Now we extend one method into a sequence of binomial data, propose a stepwise confidence interval method for toxic-ity study, and also in our paper, two methods of constructing intervals for the risk difference are proposed. The first one is based on the well-known conditional confidence intervals for odds ratio, and the other one comes from Santner“small-sample confidence intervals for the difference of two success probabilities”, and it produces exact intervals, through employing our method.
 J. C. Hsu and R. L. Berger, “Stepwise Confidence Intervals without Multiplicity Adjustment for Dose-Response and Toxicity Studies,” Journal of the American Statistical Association, Vol. 50, 1999, pp. 468-481.
 J. Tao, N.-Z. Shi, J.-H. Guo and W. Gao, “Stepwise Procedures for the Identification of Minimum Effective Dose with Unknown Variances,” Statistics & Probability Letters, Vol. 57, 2002, pp. 121-131. http://dx.doi.org/10.1016/S0167-7152(01)00197-3
 J. Tao and N.-Z. Shi, “Stepwise Procedures under Unknown Variances for Toxicological Evaluation,” Biometrical Journal, Vol. 44, 2002, pp. 149-160. http://dx.doi.org/10.1002/1521-4036(200203)44:2<149::AID-BIMJ149>3.0.CO;2-#
 L. A. Hothorn, “Trend Tests in Epidemiology: P-Values or Confidence Intervals?” Biometrical Journal, Vol. 7, 1999, pp. 817-825. http://dx.doi.org/10.1002/(SICI)1521-4036(199911)41:7<817::AID-BIMJ817>3.0.CO;2-C
 T. J. Santner and S. Yamagami, “Invariant Small Sample Confidence Intervals for the Difference of Two Success Probabilities,” Communications in Statistics (Simulation and Computation), Vol. 22, 1993, pp. 33-59.