri, A. Dorudinia, A. Daneshvar, P. Azar and F. Mohammadi, "Histologic Types of Chest Wall Tumors—Nine Years’ Single Center Experience," Open Journal of Pathology, Vol. 4 No. 1, 2014, pp. 13-19. doi: 10.4236/ojpathology.2014.41003.
References
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http://dx.doi.org/10.1148/rg.265065084 [25] B. A. Özuslu, O. Genç, S. Gürkök and K. Balkanli, “Chest Wall Tumors,” Asian Cardiovascular & Thoracic Annals, Vol. 6, No. 3, 1998, pp. 212-215.
http://dx.doi.org/10.1177/021849239800600314 [26] P. K. Hsu, H. S. Hsu, A. F. Y. Li, et al., “Non-Hodgkin’s Lymphoma Presenting as a Large Chest Wall Mass,” The Annals of Thoracic Surgery, Vol. 81, No. 4, 2006, pp. 1214-1219.
http://dx.doi.org/10.1016/j.athoracsur.2005.11.044 [27] H. Saurai, M. Kaji, K. Yamazaki, et al., “Intrathoracic Lipomas: Their Clinicopathological Behavior Are Not as Straight Forward as Expected,” The Annals of Thoracic Surgery, Vol. 86, No. 1, 2008, pp. 261-265.
http://dx.doi.org/10.1016/j.athoracsur.2008.03.052 [28] A. F. Hass, H. S. Feromer and G. M. Brica, “Spindle Cell Lipoma of the Scalp. Case Report and Review,” Dermatologic Surgery, Vol. 25, No. 1, 1999, pp. 68-71.
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http://dx.doi.org/10.1016/j.athoracsur.2003.09.022
[1] F. L. Penfield, J. Somers and A. C. Templeton, “Cheat Wall Tumors,” Current Problems in Surgery, Vol. 32, No. 8, 1995, pp. 663-747. [2] P. K. Hsu, H. S. Hsu, H. C. Lee, et al., “Management of Primary Chest Wall Tumors: 14 Years’ Clinical Experience,” Journal of the Chinese Medical Association, Vol. 69, No. 8, 2006, pp. 377-382.
http://dx.doi.org/10.1016/S1726-4901(09)70276-X [3] U. Tateishi, G. W. Gladish, M. Kusumoto, et al., “Chest Wall Tumors: Radiologic Findings and Pathologic Correlation. Part 1. Benign Tumors,” Radiographics, Vol. 23, Vol. 6, 2003, pp. 1477-1490. [4] U. Tateishi, G. W. Gladish, M. Kusumoto, et al., “Chest Wall Tumors: Radiologic Findings and Pathologic Correlation. Part 2. Malignant Tumors,” Radiographics, Vol. 23, No. 6, 2003, pp. 1491-1508.
http://dx.doi.org/10.1148/rg.236015527 [5] G. M. Graeber, R. J. Snyder, A. W. Fleming, et al., “Initial and Long-Term Results in the Management of Primary Chest Wall Neoplasms,” The Annals of Thoracic Surgery, Vol. 34, No. 6, 1982, pp. 664-673.
http://dx.doi.org/10.1016/S0003-4975(10)60906-X [6] K. Athanassiadi, G. Kalavrouziotis, D. Rondogianni, et al., “Primary Chest Wall Tumors: Early and Long-Term Results of Surgical Treatment,” European Journal Cardio-Thoracic Surgery, Vol. 19, No. 5, 2001, pp. 589-593.
http://dx.doi.org/10.1016/S1010-7940(01)00655-8 [7] M. Incarbone and U. Pastorino, “Surgical Treatment of Chest Wall Tumors,” World Journal of Surgery, Vol. 25, No. 2, 2001, pp. 218-230.
http://dx.doi.org/10.1007/s002680020022 [8] S. K. Chowdhury, K. S. V. K. Subbarao, M. Nachiappan and K. Agrawal, “Primary Neoplasm of the Chest Wall: Surgical Management,” Asian Cardiovascular and Thoracic Annals, Vol. 8, No. 3, 2000, pp. 249-252.
http://dx.doi.org/10.1177/021849230000800313 [9] K. Athanassiadi, G. Kalavrouziotis, D. Rondogianni, et al., “Primary Chest Wall Tumors: Early and Long-Term Results of Surgical Treatment,” European Journal Cardio-Thoracic Surgery, Vol. 19, No. 5, 2001, pp. 589-593.
http://dx.doi.org/10.1016/S1010-7940(01)00655-8 [10] A. Shah and T. A. D’Amico, “Primary Chest Wall Tumors,” Journal of the American College of Surgeons, Vol. 210, No. 3, 2010, pp. 360-366. [11] P. O’Sullivan, H. O’Dwyer, J. Flint, et al., “Malignant Chest Wall Neoplasms of Bone and Cartilage: A Pictorial Review of CT and MR Findings,” The British Journal of Radiology, Vol. 80, No. 956, 2007, pp. 678-684.
http://dx.doi.org/10.1259/bjr/82228585 [12] S. W. Weiss and J. R. Goldblum, “Enzinger and Weiss’s Soft Tissue Tumors,” Mosby-Harcort Press, Philadelphia, 2008. [13] H. D. Dorfman and B. Czerniak, “Bone Tumors,” Mosby Press, Clay County, 1998. [14] N. Yoshida, N. Miyanari, Y. Yamamoto and H. Egami, “Successful Treatment of Malignant Fibrous Histiocytoma Originating in the Chest Wall: Report of a Case,” Surgery Today, Vol. 36, No. 8, 2006, pp. 714-721.
http://dx.doi.org/10.1007/s00595-004-3229-z [15] O. M. AI-Agha and A. A. Igbokwe, “Malignant Fibrous Histiocytoma: Between the Past and the Present,” Archives of Pathology & Laboratory Medicine, Vol. 132, No. 6, 2008, pp. 1030-1035. [16] J. L. Gross, R. N. Younes, F. J. Haddad, et al., “Soft Tissue Sarcomas of the Chest Wall: Prognostic Factors,” Chest, Vol. 127, No. 3, 2005, pp. 902-908.
http://dx.doi.org/10.1378/chest.127.3.902 [17] R. C. Shamberger, H. E. Grier, H. J. Weinstein, et al., “Chest Wall Tumors in Infancy and Childhood,” Cancer, Vol. 63, No. 4, 1989, pp. 774-785.
http://dx.doi.org/10.1002/1097-0142(19890215)63:4<774::AID-CNCR2820630429>3.0.CO;2-2 [18] M. S. Gordon, S. I. Hajdu, M. S. Bains and M. E. Burt, “Soft Tissue Sarcomas of the Chest Wall: Results of Surgical Resection,” The Journal of Thoracic and Cardiovascular Surgery, Vol. 101, No. 5, 1991, pp. 843-854. [19] J. M. Mira and R. H. Gold, “Bone Tumors. Clinical, Radiologic and Pathologic Correlations,” Mosby, Philadelphia, 1989. [20] J. Matsumoto, H. Sugiura, T. Morikawa, et al., “A Case of Primary Leiomyosarcoma of the Chest Wall Successfully Resected under the Video-Assisted Thoracoscopic Approach,” Annals of Thoraacic and Cardiovascular Surgery, Vol. 7, No. 6, 2001, pp. 368-370. [21] G. Farshid, M. Pradhan, J. Goldblum, et al., “Leiomyosarcomas of Somatic Soft Tissues: A Tumor of Vascular Origin with Multivariate Analysis of Outcome in 42 Cases,” American Journal of Surgical Pathology, Vol. 26, No. 1, 2002, pp. 14-24.
http://dx.doi.org/10.1097/00000478-200201000-00002 [22] Y. Namba, A. Kawai, N. Naito, et al., “Intraarticular Synovial Sarcoma Confirmed by SYT-SSX Fusion Transcript,” Clinical Orthopaedics and Related Research, Vol. 2, No. 395, 2002, pp. 221-226. [23] J. F. Fetch and J. M. Meis, “Synovial Sarcoma of the Abdominal Wall,” Cancer, Vol. 72, No. 2, 1993, pp. 469-477.
http://dx.doi.org/10.1002/1097-0142(19930715)72:2<469::AID-CNCR2820720224>3.0.CO;2-Q [24] M. D. Murphey, M. S. Gibson, B. T. Jennings, et al., “From the Archives of the AFIP Imaging of Synovial Sarcoma with Radiologic-Pathologic Correlation,” RadioGraphics, Vol. 26, No. 5, 2006, pp. 1543-1565.
http://dx.doi.org/10.1148/rg.265065084 [25] B. A. Özuslu, O. Genç, S. Gürkök and K. Balkanli, “Chest Wall Tumors,” Asian Cardiovascular & Thoracic Annals, Vol. 6, No. 3, 1998, pp. 212-215.
http://dx.doi.org/10.1177/021849239800600314 [26] P. K. Hsu, H. S. Hsu, A. F. Y. Li, et al., “Non-Hodgkin’s Lymphoma Presenting as a Large Chest Wall Mass,” The Annals of Thoracic Surgery, Vol. 81, No. 4, 2006, pp. 1214-1219.
http://dx.doi.org/10.1016/j.athoracsur.2005.11.044 [27] H. Saurai, M. Kaji, K. Yamazaki, et al., “Intrathoracic Lipomas: Their Clinicopathological Behavior Are Not as Straight Forward as Expected,” The Annals of Thoracic Surgery, Vol. 86, No. 1, 2008, pp. 261-265.
http://dx.doi.org/10.1016/j.athoracsur.2008.03.052 [28] A. F. Hass, H. S. Feromer and G. M. Brica, “Spindle Cell Lipoma of the Scalp. Case Report and Review,” Dermatologic Surgery, Vol. 25, No. 1, 1999, pp. 68-71.
http://dx.doi.org/10.1046/j.1524-4725.1999.08038.x [29] J. H. McClenathan and R. J. Bloom, “Peripheral Tumors of the Intercostal Nerves,” The Annals of Thoracic Surgery, Vol. 78, No. 2, 2004, pp. 713-714.
http://dx.doi.org/10.1016/j.athoracsur.2003.09.022