IJCM  Vol.4 No.12 A , December 2013
IgG4-Related Disease Presenting as a Soft Tissue Tumor Affecting Skeletal Muscle: A Case Report

Background: IgG4-related disease is a systemic lymphoproliferative syndrome that shows IgG4-producing plasma cell expansion in affected organs with fibrotic or sclerotic changes. The lacrimal glands, salivary glands and pancreas are typically affected. We report a case of IgG4-related disease presenting a soft tissue tumor affecting skeletal muscle. Case Report: A 32-year-old man presented a soft tissue mass in his left arm. Magnetic resonance imaging revealed a spindle like, peripheral mass, in the lateral head of the triceps of his left arm. Tru-Cut Biopsy provided the diagnosis of IgG4-related disease affecting skeletal muscle. Glucocorticoid treatment was effective. Conclusion: To our knowledge, this is the first reported case of IgG4-related disease affecting skeletal muscle and presenting a soft tissue mass.

Cite this paper: D. Martínez, F. Oliva, M. Fernández Aceñero, E. Moyer and J. Arranz Cozar, "IgG4-Related Disease Presenting as a Soft Tissue Tumor Affecting Skeletal Muscle: A Case Report," International Journal of Clinical Medicine, Vol. 4 No. 12, 2013, pp. 1-4. doi: 10.4236/ijcm.2013.412A1001.

[1]   T. A. Damron, “Oncology and Basic Science,” Lippincott Williams & Wilkins, Philadelphia, 2008.

[2]   J. H. Stone, Y. Zen and V. Deshpande, “Mechanisms of disease: IgG4-related disease,” The New England Journal of Medicine, Vol. 366, No. 6, 2012, pp. 539-551.

[3]   H. Umehara, K. Okazaki, Y. Masaki, et al., “Comprehensive Diagnostic Criteria for IgG4-Related Disease (IgG4RD), 2011,” Modern Rheumatology, Vol. 22, No. 1, 2012, pp. 21-30.

[4]   M. Yasufumi, K. Nozomu and U. Hisanori, “IgG4-Related Disease: A Novel Lymphoproliferative Disorder Discovered and Established in Japan in the 21st Century,” Journal of Clinical and Experimental Hematopathology, Vol. 51, No. 1, 2011, pp. 13-20.

[5]   H. M. Moutsopoulos, G. E. Fragoulis and J. H. Stone, “Overview of IgG4-Related Disease,” 2013.

[6]   M. N. Carruthers, J. H. Stone and A. Khosroshahi, “The Latest on IgG4-RD: A Rapidly Emerging Disease,” Current Opinion in Rheumatology, Vol. 24, No. 1, 2012, pp. 60-69.