P. C. Ng and S. Henikoff, “Accounting for Human Polymorphisms Predicted to Affect Protein Function,” Genome Research, Vol. 12, 2002, pp. 436-446. http://dx.doi.org/10.1101/gr.212802
 S. Herrgard, S. A. Cammer, B. T. Hoffman, S. Knutson, M. Gallina, J. A. Speir, J. S. Fetrow and S. M. Baxter, “Prediction of De-leterious Functional Effects of Amino Acid Mutations Using a Library of Structure-Based Function Descriptors,” Proteins-Structure Function and Genetics, Vol. 53, 2003, pp. 806-816. http://dx.doi.org/10.1002/prot.10458
 P. C. Ng and S. Henikoff, “Predicting Deleterious Amino Acid Substitutions,” Genome Research, Vol. 11, 2001, pp. 863-874. http://dx.doi.org/10.1101/gr.176601
 D. Chasman and R. M. Adams, “Predicting the Functional Consequences of Non-Synonymous Single Nucleotide Polymorphisms: Structure-Based Assessment of Amino Acid Variation,” Journal of Molecular Biology, Vol. 307, 2001, pp. 683-706. http://dx.doi.org/10.1006/jmbi.2001.4510
 Y. Bromberg and B. Rost, “SNAP: Predict Effect of Non- Synonymous Polymorphisms on Function,” Nucleic Acids Research, Vol. 35, 2007, pp. 3823-3835. http://dx.doi.org/10.1093/nar/gkm238
 E. Capriotti, R. Calabrese and R. Casadio, “Predicting the Insurgence of Human Genetic Diseases Associated to Single Point Protein Mutations with Support Vector Machines and Evolutionary Information,” Bioinformatics, Vol. 22, 2006, pp. 2729-2734. http://dx.doi.org/10.1093/bioinformatics/btl423
 J. Hu and C. Yan, “Identification of Deleterious Non- Synonymous Single Nucleotide Polymorphisms Using Sequence-Derived Information,” BMC Bioinformatics, Vol. 9, 2008. http://dx.doi.org/10.1186/1471-2105-9-297
 L. Bao and Y. Cui, “Prediction of the Phenotypic Effects of Non-Synonymous Single Nucleotide Polymorphisms Using Structural and Evolutionary Information,” Bioinformatics, Vol. 21, 2005, pp. 2185-2190. http://dx.doi.org/10.1093/bioinformatics/bti365
 V. G. Krishnan and D. R. Westhead, “A Comparative Study of Machine-Learning Methods to Predict the Effects of Single Nucleotide Polymorphisms on Protein Function,” Bioinformatics, Vol. 19, 2003, pp. 2199-2209. http://dx.doi.org/10.1093/bioinformatics/btg297
 Z.-Q. Ye, S.-Q. Zhao, G. Gao, X.-Q. Liu, R. E. Langlois, H. Lu and L. Wei, “Finding New Structural and Sequence Attributes to Predict Possible Disease Association of Single Amino Acid Lpolymorphism (SAP),” Bioinformatics, Vol. 23, 2007, pp. 1444-1450. http://dx.doi.org/10.1093/bioinformatics/btm119
 P. Yue, Z. L. Li and J. Moult, “Loss of Protein Structure Stability as a Major Causative Factor in Monogenic Disease,” Journal of Molecular Biology, Vol. 353, 2005, pp. 459-473. http://dx.doi.org/10.1016/j.jmb.2005.08.020
 T. Huang, P. Wang, Z.-Q. Ye, H. Xu, Z. He, K.-Y. Feng, L. Hu, W. Cui, K. Wang, X. Dong, L. Xie, X. Kong, Y.-D. Cai and Y. Li, “Prediction of Deleterious Non-Synonymous SNPs Based on Protein Interaction Network and Hybrid Properties,” PloS One, Vol. 5, 2010.
 S. F. Altschul, T. L. Madden, A. A. Schäffer, J. Zhang, Z. Zhang, W. Miller and D. J. Lipman, “Gapped BLAST and PSI-BLAST: A New Generation of Protein Database Search Programs,” Nucleic Acids Research, Vol. 25, 1997, pp. 3389-3402.
 J. Cheng, A. Randall and P. Baldi, “Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines,” Proteins: Structure, Function, and Bioinformatics, Vol. 62, 2006, pp. 1125-1132. http://dx.doi.org/10.1002/prot.20810
 C.-C. Chang and C.-J. Lin, “LIBSVM: A Library for Support Vector Machines,” ACM Transactions on Intelligent Systems and Technology, Vol. 2, 2011, pp. 1-27. http://dx.doi.org/10.1145/1961189.1961199
 Y. L. Yip, H. Scheib, A. V. Diemand, A. Gattiker, L. M. Famiglietti, E. Gasteiger and A. Bairoch, “The Swiss-Prot Variant Page and the ModSNP Database: A Resource for Sequence and Structure Information on Human Protein Variants,” Human Mutation, Vol. 23, 2004, pp. 464-470.