The title of this little assay coins three new words: Pre-Chelates, Post-Adducts and Implexes.
These, very daring new excursions into the scientific English language,
come from the developments of Quelamycin and Sodium L-Thioproline, through our
different group studies arriving to cancer reversal by a dual strategy. It is
enough to read all our published materials, cites and related papers, dealing
more or less with the chemistry and possible mechanism of action of these compounds,
to gather somewhat what signified our monomeric-triferric-doxorubicine, as possibly
one of the first Pre-Chelates and our Sodium L-Thioproline, probably as one of
the first Post-Adducts. Both molecules come to the human patients with cancer
blood from the exterior. After this indication, it will be proposed a seed
concept of a new type of molecules, the “Implexes” in which the metals will be
embraced instead of being linked.
Cite this paper
Gosalvez, M. (2013) Pre-Chelates, Post-Adducts and Implexes: A perspective proposal for the future of medicinal chemistry. Advances in Biological Chemistry
, 553-555. doi: 10.4236/abc.2013.36063
 Gosalvez, M. (2013) Reversal of cancer by dual strategy? Journal of Cancer Therapy, 4, 518-520.http://dx.doi.org/10.4236/jct.2013.42064
 Gosalvez, M. (2013) Metabolic control of respiration and glycolysis of tumoral cells. Advances in Biological Chemistry, 3, 86-89.http://dx.doi.org/10.4236/abc.2013.31011
 Gosalvez, M. (2013) Cancer as a therapeutic agent? Journal of Cancer Therapy. In press.
 Gosalvez, M. (2013) Methods to be developed for some first applications of mitochondrial filamentation. Open Journal of Biophysics, 3, 51-53.http://dx.doi.org/10.4236/ojbiphy.2013.31A006
 Gosalvez, M., et al. (1976) A screening for selective anticancer agents among plant respiratory inhibitors. European Journal of Cancer, 12, 1003-1009.http://dx.doi.org/10.1016/0014-2964(76)90067-0
 Gosalvez, M., et al. (1976) Effects and specificity of anticancer agents on the respiration and energy metabolism of tumor cells. Cancer Treatment Reports, 60, 1-7.