Neutropenia in a child presents a wide differential diagnosis, spanning the
spectrum of benign disorders (such as congenital neutropenia, cyclic
neutropenia, etc.) to malignant processes (such as myelodysplasia or acute
leukemia). The morphologic findings in the bone marrow of a patient with neutropenia
may show considerable overlap with those seen in hematopoietic malignancies. We
present herein a case that demonstrates this overlap and discuss features that
can help in avoiding diagnostic pitfalls.
Cite this paper
R. Sharma, J. Hemminger and S. Kahwash, "Clinical Pathological Correlation Quiz: A 7-Month-Old Girl with Congenital Neutropenia and Increased Bone Morrow “Blasts”," Open Journal of Pathology
, Vol. 4 No. 1, 2014, pp. 1-4. doi: 10.4236/ojpathology.2014.41001
 L. A. Boxer, “How to Approach Neutropenia,” Hematology: The Education Program of the American Society of Hematology, Vol. 2012, No. 1, 2012, pp. 174-182.
 K. Welte, C. Zeidler and D. C. Dale, “Severe Congenital Neutropenia,” Seminars in Hematology, Vol. 43, No. 3, 2006, pp. 189-195. http://dx.doi.org/10.1053/j.seminhematol.2006.04.004
 K. Boztug and C. Klein, “Novel Genetic Etiologies of Severe Congenital Neutropenia,” Current Opinion in Immunology, Vol. 21, No. 5, 2009, pp. 472-480. http://dx.doi.org/10.1016/j.coi.2009.09.003
 M. S. Horwitz, S. J. Corey, H. L. Grimes and T. Tidwell, “ELANE Mutations in Cyclic and Severe Congenital Neutropenia: Genetics and Pathophysiology,” Hematology/Oncology Clinics of North America, Vol. 27, No. 1, 2013, pp. 19-41. http://dx.doi.org/10.1016/j.hoc.2012.10.004
 M. Shiohara, T. Shigemura, S. Saito, M. Tanaka, R. Yanagisawa, K. Sakashita, H. Asada, E. Ishii, K. Koike, M. Chin, M. Kobayashi and K. Koike, “Ela2 Mutations and Clinical Manifestations in Familial Congenital Neutropenia,” Journal of Pediatric Hematology/Oncology, Vol. 31, No. 5, 2009, pp. 319-324. http://dx.doi.org/10.1097/MPH.0b013e3181984dbe
 C. A. Tschan, C. Pilz, C. Zeidler, K. Welte and M. Germeshausen, “Time Course of Increasing Numbers of Mutations in the Granulocyte Colony-Stimulating Factor Receptor Gene in a Patient with Congenital Neutropenia Who Developed Leukemia,” Blood, Vol. 97, No. 6, 2001, pp. 1882-1884. http://dx.doi.org/10.1182/blood.V97.6.1882
 J. A. Connelly, S. W. Choi and J. E. Levine, “Hematopoietic Stem Cell Transplantation for Severe Congenital Neutropenia,” Current Opinion in Hematology, Vol. 19, No. 1, 2012, pp. 44-51. http://dx.doi.org/10.1097/MOH.0b013e32834da96e
 K. Welte and L. Boxer, “Severe Chronic Neutropenia: Pathophysiology and Therapy,” Seminars in Hematology, Vol. 34, No. 4, 1997, pp. 267-278.
 N. Klupp, I. Simonitsch, C. Mannhalter and G. Amann, “Emergence of an Unusual Bone Marrow Precursor B- Cell Population in Fatal Shwachman-Diamond Syndrome,” Archives of Pathology & Laboratory Medicine, Vol. 124, No. 9, 2000, pp. 1379-1381.